Polyelectrolyte Complex Micelles Composed ofc-rafAntisense Oligodeoxynucleotide−Poly(ethylene glycol) Conjugate and Poly(ethylenimine):  Effect of Systemic Administration on Tumor Growth

2005 ◽  
Vol 16 (4) ◽  
pp. 1034-1037 ◽  
Author(s):  
Ji Hoon Jeong ◽  
Sun Hwa Kim ◽  
Sung Wan Kim ◽  
Tae Gwan Park
Keyword(s):  
Ethylene Glycol ◽  
Tumor Growth ◽  
Polyelectrolyte Complex ◽  
Systemic Administration ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Complex Micelles

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2553
Author(s):  
Jeffrey M. Ting ◽  
Alexander E. Marras ◽  
Joseph D. Mitchell ◽  
Trinity R. Campagna ◽  
Matthew V. Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Raft Polymerization ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Complex Micelles

A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-block-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure–property relationships centered on poly(ethylene glycol)-block-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-block-poly(l-lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a diameter ~1.5–2× larger when PMPC-PVBTMA was used compared to PEG-PLK and PEG-PVBTMA via SAXS and DLS. In addition, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

2020 ◽  
Author(s):  
Jeffrey Ting ◽  
Alexander Marras ◽  
Joseph Mitchell ◽  
Trinity Campagna ◽  
Matthew Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Core Diameter ◽  
Poly Ethylene ◽  
Complex Micelles

<p>A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure-property relationships centered on poly(ethylene glycol)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-<i>block</i>-poly(lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a core diameter of ~40 nm when PMPC-PVBTMA was used, and smaller particles between 20-30 nm for PEG-PLK and PEG-PVBTMA via SAXS analysis. Additionally, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.</p>

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

2020 ◽  
Author(s):  
Jeffrey Ting ◽  
Alexander Marras ◽  
Joseph Mitchell ◽  
Trinity Campagna ◽  
Matthew Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Core Diameter ◽  
Poly Ethylene ◽  
Complex Micelles

<p>A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure-property relationships centered on poly(ethylene glycol)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-<i>block</i>-poly(lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a core diameter of ~40 nm when PMPC-PVBTMA was used, and smaller particles between 20-30 nm for PEG-PLK and PEG-PVBTMA via SAXS analysis. Additionally, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.</p>

scholarly journals Human Ribonuclease with a Pendant Poly(Ethylene Glycol) Inhibits Tumor Growth in Mice

2013 ◽  
Vol 6 (4) ◽  
pp. 392-397 ◽  
Author(s):  
Thomas J. Rutkoski ◽  
John A. Kink ◽  
Laura E. Strong ◽  
Ronald T. Raines
Keyword(s):  
Ethylene Glycol ◽  
Tumor Growth ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Polyion Complex Micelles Composed of All-TranS Retinoic Acid and Poly (Ethylene Glycol)-Grafted-Chitosan

2006 ◽  
Vol 95 (11) ◽  
pp. 2348-2360 ◽  
Author(s):  
Young-Il Jeong ◽  
Sang-Hyo Kim ◽  
Tae-Young Jung ◽  
In-Young Kim ◽  
Sam-Suk Kang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Poly Ethylene ◽  
Complex Micelles

Preparation and Characterization of pH Responsive Complex Micelles with Dynamic Boronate Cross-Linking

2019 ◽  
Vol 944 ◽  
pp. 557-564
Author(s):  
Jia Ming Xu ◽  
Dan Yue Wang ◽  
Han Tong ◽  
Xiao Ze Jiang ◽  
Mei Fang Zhu
Keyword(s):  
Ethylene Glycol ◽  
Phenylboronic Acid ◽  
Proton Nuclear Magnetic Resonance ◽  
Cross Linking ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Boronate Ester ◽  
H Nmr ◽  
Poly Ethylene ◽  
Complex Micelles

Two kinds of diblock copolymers containing glucose and phenylboronic acid moieties, respectively, poly (ethylene glycol)-b-poly (gluconamidoethyl methacrylate) (PEG-b-PGAMA) and poly (ethylene glycol)-b-poly (2-aminoethyl methacrylate-co-3-nitrophenyboronic acid methacrylate) (PEG-b-P(AMA-co-NPBMA)) were synthesized via atom transfer radical polymerization (ATRP) and post polymerization modification (PPM). Well-defined structure and narrow molecular weight distribution of the polymers were confirmed by proton Nuclear Magnetic Resonance (1H NMR) and Gel Permeation Chromatography (GPC). Based on the cross-linking between the diol groups of the glycopolymer and phenylboronic acid under physiological pH (7.4), complex micelles composed of PEG outer shell and boronate ester cross-linking core with a hydrodynamic diameter around 20nm were formed. Morphology, size and assembly behavior of the complex micelles were investigated by 1H NMR, transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results showed the formation/cleavage of boronate ester linkage is reversible upon the variation of solution pH, the complex micelles displayed pH sentiveties of assembling/disassembling behavior. Above pH 7.4, stable spherical micelles can be formed, whereas pH less than 5.5, the micelles dissociated into unimers. Therefore, such pH-responsive micelles based on dynamic complexation of phenyl boronate bonds are expected to be applied to pH-responsive nanodrug carriers

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