Exploration of Earth-Abundant Transition Metals (Fe, Co, and Ni) as Catalysts in Unreactive Chemical Bond Activations

2015 ◽  
Vol 48 (3) ◽  
pp. 886-896 ◽  
Author(s):  
Bo Su ◽  
Zhi-Chao Cao ◽  
Zhang-Jie Shi
Keyword(s):  
Transition Metals ◽  
Chemical Bond ◽  
Earth Abundant ◽  
Bond Activations

Catalytic C–C Bond Activations via Oxidative Addition to Transition Metals

2015 ◽  
Vol 115 (17) ◽  
pp. 9410-9464 ◽  
Author(s):  
Laetitia Souillart ◽  
Nicolai Cramer
Keyword(s):  
Transition Metals ◽  
Oxidative Addition ◽  
Bond Activations

Oxidative Transformations of Biosourced Alcohols Catalyzed by Earth-Abundant Transition Metals

ChemCatChem ◽  
2017 ◽  
Vol 9 (14) ◽  
pp. 2652-2660 ◽  
Author(s):  
Duc Hanh Nguyen ◽  
Yohann Morin ◽  
Lei Zhang ◽  
Xavier Trivelli ◽  
Frédéric Capet ◽  
...  
Keyword(s):  
Transition Metals ◽  
Earth Abundant ◽  
Oxidative Transformations

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

Functionalization of C(sp3)-H bonds adjacent to heterocycles catalyzed by earth abundant transition metals

Tetrahedron ◽  
2021 ◽  
Vol 98 ◽  
pp. 132415
Author(s):  
Aniket Gupta ◽  
Jogendra Kumar ◽  
Ajijur Rahaman ◽  
Anupam Kumar Singh ◽  
Sukalyan Bhadra
Keyword(s):  
Transition Metals ◽  
Earth Abundant

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

Recent Advances in the Sustainable Synthesis of Quinazolines Using Earth-Abundant First Row Transition Metals

2020 ◽  
Vol 24 (15) ◽  
pp. 1775-1792 ◽  
Author(s):  
Sumera Zaib ◽  
Imtiaz Khan
Keyword(s):  
Transition Metals ◽  
Organic Synthesis ◽  
Molecular Diversity ◽  
Functional Group ◽  
Transition Metal Catalysts ◽  
Mechanistic Studies ◽  
Pharmacological Activities ◽  
Modular Assembly ◽  
Diverse Range ◽  
Earth Abundant

Achieving challenging molecular diversity in contemporary chemical synthesis remains a formidable hurdle, particularly in the delivery of diversified bioactive heterocyclic pharmacophores for drug design and pharmaceutical applications. The coupling methods that combine a diverse range of readily accessible and commercially available pools of substrates under the action of earth-abundant first row transition metal catalysts have certainly matured into powerful tools, thus offering sustainable alternatives to revolutionize the organic synthesis. This minireview highlights the successful utilization of the catalytic ability of the first row transition metals (Mn, Fe, Ni, Cu) in the modular assembly of quinazoline heterocycle, ubiquitously present in numerous alkaloids, commercial medicines and is associated with a diverse range of pharmacological activities. The broad substrate scope and high functional group tolerance of the targeted methods were extensively explored, identifying the future strategic advances in the field. The investigation will also be exemplified with mechanistic studies as long as they are deemed necessary.

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