Predicting the Stereochemistry of Diphenylphosphino Benzoic Acid (DPPBA)-Based Palladium-Catalyzed Asymmetric Allylic Alkylation Reactions:  A Working Model

2006 ◽  
Vol 39 (10) ◽  
pp. 747-760 ◽  
Author(s):  
Barry M. Trost ◽  
Michelle R. Machacek ◽  
Aaron Aponick
Keyword(s):  
Benzoic Acid ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Working Model ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

2019 ◽  
Vol 23 (11) ◽  
pp. 1168-1213 ◽  
Author(s):  
Samar Noreen ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Irum Shahzadi ◽  
Ali Irfan ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Allylic Alkylation ◽  
Research Groups ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Potential ◽  
Long Time ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions. Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

Synthesis of highly rigid phosphine–oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation

2018 ◽  
Vol 16 (41) ◽  
pp. 7717-7724 ◽  
Author(s):  
Zhongxuan Qiu ◽  
Rui Sun ◽  
Dawei Teng
Keyword(s):  
Catalytic Performance ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Palladium Catalyzed ◽  
Alkylation Reactions ◽  
Stereogenic Center ◽  
Oxazoline Ligands ◽  
Excellent Catalytic Performance

Rigid phosphine–oxazoline ligands with a spirocarbon stereogenic center were developed, which exhibited excellent catalytic performance for Pd-catalyzed allylic alkylation reactions.

Origin of Enantioselectivity in Palladium-Catalyzed Asymmetric Allylic Alkylation Reactions Using Aminophosphine Ligands

2002 ◽  
Vol 21 (2) ◽  
pp. 315-325 ◽  
Author(s):  
Michael Widhalm ◽  
Ulrike Nettekoven ◽  
Hermann Kalchhauser ◽  
Kurt Mereiter ◽  
Maria José Calhorda ◽  
...  
Keyword(s):  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Polymer-SupportedC2-Symmetric Ligands for Palladium-Catalyzed Asymmetric Allylic Alkylation Reactions

2002 ◽  
Vol 114 (24) ◽  
pp. 4885-4887 ◽  
Author(s):  
Barry M. Trost ◽  
Zhengying Pan ◽  
Jorge Zambrano ◽  
Christof Kujat
Keyword(s):  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Palladium Catalyzed ◽  
Alkylation Reactions ◽  
Symmetric Ligands
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