Osteoconductive Property of a Mechanical Mixture of Octacalcium Phosphate and Amorphous Calcium Phosphate

2014 ◽  
Vol 6 (24) ◽  
pp. 22602-22611 ◽  
Author(s):  
Kazuhito Kobayashi ◽  
Takahisa Anada ◽  
Takuto Handa ◽  
Naofumi Kanda ◽  
Mariko Yoshinari ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Octacalcium Phosphate ◽  
Mechanical Mixture ◽  
Osteoconductive Property

scholarly journals Phosphoserine Functionalized Cements Preserve Metastable Phases, and Reprecipitate Octacalcium Phosphate, Hydroxyapatite, Dicalcium Phosphate, and Amorphous Calcium Phosphate, during Degradation, In Vitro

2019 ◽  
Vol 10 (4) ◽  
pp. 54 ◽  
Author(s):  
Joseph Lazraq Bystrom ◽  
Michael Pujari-Palmer
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Octacalcium Phosphate ◽  
Ionic Concentration ◽  
Strong Adhesion ◽  
Acidic Conditions ◽  
Rapid Transformation ◽  
Comparable Mass

Phosphoserine modified cements (PMC) exhibit unique properties, including strong adhesion to tissues and biomaterials. While TTCP-PMCs remodel into bone in vivo, little is known regarding the bioactivity and physiochemical changes that occur during resorption. In the present study, changes in the mechanical strength and composition were evaluated for 28 days, for three formulations of αTCP based PMCs. PMCs were significantly stronger than unmodified cement (38–49 MPa vs. 10 MPa). Inclusion of wollastonite in PMCs appeared to accelerate the conversion to hydroxyapatite, coincident with slight decrease in strength. In non-wollastonite PMCs the initial compressive strength did not change after 28 days in PBS (p > 0.99). Dissolution/degradation of PMC was evaluated in acidic (pH 2.7, pH 4.0), and supersaturated fluids (simulated body fluid (SBF)). PMCs exhibited comparable mass loss (<15%) after 14 days, regardless of pH and ionic concentration. Electron microscopy, infrared spectroscopy, and X-ray analysis revealed that significant amounts of brushite, octacalcium phosphate, and hydroxyapatite reprecipitated, following dissolution in acidic conditions (pH 2.7), while amorphous calcium phosphate formed in SBF. In conclusion, PMC surfaces remodel into metastable precursors to hydroxyapatite, in both acidic and neutral environments. By tuning the composition of PMCs, durable strength in fluids, and rapid transformation can be obtained.

Nanomechanical Properties of Titanium Coated with Octacalcium Phosphate by Immersion in a Simplified Simulated Body Fluid

2008 ◽  
Vol 396-398 ◽  
pp. 365-368
Author(s):  
E. Gemelli ◽  
Christiane Xavier Resende ◽  
Carlos M. Lepienski ◽  
Gloria Dulce de Almeida Soares
Keyword(s):  
Elastic Modulus ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Mechanical Behavior ◽  
Amorphous Calcium Phosphate ◽  
Body Fluid ◽  
Octacalcium Phosphate ◽  
Dense Structure ◽  
Nanomechanical Properties

In this study we report on the microstructure and its mechanical behavior of a Ca-P coating produced on bioactive titanium by immersion in a simplified simulated body fluid (S-SBF). The coating was probed by nanoindentation in several point times up to the formation of octacalcium phosphate (OCP). Amorphous calcium phosphate, formed after 1h of immersion in SSBF, presented the highest values of hardness (H) and elastic modulus (E). Nucleation of OCP was observed after 2-2,5h of immersion in S-SBF. From this stage on, lower values of H and E were obtained, probably due to the low dense structure of the coating.

scholarly journals Reversal of Root Caries with Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Varnish in Xerostomia

2021 ◽  
pp. 1-10
Author(s):  
Ahmed Sleibi ◽  
Anwar R. Tappuni ◽  
Aylin Baysan
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Primary Root ◽  
Severity Index ◽  
Salivary Flow ◽  
Root Caries ◽  
Carious Lesions ◽  
Group 2 ◽  
Casein Phosphopeptide ◽  
Group 1

Different formulas of topical fluoride have been used to manage root carious lesions. This clinical trial aimed to investigate the efficacy of a dental varnish containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride compared with fluoride alone in reversing/arresting root caries in xerostomic patients over 1 year. A total of 80 patients (age range 45–92 years) with primary root caries (<i>n</i> = 184 root carious lesions) and unstimulated salivary flow rate of &#x3c;0.2 mL/min were randomly allocated to receive either dental varnish containing CPP-ACP and 5% fluoride (group 1: MI varnish; GC, Japan) (<i>n</i> = 41, 83 lesions), or dental varnish with 5% fluoride alone (group 2: NUPRO White; Dentsply, USA) (<i>n</i> = 39, 101 lesions). Clinical assessments with Severity Index (SI) for root caries, DIAGNOdent measurements, and varnish application were carried out at baseline, 3, 6, and 12 months. Standard oral hygiene instructions with 1,450 ppm fluoride toothpastes were provided for both groups. After 3 months, 63.9% (<i>n</i> = 46) of root caries in group 1 became hard (SI: 0) compared with 39.3% (<i>n</i> = 35) in group 2 (<i>p</i> &#x3c; 0.01). After 6 and 12 months, the differences in SI were insignificant (group 1, <i>n</i> = 60, 83.3%) (group 2, <i>n</i> = 66, 74.2%) (<i>p</i> = 0.36), and (group 1, <i>n</i> = 60, 89.6%) (group 2, <i>n</i> = 67, 81.7%, <i>n</i> = 1 soft, 1.2%) (<i>p</i> = 0.29), respectively. In both groups, noncavitated leathery lesions were more likely to become hard when compared to the cavitated root caries. A significant decrease in plaque index, surface roughness, lesion dimension, and DIAGNOdent readings with a significant increase in lesion distance from the gingival margin was reported in both groups (<i>p</i> &#x3c; 0.05). This study has provided evidence that fluoride dental varnish either with or without calcium and phosphate has the potential to arrest/reverse root caries, especially noncavitated lesions for patients with xerostomia.

Impacts of Initial Ca/P on Amorphous Calcium Phosphate

2021 ◽  
Author(s):  
Alexandria J. Hoeher ◽  
Sebastian T. Mergelsberg ◽  
Olaf J. Borkiewicz ◽  
F. Marc Michel
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate

Casein phosphopeptide–amorphous calcium phosphate fluoride treatment enriches the symbiotic dental plaque microbiome in children

2021 ◽  
Vol 106 ◽  
pp. 103582
Author(s):  
Armelia Sari Widyarman ◽  
Nadeeka S. Udawatte ◽  
Citra Fragrantia Theodorea ◽  
Anie Apriani ◽  
Mario Richi ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Dental Plaque ◽  
Fluoride Treatment ◽  
Casein Phosphopeptide
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