Designed Fabrication of Unique Eccentric Mesoporous Silica Nanocluster-Based Core–Shell Nanostructures for pH-Responsive Drug Delivery

2013 ◽  
Vol 5 (15) ◽  
pp. 7282-7290 ◽  
Author(s):  
Lulu Chen ◽  
Lu Li ◽  
Lingyu Zhang ◽  
Shuangxi Xing ◽  
Tingting Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanostructures

Crown ether triad modified core–shell magnetic mesoporous silica nanocarrier for pH-responsive drug delivery and magnetic hyperthermia applications

2017 ◽  
Vol 41 (19) ◽  
pp. 10935-10947 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Crown Ether ◽  
Magnetic Hyperthermia ◽  
Core Shell ◽  
Ph Responsive ◽  
Magnetic Mesoporous Silica

A “host–guest” complexation-based core–shell FeNP@SiOH@CET NP system was fabricated for chemotherapy and magnetic hyperthermia applications.

scholarly journals pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

2021 ◽  
pp. 150011
Author(s):  
Eva Benova ◽  
Virginie Hornebecq ◽  
Vladimír Zelenak ◽  
Veronika Huntosova ◽  
Miroslav Almasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Co Adsorption ◽  
Ph Responsive

Decoration of upconversion nanoparticles@mSiO2 core–shell nanostructures with CdS nanocrystals for excellent infrared light triggered photocatalysis

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54241-54248 ◽  
Author(s):  
Yao-Wu Li ◽  
Liang Dong ◽  
Chen-Xi Huang ◽  
Yan-Chuan Guo ◽  
Xian-Zhu Yang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Photocatalytic Degradation ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Core Shell ◽  
Cds Nanocrystals ◽  
Shell Nanostructures ◽  
Cds Nanostructures

Upconversion nanoparticles@mesoporous silica (mSiO2)/CdS nanostructures have been designed and fabricated for infrared light triggered photocatalytic degradation towards RhB dye.

scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

A pH-responsive amphiphilic chitosan–pyranine core–shell nanoparticle for controlled drug delivery, imaging and intracellular pH measurement

2014 ◽  
Vol 2 (38) ◽  
pp. 6580-6589 ◽  
Author(s):  
Hao-Syun Chou ◽  
Meng-Hsuan Hsiao ◽  
Wei-Yang Hung ◽  
Tin-Yo Yen ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Ph ◽  
Controlled Drug Delivery ◽  
Ph Measurement ◽  
Core Shell ◽  
Ph Responsive ◽  
Cellular Resolution ◽  
New Type

A new type of CHC–PY core–shell nanoparticle provides multiple functionality, where a synergistic performance of nanotherapeutics, imaging and even diagnosis at a cellular resolution can be achieved simultaneously.

scholarly journals pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017 ◽  
Vol 4 (4) ◽  
pp. 3 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
Miguel Manzano ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Carbon Nanoparticles ◽  
Ph Responsive
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