Facile Incorporation of Aggregation-Induced Emission Materials into Mesoporous Silica Nanoparticles for Intracellular Imaging and Cancer Therapy

2013 ◽  
Vol 5 (6) ◽  
pp. 1943-1947 ◽  
Author(s):  
Xiaoyong Zhang ◽  
Xiqi Zhang ◽  
Shiqi Wang ◽  
Meiying Liu ◽  
Yun Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Intracellular Imaging ◽  
Aggregation Induced Emission

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy

2020 ◽  
Vol 12 (4) ◽  
pp. 4308-4322 ◽  
Author(s):  
Yazhe Wang ◽  
Ying Xie ◽  
Kameron V. Kilchrist ◽  
Jing Li ◽  
Craig L. Duvall ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Combination Cancer Therapy

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Combination of aggregation-induced emission and clusterization-triggered emission in mesoporous silica nanoparticles for the construction of an efficient artificial light-harvesting system

2020 ◽  
Vol 8 (41) ◽  
pp. 14587-14594
Author(s):  
Saisai Yan ◽  
Zhinong Gao ◽  
Hongyan Yan ◽  
Fei Niu ◽  
Zhengqin Zhang
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Light Harvesting ◽  
Mesoporous Silica Nanoparticles ◽  
Aqueous Environment ◽  
Artificial Light ◽  
Aggregation Induced Emission ◽  
Highly Efficient ◽  
System P

A highly efficient ALHS was constructed based on the non-covalent assembly of fluorescent MSNs and RB in an aqueous environment.

Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review

2020 ◽  
Vol 14 (4) ◽  
pp. 373-386
Author(s):  
Yimin Zhou ◽  
Qingni Xu ◽  
Chaohua Li ◽  
Yuqi Chen ◽  
Yueli Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hollow Mesoporous Silica
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