scholarly journals Auranofin-Based Analogues Are Effective Against Clear Cell Renal Carcinoma In Vivo and Display No Significant Systemic Toxicity

2020 ◽  
Vol 3 (4) ◽  
pp. 644-654
Author(s):  
Benelita T. Elie ◽  
Karen Hubbard ◽  
Buddhadev Layek ◽  
Won Seok Yang ◽  
Swayam Prabha ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Systemic Toxicity ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

scholarly journals The In vitro and In vivo Effects of Re-Expressing Methylated von Hippel-Lindau Tumor Suppressor Gene in Clear Cell Renal Carcinoma with 5-Aza-2′-deoxycytidine

2004 ◽  
Vol 10 (20) ◽  
pp. 7011-7021 ◽  
Author(s):  
Wade G. Alleman ◽  
Ray L. Tabios ◽  
Gadisetti V. R. Chandramouli ◽  
Olga N. Aprelikova ◽  
Carlos Torres-Cabala ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Suppressor Gene ◽  
Clear Cell Renal Carcinoma ◽  
Von Hippel Lindau ◽  
Cell Renal Carcinoma ◽  
In Vivo Effects

Future Perspectives for Diagnostic Imaging in Urology: From Anatomic and Functional to Molecular Imaging

2013 ◽  
Vol 80 (1) ◽  
pp. 29-41 ◽  
Author(s):  
Giuseppe Macis ◽  
Silvia Di Giovanni ◽  
Davide Di Franco ◽  
Lorenzo Bonomo
Keyword(s):  
Molecular Imaging ◽  
Diagnostic Imaging ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Molecular Probe ◽  
Molecular Processes ◽  
Clear Cell Renal Carcinoma ◽  
The Future ◽  
Cell Renal Carcinoma

The future approach of diagnostic imaging in urology follows the technological progress, which made the visualization of in vivo molecular processes possible. From anatomo-morphological diagnostic imaging and through functional imaging molecular radiology is reached. Based on molecular probes, imaging is aimed at assessing the in vivo molecular processes, their physiology and function at cellular level. The future imaging will investigate the complex tumor functioning as metabolism, aerobic glycolysis in particular, angiogenesis, cell proliferation, metastatic potential, hypoxia, apoptosis and receptors expressed by neoplastic cells. Methods for performing molecular radiology are CT, MRI, PET-CT, PET-MRI, SPECT and optical imaging. Molecular ultrasound combines technological advancement with targeted contrast media based on microbubbles, this allowing the selective registration of microbubble signal while that of stationary tissues is suppressed. An experimental study was carried out where the ultrasound molecular probe BR55 strictly bound to prostate tumor results in strong enhancement in the early phase after contrast, this contrast being maintained in the late phase. This late enhancement is markedly significant for the detection of prostatic cancer foci and to guide the biopsy sampling. The 124I-cG250 molecular antibody which is strictly linked to cellular carbonic anhydrase IX of clear cell renal carcinoma, allows the acquisition of diagnostic PET images of clear cell renal carcinoma without biopsy. This WG-250 (RENCAREX) antibody was used as a therapy in metastatic clear cell renal carcinoma. Future advancements and applications will result in early cancer diagnosis, personalized therapy that will be specific according to the molecular features of cancer and leading to the development of catheter–based multichannel molecular imaging devices for cystoscopy-based molecular imaging diagnosis and intervention.

1651: Molecular Prognostic Modeling Using Protein Expression Profile in Clear Cell Renal Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 436-436 ◽  
Author(s):  
Hyung L. Kim ◽  
David B. Seligson ◽  
Nicolette Janzen ◽  
Matthew H. Bui ◽  
Robert A. Figlin ◽  
...  
Keyword(s):  
Protein Expression ◽  
Expression Profile ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Protein Expression Profile ◽  
Cell Renal Carcinoma ◽  
Prognostic Modeling

scholarly journals The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

Oncogene ◽  
2007 ◽  
Vol 26 (45) ◽  
pp. 6499-6508 ◽  
Author(s):  
J S P Yuen ◽  
M E Cockman ◽  
M Sullivan ◽  
A Protheroe ◽  
G D H Turner ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

scholarly journals The Influence of the Extremely Low Frequency Electromagnetic Field on Clear Cell Renal Carcinoma

2021 ◽  
Vol 22 (3) ◽  
pp. 1342
Author(s):  
Aleksandra Cios ◽  
Martyna Ciepielak ◽  
Wanda Stankiewicz ◽  
Łukasz Szymański
Keyword(s):  
Electromagnetic Field ◽  
Cancer Cells ◽  
Cell Lines ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Low Frequency ◽  
Inhibitory Effect ◽  
Hek293 Cells ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

The development of new technologies and industry is conducive to the increase in the number and variety of electromagnetic field (EMF) sources in our environment. The main sources of EMF are high-voltage lines, household appliances, audio/video devices, mobile phones, radio stations, and radar devices. In the growing use of electronic devices, scientists are increasingly interested in the effects of EMF on human health. Even though many studies on the effects of EMF have already been carried out, none of them has shown a significant effect on mammals, including humans. Moreover, it is not entirely clear how EMF influences cell behavior. The International Agency for Research on Cancer on 31 May 2011, classified PEM as a possible carcinogenic factor. This study aimed to investigate the effect of the electromagnetic field on morphological and functional changes in clear cell renal carcinoma. The research was carried out on in vitro cultures of four cell lines: HEK293, 786-O 769-P, and Caki1. The results of the research showed that the EMF of low frequency had a slight effect on the viability of cells. EMF, which induced cell arrest in the G1 phase, increased the number of early apoptotic cells and decreased the number of viable cells in the 786-O line. EMF did not affect the proliferation and viability of HEK293 cells. Extreme low-frequency EMF (ELF-EMF) also showed an inhibitory effect on the migration and metastatic properties of clear cell kidney cancer cells. Moreover, shortly after the end of ELF-EMF exposure, significant increases in ROS levels were observed in all tested cell lines. As part of the work, it was shown that low-frequency EMF shows an inhibitory effect on the proliferation of primary cancer cells, diminishing their migratory, invasive, and metastatic abilities. It also increases the apoptosis of cancer cells and the amount of reactive oxygen species. Based on the results of our research, we want to point up that the effect of ELF-EMF depends on a specific metabolic state or at a specific stage in the cell cycle of the cells under study.

A combined postoperative nomogram for survival prediction in clear cell renal carcinoma

2021 ◽  
Author(s):  
Ying Ming ◽  
Xinyi Chen ◽  
Jingxu Xu ◽  
Haiyu Zhan ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Survival Prediction ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

scholarly journals TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ

2019 ◽  
Vol Volume 12 ◽  
pp. 9861-9871
Author(s):  
Yong Yang ◽  
Jinhai Fan ◽  
Shenglu Han ◽  
Enyuan Li
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

scholarly journals Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma

2010 ◽  
Vol 78 (6) ◽  
pp. 1072-1078 ◽  
Author(s):  
Hye-Sik Kong ◽  
Sunmin Lee ◽  
Kristin Beebe ◽  
Bradley Scroggins ◽  
Gopal Gupta ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Hypoxia Inducible Factor ◽  
Clear Cell Renal Carcinoma ◽  
Von Hippel Lindau ◽  
Cell Renal Carcinoma
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