scholarly journals Novel Genetic Variant of a Class B G Protein-Coupled Receptor Reveals a Role for Adrenomedullin in Human Fertility

2018 ◽  
Vol 1 (2) ◽  
pp. 138-139
Author(s):  
Debbie L. Hay
Keyword(s):  
G Protein ◽  
Genetic Variant ◽  
G Protein Coupled Receptor ◽  
Human Fertility ◽  
Class B ◽  
G Protein Coupled

Mechanochemical Activation of Class-B G-Protein-Coupled Receptor upon Peptide–Ligand Binding

Nano Letters ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 5575-5582 ◽  
Author(s):  
Cristina Lo Giudice ◽  
Haonan Zhang ◽  
Beili Wu ◽  
David Alsteens
Keyword(s):  
Ligand Binding ◽  
G Protein ◽  
Mechanochemical Activation ◽  
Peptide Ligand ◽  
G Protein Coupled Receptor ◽  
Class B ◽  
G Protein Coupled

Receptor Activity Modifying Proteins Have Limited Effects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-Like Receptor Stalk

Biochemistry ◽  
2018 ◽  
Vol 57 (8) ◽  
pp. 1410-1422 ◽  
Author(s):  
Michael L. Garelja ◽  
Christina A. Walker ◽  
Andrew Siow ◽  
Sung H. Yang ◽  
Paul W.R. Harris ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Activity ◽  
Calcitonin Receptor ◽  
G Protein Coupled Receptor ◽  
Class B ◽  
Receptor Activity Modifying Proteins ◽  
G Protein Coupled

scholarly journals Conserved 2nd Residue of Helix 8 of GPCR May Confer the Subclass-Characteristic and Distinct Roles through a Rapid Initial Interaction with Specific G Proteins

2019 ◽  
Vol 20 (7) ◽  
pp. 1752 ◽  
Author(s):  
Sato
Keyword(s):  
Amino Acids ◽  
G Protein ◽  
G Proteins ◽  
Specific Interactions ◽  
G Protein Coupled Receptor ◽  
Conserved Residues ◽  
Trace Amine ◽  
Class B ◽  
Initial Interaction ◽  
G Protein Coupled

To obtain a systematic view of the helix-8-second residue responsible for G protein-coupled receptor (GPCR)–G protein initial specific interactions, 786 human GPCRs were subclassified based on the pairs of agonist groups and target G proteins and compared with their conserved second residue of helix 8. Of 314 non-olfactory and deorphanized GPCRs, 273 (87%) conserved single amino acids in the subclasses, while 93 (58%) of the 160 subclasses possessed only a single GPCR member. Class B, C, Frizzled, and trace amine-associated GPCRs demonstrated 100% conservation, whereas class Ⅰ and Ⅱ olfactory and vomeronasal 1 receptors demonstrated much lower rates of conservation (20–47%). These conserved residues are characteristic of GPCR classes and G protein subtypes and confer their functionally-distinct roles.

scholarly journals Allosteric Optical Control of a Class B G-Protein-Coupled Receptor

2016 ◽  
Vol 55 (19) ◽  
pp. 5865-5868 ◽  
Author(s):  
Johannes Broichhagen ◽  
Natalie R. Johnston ◽  
Yorrick von Ohlen ◽  
Helena Meyer-Berg ◽  
Ben J. Jones ◽  
...  
Keyword(s):  
G Protein ◽  
Optical Control ◽  
G Protein Coupled Receptor ◽  
Class B ◽  
G Protein Coupled
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