scholarly journals Development of a High-Throughput Homogeneous AlphaLISA Drug Screening Assay for the Detection of SARS-CoV-2 Nucleocapsid

2020 ◽  
Vol 3 (6) ◽  
pp. 1233-1241
Author(s):  
Kirill Gorshkov ◽  
Catherine Z. Chen ◽  
Miao Xu ◽  
Juan Carlos de la Torre ◽  
Luis Martinez-Sobrido ◽  
...  
Keyword(s):  
High Throughput ◽  
Drug Screening ◽  
Screening Assay ◽  
Drug Screening Assay

scholarly journals Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia

Cancer ◽  
2013 ◽  
Vol 120 (4) ◽  
pp. 589-602 ◽  
Author(s):  
Katja Karjalainen ◽  
Renata Pasqualini ◽  
Jorge E. Cortes ◽  
Steven M. Kornblau ◽  
Benjamin Lichtiger ◽  
...  
Keyword(s):  
High Throughput ◽  
Drug Screening ◽  
Human Leukemia ◽  
Design Development ◽  
Screening Assay ◽  
High Throughput Drug Screening ◽  
Drug Screening Assay ◽  
Development And Validation

Development of a High Throughput Drug Screening Assay for the Detection of Changes in Tau Levels - Proof of Concept with HSP90 inhibitors

2005 ◽  
Vol 2 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Chad Dickey ◽  
Jason Eriksen ◽  
Adeela Kamal ◽  
Francis Burrows ◽  
Srinivas Kasibhatla ◽  
...  
Keyword(s):  
High Throughput ◽  
Drug Screening ◽  
Proof Of Concept ◽  
Hsp90 Inhibitors ◽  
Screening Assay ◽  
High Throughput Drug Screening ◽  
Drug Screening Assay

scholarly journals Investigation of the Antimicrobial Activity of Soy Peptides by Developing a High Throughput Drug Screening Assay

2016 ◽  
Author(s):  
Rekha Dhayakaran ◽  
Suresh Neethirajan ◽  
Xuan Weng
Keyword(s):  
Antimicrobial Activity ◽  
Raman Spectroscopy ◽  
Optical Microscopy ◽  
High Throughput ◽  
Drug Screening ◽  
Rapid Screening ◽  
Screening Assay ◽  
High Throughput Drug Screening ◽  
Soy Peptides ◽  
Drug Screening Assay

Background: Antimicrobial resistance is a great concern in the medical community, as well as food industry. Soy peptides were tested against bacterial biofilms for their antimicrobial activity. A high throughput drug screening assay was developed using microfluidic technology, RAMAN spectroscopy, and optical microscopy for rapid screening of antimicrobials and rapid identification of pathogens. Methods: Synthesized PGTAVFK and IKAFKEATKVDKVVVLWTA soy peptides were tested against Pseudomonas aeruginosa and Listeria monocytogenes using a microdilution assay. Microfluidic technology in combination with Surface Enhanced RAMAN Spectroscopy (SERS) and optical microscopy was used for rapid screening of soy peptides, pathogen identification, and to visualize the impact of selected peptides. Results: The PGTAVFK peptide did not significantly affect P. aeruginosa, although it had an inhibitory effect on L. monocytogenes above a concentration of 625 uM. IKAFKEATKVDKVVVLWTA was effective against both P. aeruginosa and L. monocytogenes above a concentration of 37.2 uM. High throughput drug screening assays were able to reduce the screening and bacterial detection time to 4 h. SERS spectra was used to distinguish the two bacterial species.

scholarly journals Microengineered peripheral nerve-on-a-chip for preclinical physiological testing

Lab on a Chip ◽  
2015 ◽  
Vol 15 (10) ◽  
pp. 2221-2232 ◽  
Author(s):  
Renee M. Huval ◽  
Oliver H. Miller ◽  
J. Lowry Curley ◽  
Yuwei Fan ◽  
Benjamin J. Hall ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Drug Screening ◽  
Late Stage ◽  
Nerve Tissue ◽  
Physiological Measures ◽  
Screening Assay ◽  
Lead Compounds ◽  
Drug Screening Assay

A microscale, organotypicin vitromodel of sensory peripheral nerve tissue may be assessed with clinically-relevant morphological and physiological measures for use as a drug screening assay for selecting promising lead compounds with higher chances of late-stage success.

scholarly journals A drug screening assay on cancer cells chronically adapted to acidosis

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Paola Pellegrini ◽  
Jason T. Serviss ◽  
Thomas Lundbäck ◽  
Nicolo Bancaro ◽  
Magdalena Mazurkiewicz ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Drug Screening ◽  
Screening Assay ◽  
Drug Screening Assay
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