scholarly journals Physiologically Based Population Pharmacokinetic Modeling Approach for Ciprofloxacin in Bone of Patients Undergoing Orthopedic Surgery

2020 ◽  
Vol 3 (3) ◽  
pp. 444-454 ◽  
Author(s):  
Cornelia B. Landersdorfer ◽  
Martina Kinzig ◽  
Rainer Höhl ◽  
Peter Kempf ◽  
Roger L. Nation ◽  
...  
Keyword(s):  
Orthopedic Surgery ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling ◽  
Modeling Approach ◽  
Physiologically Based

Individuals, Subgroups or Cohorts? A Population Pharmacokinetic Modeling Approach to Optimize Dosing of Hizentra®

2013 ◽  
Vol 131 (2) ◽  
pp. AB227 ◽  
Author(s):  
Martin Bexon ◽  
Jonathan M. Edelman ◽  
Mikhail Rojavin ◽  
Jutta Neufang-Hueber ◽  
Jagdev S. Sidhu ◽  
...  
Keyword(s):  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling ◽  
Modeling Approach

scholarly journals Pharmacokinetic Comparison between Methotrexate-Loaded Nanoparticles and Nanoemulsions as Hard- and Soft-Type Nanoformulations: A Population Pharmacokinetic Modeling Approach

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1050
Author(s):  
Seung-Hyun Jeong ◽  
Ji-Hun Jang ◽  
Yong-Bok Lee
Keyword(s):  
Olive Oil ◽  
Glycolic Acid ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Drug Formulations ◽  
Population Pharmacokinetic Modeling ◽  
Modeling Approach

The purpose of this study was to identify and explore the differences in pharmacokinetics between different nanoformulations. This was done by comparing the pharmacokinetics of methotrexate-loaded nanoparticles [poly(lactic-co-glycolic acid); size of 163.70 ± 10.25 nm] and nanoemulsions (olive oil and Labrasol; size of 173.77 ± 5.76 nm), which represent hard- and soft-type nanoformulations, respectively. In addition, the population pharmacokinetic modeling approach as a useful tool for the comparison of pharmacokinetics between nanoformulations was newly proposed through this study. Significant pharmacokinetic differences were identified between nanoformulations through the new population pharmacokinetic modeling approach. As a result, the formulation type was explored as a significant covariate. The clearance and bioavailability of methotrexate-loaded nanoemulsions tended to decrease by 99% and increase by 19%, respectively, compared to those of the nanoparticles. The exploration of significant pharmacokinetic differences between drug formulations and their correlations presented in this study provide new perspectives on the development of nanoformulations.

A Population Pharmacokinetic Modeling Approach to Determine the Efficacy of Intravenous Amikacin in Children with Cystic Fibrosis

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jean-Baptiste Woillard ◽  
Stéphane Bouchet ◽  
Michael Fayon ◽  
Pierre Marquet ◽  
Caroline Monchaud ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling ◽  
Modeling Approach
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