scholarly journals Bioactive Compounds of Mediterranean Cooked Tomato Sauce (Sofrito) Modulate Intestinal Epithelial Cancer Cell Growth Through Oxidative Stress/Arachidonic Acid Cascade Regulation

ACS Omega ◽  
2020 ◽  
Vol 5 (28) ◽  
pp. 17071-17077
Author(s):  
Carolina E. Storniolo ◽  
Ignasi Sacanella ◽  
Rosa M. Lamuela-Raventos ◽  
Juan J. Moreno
Keyword(s):  
Oxidative Stress ◽  
Arachidonic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bioactive Compounds ◽  
Intestinal Epithelial ◽  
Arachidonic Acid Cascade ◽  
Epithelial Cancer ◽  
Cancer Cell Growth ◽  
Tomato Sauce

scholarly journals Retraction Note: Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Naoki Fujitani ◽  
Akihiro Yoneda ◽  
Motoko Takahashi ◽  
Akira Takasawa ◽  
Tomoyuki Aoyama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Growth ◽  
Cancer Cell ◽  
Glutathione S Transferase ◽  
Mitochondria Dysfunction ◽  
Cancer Cell Growth ◽  
Link Type

Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-77205-9

Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf.

2007 ◽  
Vol 15 (14) ◽  
pp. 4923-4932 ◽  
Author(s):  
G.K. Jayaprakasha ◽  
K.K. Mandadi ◽  
Shibu M. Poulose ◽  
Y. Jadegoud ◽  
G.A. Nagana Gowda ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antioxidant Activity ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bioactive Compounds ◽  
Colon Cancer Cell ◽  
Poncirus Trifoliata ◽  
Cancer Cell Growth

scholarly journals Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

2020 ◽  
Vol 21 (13) ◽  
pp. 4652 ◽  
Author(s):  
Chia-Chien Hsieh ◽  
Huai-Hsuan Chiu ◽  
Chih-Hsuan Wang ◽  
Ching-Hua Kuo
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Fatty Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
Breast Cancer Cell Growth ◽  
And Migration

Breast cancer is the most common cancer among women. Adiposity generally accompanies immune cell infiltration and cytokine secretion, which is ideal for tumor development. Aspirin is a chemopreventive agent against several types of cancer. The aim of this study was to investigate whether aspirin inhibits the growth of 4T1 breast cancer cells by inhibiting the inflammatory response and regulating the metabolomic profile of 3T3-L1 adipocytes. 3T3-L1 adipocyte-conditioned medium (Ad-CM) was used to mimic the obese adipose tissue microenvironment in 4T1 cells. The results revealed that aspirin inhibited macrophage chemoattractant protein (MCP-1), interleukin (IL-6), IL-1β, and plasminogen activator inhibitor (PAI-1) production in 3T3-L1 adipocytes stimulated by tumor necrosis factor-alpha (TNF-α) and lipopolysaccharide (LPS). In the obesity-associated model, Ad-CM significantly promoted 4T1 cell growth and migration, which were attenuated after aspirin treatment. The results of metabolic analyses using Ad-CM showed that amino acid metabolites and oxidative stress were increased in mature 3T3-L1 adipocytes compared to those in fibroblasts. Aspirin treatment modified metabolites involved in suppressing lipogenesis, oxidative stress, and neoplastic formation. In the relative fatty acid quantitation analysis of Ad-CM, aspirin diminished fatty acid contents of C16:1, C18:1, C18:2, C20:4, and C24:1. This study is the first to show that aspirin modifies the metabolomics and fatty acid composition of 3T3-L1 adipocytes and inhibits obesity-associated inflammation that contributes to obesity-related breast cancer cell growth and migration.

scholarly journals Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness

Nutrients ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 439 ◽  
Author(s):  
Jisoo Lee ◽  
Yoo-Sun Kim ◽  
JaeHwan Lee ◽  
Seung Heo ◽  
Kook Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bioactive Compounds ◽  
Colon Cancer Cell ◽  
Cancer Cell Growth ◽  
Cancer Stemness ◽  
Phenolic Extract
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