scholarly journals Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance

ACS Omega ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 498-506 ◽  
Author(s):  
Manojkumar Varada ◽  
Manisha Aher ◽  
Namrata Erande ◽  
Vaijayanti A. Kumar ◽  
Moneesha Fernandes
Keyword(s):  
Thermal Stability ◽  
Nuclease Resistance

scholarly journals NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance

2019 ◽  
Vol 47 (9) ◽  
pp. 4872-4882 ◽  
Author(s):  
Andrei Istrate ◽  
Silke Johannsen ◽  
Alena Istrate ◽  
Roland K O Sigel ◽  
Christian J Leumann
Keyword(s):  
Thermal Stability ◽  
Solution Structure ◽  
Nmr Solution Structure ◽  
Nuclease Resistance ◽  
Insight Into

Synthesis of Oligodeoxynucleotides Containing 4′-C-Aminoalkyl-thymidines and Their Thermal Stability and Nuclease-Resistance Properties

1999 ◽  
Vol 18 (6-7) ◽  
pp. 1401-1402 ◽  
Author(s):  
Yoshihito Ueno ◽  
Makiko Kanazaki ◽  
Satoshi Shuto ◽  
Akira Matsuda
Keyword(s):  
Thermal Stability ◽  
Nuclease Resistance

scholarly journals Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

2018 ◽  
Vol 46 (16) ◽  
pp. 8090-8104 ◽  
Author(s):  
Joel M Harp ◽  
Dale C Guenther ◽  
Anna Bisbe ◽  
Lydia Perkins ◽  
Shigeo Matsuda ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Structural Basis ◽  
Nuclease Resistance ◽  
Rnai Activity

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance

2014 ◽  
Vol 12 (44) ◽  
pp. 8840-8843 ◽  
Author(s):  
Veronica Esposito ◽  
Maria Scuotto ◽  
Antonella Capuozzo ◽  
Rita Santamaria ◽  
Michela Varra ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Simple Modification ◽  
Nuclease Resistance ◽  
The Stability

Introduction of inversion of polarity sites at the 5′- and/or 3′-end in the thrombin binding aptamer is a simple modification able to improve, at the same time, thermal stability, affinity to thrombin and nuclease resistance.

scholarly journals 4′-C-Aminoethoxy modification enhanced nuclease resistance of RNAs and improved thermal stability of RNA duplexes

2021 ◽  
pp. 100231
Author(s):  
Ryo Tsukimura ◽  
Ryohei Kajino ◽  
Yujun Zhou ◽  
Akash Chandela ◽  
Yoshihito Ueno
Keyword(s):  
Thermal Stability ◽  
Rna Duplexes ◽  
Nuclease Resistance ◽  
Thermal Stability Of
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