scholarly journals Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity

ACS Omega ◽  
2019 ◽  
Vol 4 (13) ◽  
pp. 15694-15701 ◽  
Author(s):  
Hyunhee Lee ◽  
Sung In Lim ◽  
Sung-Heui Shin ◽  
Yong Lim ◽  
Jae Woong Koh ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antimicrobial Peptides ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides

MedChemComm ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 982-987 ◽  
Author(s):  
Ezequiel Silva Nigenda ◽  
Tobias M. Postma ◽  
Mohammed Hezwani ◽  
Alin Pirvan ◽  
Susan Gannon ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Cell Penetrating Peptides ◽  
Amphiphilic Peptides ◽  
Cell Penetrating

A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides.

scholarly journals Membrane Active Peptides and Their Biophysical Characterization

Biomolecules ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 77 ◽  
Author(s):  
Fatma Gizem Avci ◽  
Berna Sariyar Akbulut ◽  
Elif Ozkirimli
Keyword(s):  
Antimicrobial Peptides ◽  
Single Molecule ◽  
Imaging Techniques ◽  
Membrane Integrity ◽  
Cell Penetrating Peptides ◽  
Single Molecule Level ◽  
Active Peptides ◽  
Cell Penetrating ◽  
Biophysical Techniques ◽  
Membrane Active Peptides

In the last 20 years, an increasing number of studies have been reported on membrane active peptides. These peptides exert their biological activity by interacting with the cell membrane, either to disrupt it and lead to cell lysis or to translocate through it to deliver cargos into the cell and reach their target. Membrane active peptides are attractive alternatives to currently used pharmaceuticals and the number of antimicrobial peptides (AMPs) and peptides designed for drug and gene delivery in the drug pipeline is increasing. Here, we focus on two most prominent classes of membrane active peptides; AMPs and cell-penetrating peptides (CPPs). Antimicrobial peptides are a group of membrane active peptides that disrupt the membrane integrity or inhibit the cellular functions of bacteria, virus, and fungi. Cell penetrating peptides are another group of membrane active peptides that mainly function as cargo-carriers even though they may also show antimicrobial activity. Biophysical techniques shed light on peptide–membrane interactions at higher resolution due to the advances in optics, image processing, and computational resources. Structural investigation of membrane active peptides in the presence of the membrane provides important clues on the effect of the membrane environment on peptide conformations. Live imaging techniques allow examination of peptide action at a single cell or single molecule level. In addition to these experimental biophysical techniques, molecular dynamics simulations provide clues on the peptide–lipid interactions and dynamics of the cell entry process at atomic detail. In this review, we summarize the recent advances in experimental and computational investigation of membrane active peptides with particular emphasis on two amphipathic membrane active peptides, the AMP melittin and the CPP pVEC.

scholarly journals Peptides and Dendrimers: How to Combat Viral and Bacterial Infections

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 101
Author(s):  
Annarita Falanga ◽  
Valentina Del Genio ◽  
Stefania Galdiero
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
Cell Penetrating Peptides ◽  
High Potential ◽  
Permanent Damage ◽  
Antiviral Peptides ◽  
Cell Penetrating ◽  
Novel Approaches

The alarming growth of antimicrobial resistance and recent viral pandemic events have enhanced the need for novel approaches through innovative agents that are mainly able to attach to the external layers of bacteria and viruses, causing permanent damage. Antimicrobial molecules are potent broad-spectrum agents with a high potential as novel therapeutics. In this context, antimicrobial peptides, cell penetrating peptides, and antiviral peptides play a major role, and have been suggested as promising solutions. Furthermore, dendrimers are to be considered as suitable macromolecules for the development of advanced nanosystems that are able to complement the typical properties of dendrimers with those of peptides. This review focuses on the description of nanoplatforms constructed with peptides and dendrimers, and their applications.

scholarly journals The role of membrane tension in the action of antimicrobial peptides and cell-penetrating peptides in biomembranes

2019 ◽  
Vol 11 (3) ◽  
pp. 431-448 ◽  
Author(s):  
Moynul Hasan ◽  
Md. Mizanur Rahman Moghal ◽  
Samiron Kumar Saha ◽  
Masahito Yamazaki
Keyword(s):  
Antimicrobial Peptides ◽  
Cell Penetrating Peptides ◽  
Membrane Tension ◽  
Cell Penetrating

scholarly journals Antimicrobial Peptides and Cell-Penetrating Peptides for Treating Intracellular Bacterial Infections

2021 ◽  
Vol 10 ◽  
Author(s):  
Danieli F. Buccini ◽  
Marlon H. Cardoso ◽  
Octavio L. Franco
Keyword(s):  
Antimicrobial Peptides ◽  
Bacterial Infections ◽  
Antibacterial Activities ◽  
Cell Penetrating Peptides ◽  
Host Cells ◽  
Host Cell Membrane ◽  
Infection Treatment ◽  
Cell Penetrating ◽  
High Doses ◽  
Higher Doses

Bacterial infections caused by intracellular pathogens are difficult to control. Conventional antibiotic therapies are often ineffective, as high doses are needed to increase the number of antibiotics that will cross the host cell membrane to act on the intracellular bacterium. Moreover, higher doses of antibiotics may lead to elevated severe toxic effects against host cells. In this context, antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs) have shown great potential to treat such infections by acting directly on the intracellular pathogenic bacterium or performing the delivery of cargos with antibacterial activities. Therefore, in this mini-review, we cover the main AMPs and CPPs described to date, aiming at intracellular bacterial infection treatment. Moreover, we discuss some of the proposed mechanisms of action for these peptide classes and their conjugation with other antimicrobials.

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