scholarly journals Superabsorbent and Fully Biobased Protein Foams with a Natural Cross-Linker and Cellulose Nanofibers

ACS Omega ◽  
2019 ◽  
Vol 4 (19) ◽  
pp. 18257-18267 ◽  
Author(s):  
Antonio J. Capezza ◽  
Qiong Wu ◽  
William R. Newson ◽  
Richard T. Olsson ◽  
Eliane Espuche ◽  
...  
Keyword(s):  
Cellulose Nanofibers ◽  
Cross Linker ◽  
Natural Cross

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Immobilization of laccase via cross-linked enzyme aggregates prepared using genipin as a natural cross-linker

2021 ◽  
Vol 169 ◽  
pp. 541-550
Author(s):  
Jiyeon Hong ◽  
Dahun Jung ◽  
Saerom Park ◽  
Yujin Oh ◽  
Kyeong Keun Oh ◽  
...  
Keyword(s):  
Cross Linker ◽  
Natural Cross

Modification of collagen with a natural cross-linker, procyanidin

2011 ◽  
Vol 48 (2) ◽  
pp. 354-359 ◽  
Author(s):  
Lirong He ◽  
Changdao Mu ◽  
Jiabo Shi ◽  
Qian Zhang ◽  
Bi Shi ◽  
...  
Keyword(s):  
Cross Linker ◽  
Natural Cross

Natural cross-linker-stabilized acellular porcine corneal stroma for lamellar keratoplasty

2020 ◽  
Vol 114 ◽  
pp. 270-284
Author(s):  
Hua Li ◽  
Long Zhao ◽  
Fuyan Wang ◽  
Hongwei Wang ◽  
Muchen Dong ◽  
...  
Keyword(s):  
Corneal Stroma ◽  
Lamellar Keratoplasty ◽  
Cross Linker ◽  
Natural Cross

scholarly journals Crocetin as New Cross-Linker for Bioactive Sericin Nanoparticles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 680
Author(s):  
Sara Perteghella ◽  
Giovanna Rassu ◽  
Elisabetta Gavini ◽  
Antonella Obinu ◽  
Elia Bari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Fibroblasts ◽  
Brain Targeting ◽  
Brain Delivery ◽  
Ros Scavenging ◽  
Freeze Dried ◽  
Cross Linker ◽  
The Brain ◽  
Natural Cross

The nose-to-brain delivery route is used to bypass the blood–brain barrier and deliver drugs directly into the brain. Over the years, significant signs of progress have been made in developing nano-drug delivery systems to address the very low drug transfer levels seen with conventional formulations (e.g., nasal solutions). In this paper, sericin nanoparticles were prepared using crocetin as a new bioactive natural cross-linker (NPc) and compared to sericin nanoparticles prepared with glutaraldehyde (NPg). The mean diameter of NPc and NPg was about 248 and 225 nm, respectively, and suitable for nose-to-brain delivery. The morphological investigation revealed that NPc are spherical-like particles with a smooth surface, whereas NPg seem small and rough. NPc remained stable at 4 °C for 28 days, and when freeze-dried with 0.1% w/v of trehalose, the aggregation was prevented. The use of crocetin as a natural cross-linker significantly improved the in vitro ROS-scavenging ability of NPc with respect to NPg. Both formulations were cytocompatible at all the concentrations tested on human fibroblasts and Caco-2 cells and protected them against oxidative stress damage. In detail, for NPc, the concentration of 400 µg/mL resulted in the most promising to maintain the cell metabolic activity of fibroblasts higher than 90%. Overall, the results reported in this paper support the employment of NPc as a nose-to-brain drug delivery system, as the brain targeting of antioxidants is a potential tool for the therapy of neurological diseases.

scholarly journals MODIFICATION OF GUMS BY PERIODATE OXIDATION: A NATURAL CROSS-LINKER

2019 ◽  
pp. 1-6 ◽  
Author(s):  
Suma Oommen Sen ◽  
Amit Kumar Nayak ◽  
Pritesh Devbhuti ◽  
Amitava Ghosh
Keyword(s):  
Drug Delivery ◽  
Periodate Oxidation ◽  
Staining Technique ◽  
Edible Films ◽  
The Body ◽  
Cross Linking ◽  
Polymeric Structure ◽  
Smart Systems ◽  
Cross Linker ◽  
Natural Cross

Scientists throughout the world are in search of novel modified biopolymer to fabricate smart drug delivery systems based on hydrogel formulations using several cross-linkers like glutaraldehyde, glyoxal, epichlorhydrin, adipic acid dihydrazide, carbodiimide, genipin, etc. Agents that are fused into the polymeric structure like isocyanates, glutaraldehyde, polyepoxides, etc., and are extremely toxic in nature. In addition, these are susceptible to percolate out into the body on biodegradation of polymeric structure. As an alternative to these toxic cross-linking agents, the periodate-Schiff base staining technique is widely being used for cross-linking in biology and biochemistry. The mechanism of this cross-linking technique is based on the reaction in-between the Schiff reagent and the aldehydes produced via the periodate oxidation. During the past few decades, several researchers have already been studied on the natural gums and also, developed their dialdehyde derivatives via the periodate oxidation technique. These periodate oxidized gums are being used to cross-link gelatin, other proteins and chitosan to develop various smart systems for drug delivery, tissue engineering, wound dressing, edible films, etc. The current review presents a comprehensive discussion of the available reported literature on the periodate oxidation of various gums and their use as natural cross-linker.

Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin

2018 ◽  
Vol 350 ◽  
pp. 918-924 ◽  
Author(s):  
Ying-Sui Sun ◽  
Chi-Ya Huang ◽  
Chiang-Sang Chen ◽  
Jean-Heng Chang ◽  
Wen-Tao Hou ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Elastic Modulus ◽  
Bone Cell ◽  
Alloy Surface ◽  
Cell Responses ◽  
Low Elastic Modulus ◽  
Cross Linker ◽  
Natural Cross

Immobilization of Lipase to Chitosan Beads using a Natural Cross‐Linker

2007 ◽  
Vol 37 (3) ◽  
pp. 265-275 ◽  
Author(s):  
Shao‐Hua Chiou ◽  
Tien‐Chieh Hung ◽  
R. Giridhar ◽  
Wen‐Teng Wu
Keyword(s):  
Chitosan Beads ◽  
Cross Linker ◽  
Natural Cross

scholarly journals INVESTIGATION OF PROPERTIES OF NANOFIBERS FROM COLLAGEN AND POLYETHYLENE TEREPHTHALATE USING A NATURAL CROSS-LINKER

2019 ◽  
Vol 53 (3-4) ◽  
pp. 211-218
Author(s):  
MIOARA DROBOTA ◽  
◽  
STELIAN VLAD ◽  
LUIZA GRADINARU ◽  
MARIA BUTNARU ◽  
...  
Keyword(s):  
Polyethylene Terephthalate ◽  
Cross Linker ◽  
Natural Cross
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