scholarly journals Ratiometric Cu2+ Binding, Cell Imaging, Mitochondrial Targeting, and Anticancer Activity with Nanomolar IC50 by Spiro-Indoline-Conjugated Calix[4]arene

ACS Omega ◽  
2019 ◽  
Vol 4 (8) ◽  
pp. 13231-13240 ◽  
Author(s):  
Rahul Nag ◽  
Sirilata Polepalli ◽  
Mohammed Althaf Hussain ◽  
Chebrolu Pulla Rao
Keyword(s):  
Anticancer Activity ◽  
Cell Imaging ◽  
Mitochondrial Targeting ◽  
Binding Cell

Synthesis of α,β-unsaturated benzotriazolyl-1,3,4-oxadiazole derivatives: anticancer activity, cytotoxicity, and cell imaging

2021 ◽  
pp. 1-1
Author(s):  
Juany C. Nava-Ramirez ◽  
Silvia Elena Santana-Krimskaya ◽  
Moises Armides Franco-Molina ◽  
Ana Sofia Ortega-Villarreal ◽  
Israel Lopez ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Imaging ◽  
Oxadiazole Derivatives

A mitochondrial-targeting and NO-based anticancer nanosystem with enhanced photo-controllability and low dark-toxicity

2015 ◽  
Vol 3 (24) ◽  
pp. 4904-4912 ◽  
Author(s):  
Jiangsheng Xu ◽  
Fang Zeng ◽  
Hao Wu ◽  
Shuizhu Wu
Keyword(s):  
Cancer Cells ◽  
Carbon Dots ◽  
Cell Imaging ◽  
High Efficiency ◽  
Mitochondrial Targeting

A spatiotemporally controllable NO-releasing nanosystem for killing cancer cells with high efficiency based on carbon dots has been developed, which exhibits mitochondrial targeting, light-responsive NO-releasing and cell imaging capabilities.

A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

2020 ◽  
Vol 56 (95) ◽  
pp. 15016-15019
Author(s):  
Bo-Xin Zheng ◽  
Meng-Ting She ◽  
Wei Long ◽  
Yong-Yu Xu ◽  
Yi-Han Zhang ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Fluorescent Probe ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
G Quadruplex ◽  
In Cells

A small-sized and target-specific fluorescent probe reveals the presence of c-MYC DNA G4-structures in cells and shows anticancer activity.

Crystal structures of plant inorganic pyrophosphatase, an enzyme with a moonlighting autoproteolytic activity

2019 ◽  
Vol 476 (16) ◽  
pp. 2297-2319 ◽  
Author(s):  
Marta Grzechowiak ◽  
Milosz Ruszkowski ◽  
Joanna Sliwiak ◽  
Kamil Szpotkowski ◽  
Michal Sikorski ◽  
...  
Keyword(s):  
Site Directed Mutagenesis ◽  
Size Exclusion ◽  
Inorganic Pyrophosphatase ◽  
Prolonged Storage ◽  
Mitochondrial Targeting ◽  
Cleavage Rate ◽  
Inorganic Pyrophosphate ◽  
Putative Signal Peptide ◽  
Targeting Peptide

Abstract Inorganic pyrophosphatases (PPases, EC 3.6.1.1), which hydrolyze inorganic pyrophosphate to phosphate in the presence of divalent metal cations, play a key role in maintaining phosphorus homeostasis in cells. DNA coding inorganic pyrophosphatases from Arabidopsis thaliana (AtPPA1) and Medicago truncatula (MtPPA1) were cloned into a bacterial expression vector and the proteins were produced in Escherichia coli cells and crystallized. In terms of their subunit fold, AtPPA1 and MtPPA1 are reminiscent of other members of Family I soluble pyrophosphatases from bacteria and yeast. Like their bacterial orthologs, both plant PPases form hexamers, as confirmed in solution by multi-angle light scattering and size-exclusion chromatography. This is in contrast with the fungal counterparts, which are dimeric. Unexpectedly, the crystallized AtPPA1 and MtPPA1 proteins lack ∼30 amino acid residues at their N-termini, as independently confirmed by chemical sequencing. In vitro, self-cleavage of the recombinant proteins is observed after prolonged storage or during crystallization. The cleaved fragment corresponds to a putative signal peptide of mitochondrial targeting, with a predicted cleavage site at Val31–Ala32. Site-directed mutagenesis shows that mutations of the key active site Asp residues dramatically reduce the cleavage rate, which suggests a moonlighting proteolytic activity. Moreover, the discovery of autoproteolytic cleavage of a mitochondrial targeting peptide would change our perception of this signaling process.

Anticancer activity of resveratrol analogs from Eugenia rigida DC

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
MA Zaki ◽  
V Samoylenko ◽  
S Khan ◽  
RM Abd slam ◽  
MH Hetta ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Resveratrol Analogs
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