scholarly journals Heterometallic BODIPY-Based Molecular Squares Obtained by Self-Assembly: Synthesis and Biological Activities

ACS Omega ◽  
2019 ◽  
Vol 4 (8) ◽  
pp. 13200-13208 ◽  
Author(s):  
Gajendra Gupta ◽  
Yeji You ◽  
Rizky Hadiputra ◽  
Jaehoon Jung ◽  
Dong-Ku Kang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biological Activities ◽  
Molecular Squares

scholarly journals Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3376
Author(s):  
Marco Scarel ◽  
Silvia Marchesan
Keyword(s):  
Drug Discovery ◽  
Enzymatic Hydrolysis ◽  
Self Assembly ◽  
Biological Activities ◽  
Functional Materials ◽  
The Self ◽  
Cyclic Dipeptides ◽  
New Horizons ◽  
Concise Review

Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.

A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging efficacy

2020 ◽  
Vol 56 (94) ◽  
pp. 14861-14864
Author(s):  
Niranjan Meher ◽  
Anil Parsram Bidkar ◽  
Debasish Barman ◽  
Siddhartha Sankar Ghosh ◽  
Parameswar Krishnan Iyer
Keyword(s):  
Self Assembly ◽  
Biological Activities ◽  
Cellular Internalization ◽  
Molecular Systems ◽  
Simple Strategy ◽  
Fine Tune

A simple strategy of conformational manipulation has been unveiled to fine-tune the photophysical and supramolecular self-assembly properties of small molecular systems, which subsequently regulates their biological activities.

Heterometallic Molecular Squares and Polymers Based On Self-Assembly Reactions of Multiply Bonded Dirhenium Complexes

2004 ◽  
Vol 2004 (2) ◽  
pp. 368-375 ◽  
Author(s):  
Jitendra K. Bera ◽  
John Bacsa ◽  
Bradley W. Smucker ◽  
Kim R. Dunbar
Keyword(s):  
Self Assembly ◽  
Dirhenium Complexes ◽  
Multiply Bonded ◽  
Molecular Squares

Luminescent transition-metal-containing cyclophanes (“molecular squares”): covalent self-assembly, host-guest studies and preliminary nanoporous materials applications

1998 ◽  
Vol 171 ◽  
pp. 221-243 ◽  
Author(s):  
Robert V. Slone ◽  
Kurt D. Benkstein ◽  
Suzanne Bélanger ◽  
Joseph T. Hupp ◽  
Ilia A. Guzei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Self Assembly ◽  
Nanoporous Materials ◽  
Molecular Squares

scholarly journals Aβ(M1–40) and Wild-Type Aβ40 Self-Assemble into Oligomers with Distinct Quaternary Structures

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2242 ◽  
Author(s):  
Jacob L. Bouchard ◽  
Taylor C. Davey ◽  
Todd M. Doran
Keyword(s):  
Self Assembly ◽  
Quaternary Structure ◽  
Biological Activities ◽  
Amyloid Β ◽  
Long Term Potentiation ◽  
Wild Type ◽  
Molecular Weights ◽  
Term Potentiation ◽  
Quaternary Structures

Amyloid-β oligomers (AβOs) self-assemble into polymorphic species with diverse biological activities that are implicated causally to Alzheimer’s disease (AD). Synaptotoxicity of AβO species is dependent on their quaternary structure, however, low-abundance and environmental sensitivity of AβOs in vivo have impeded a thorough assessment of structure–function relationships. We developed a simple biochemical assay to quantify the relative abundance and morphology of cross-linked AβOs. We compared oligomers derived from synthetic Aβ40 (wild-type (WT) Aβ40) and a recombinant source, called Aβ(M1–40). Both peptides assemble into oligomers with common sizes and morphology, however, the predominant quaternary structures of Aβ(M1–40) oligomeric states were more diverse in terms of dispersity and morphology. We identified self-assembly conditions that stabilize high-molecular weight oligomers of Aβ(M1–40) with apparent molecular weights greater than 36 kDa. Given that mixtures of AβOs derived from both peptides have been shown to be potent neurotoxins that disrupt long-term potentiation, we anticipate that the diverse quaternary structures reported for Aβ(M1–40) oligomers using the assays reported here will facilitate research efforts aimed at isolating and identifying common toxic species that contribute to synaptic dysfunction.

Self-Assembly Molecular Squares with Metal Complexes as Bridging Ligands

2000 ◽  
Vol 39 (7) ◽  
pp. 1344-1345 ◽  
Author(s):  
Shih-Sheng Sun ◽  
Alexsandra S. Silva ◽  
Ira M. Brinn ◽  
Alistair J. Lees
Keyword(s):  
Metal Complexes ◽  
Self Assembly ◽  
Bridging Ligands ◽  
Molecular Squares

Metal-Mediated Self-Assembly of Molecular Squares of Porphyrins Rimmed with Coordination Compounds

2001 ◽  
Vol 2001 (3) ◽  
pp. 609-612 ◽  
Author(s):  
Elisabetta Iengo ◽  
Romina Minatel ◽  
Barbara Milani ◽  
Luigi G. Marzilli ◽  
Enzo Alessio
Keyword(s):  
Self Assembly ◽  
Coordination Compounds ◽  
Molecular Squares

Deciphering supramolecular isomerization in coordination polymers: connected molecular squares vs fused hexagons

2021 ◽  
Author(s):  
Vijay Gupta ◽  
Biswajit Laha ◽  
Sadhika Khullar ◽  
Sanjay Mandal
Keyword(s):  
Coordination Polymers ◽  
Self Assembly ◽  
The Self ◽  
Ambient Conditions ◽  
Tridentate Ligands ◽  
Molecular Squares

The self-assembly of Mn(II), bis(tridentate) ligands, and bent dicarboxylate linkers under ambient conditions has been exploited to generate a series of 1D coordination polymers in good yields. For a set...

scholarly journals The Development and Lifetime Stability Improvement of Guanosine-Based Supramolecular Hydrogels through Optimized Structure

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Miao Chen ◽  
Weimin Lin ◽  
Le Hong ◽  
Ning Ji ◽  
Hang Zhao
Keyword(s):  
Self Assembly ◽  
Molecular Level ◽  
Biological Activities ◽  
Research Progress ◽  
Self Healing ◽  
Base Modification ◽  
Structural Framework ◽  
Important Building Block ◽  
Targeted Release ◽  
Excess Cations

Guanosine is an important building block for supramolecular gels owing to the unique self-assembly property that results from the unique hydrogen bond acceptors and donor groups. Guanosine-derived supramolecular hydrogels have promise in the fields of drug delivery, targeted release, tissue engineering applications,etc.However, the property of poor longevity and the need for excess cations hinder the widespread applications of guanosine hydrogels. Although guanosine-derived supramolecular hydrogels have been reviewed previously by Dash et al., the structural framework of this review is different, as the modification of guanosine is described at the molecular level. In this review, we summarize the development and lifetime stability improvement of guanosine-based supramolecular hydrogels through optimized structure and elaborate on three aspects: sugar modification, base modification, and binary gels. Additionally, we introduce the concept and recent research progress of self-healing gels, providing inspiration for the development of guanosine-derived supramolecular hydrogels with longer lifespans, unique physicochemical properties, and biological activities.

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