scholarly journals Rational Design of Peptide Ligands Based on Knob–Socket Protein Packing Model Using CD13 as a Prototype Receptor

ACS Omega ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 5126-5136
Author(s):  
Md Zahir Uddin ◽  
Xiaoling Li ◽  
Hyun Joo ◽  
Jerry Tsai ◽  
Lisa Wrischnik ◽  
...  
Keyword(s):  
Rational Design ◽  
Peptide Ligands ◽  
Protein Packing ◽  
Packing Model

Rational Design of Specific High-Affinity Peptide Ligands for the Abl-SH3 Domain†

Biochemistry ◽  
1996 ◽  
Vol 35 (33) ◽  
pp. 10634-10640 ◽  
Author(s):  
M. T. Pisabarro ◽  
L. Serrano
Keyword(s):  
Rational Design ◽  
Sh3 Domain ◽  
Peptide Ligands ◽  
High Affinity ◽  
Affinity Peptide

scholarly journals Picomolar affinity antagonist and sustained signaling agonist peptide ligands for the adrenomedullin and calcitonin gene-related peptide receptors

2020 ◽  
Author(s):  
Jason M. Booe ◽  
Margaret L. Warner ◽  
Augen A. Pioszak
Keyword(s):  
Drug Targets ◽  
Rational Design ◽  
Transmembrane Domain ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Ligands ◽  
Ligand Selectivity ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Receptor Activity Modifying Proteins ◽  
Long Acting

AbstractThe calcitonin receptor-like G protein-coupled receptor (CLR) mediates adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) actions including vasodilation, cardioprotection, and nociception. Receptor activity-modifying proteins (RAMP1-3) determine CLR ligand selectivity through an unresolved mechanism. CLR-RAMP complexes are drug targets, but short AM and CGRP plasma half-lives limit their therapeutic utility. We used combinatorial peptide library and rational design approaches to probe selectivity determinants and develop short AM and CGRP variants with ∼1000-fold increased receptor extracellular domain affinities. Binding and structural studies explained the increased affinities and defined roles for AM Lys46 and RAMP modulation of CLR conformation in selectivity. In longer scaffolds that also bind the CLR transmembrane domain the variants generated picomolar affinity antagonists, one with an estimated 12.5 hr CGRP receptor residence time, and sustained signaling agonists ss-AM and ss-CGRP. This work clarifies the RAMP-modulated ligand selectivity mechanism and provides AM and CGRP variants with promise as long-acting therapeutics.

Rational Design of Peptide Ligands Against a Glycolipid by NMR Studies

2012 ◽  
pp. 39-52 ◽  
Author(s):  
Wenyong Tong ◽  
Tara Sprules ◽  
Kalle Gehring ◽  
H. Uri Saragovi
Keyword(s):  
Rational Design ◽  
Peptide Ligands ◽  
Nmr Studies

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

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