scholarly journals Could Cardiolipin Protect Membranes against the Action of Certain Antimicrobial Peptides? Aurein 1.2, a Case Study

ACS Omega ◽  
2018 ◽  
Vol 3 (12) ◽  
pp. 16453-16464 ◽  
Author(s):  
David Poger ◽  
Sanja Pöyry ◽  
Alan E. Mark
Keyword(s):  
Antimicrobial Peptides ◽  
Aurein 1.2

scholarly journals Lipid-Mediated Polypeptide Interactions in Membranes: Case Study on the Synergism Between Linear Cationic Antimicrobial Peptides

2014 ◽  
Vol 106 (2) ◽  
pp. 441a ◽  
Author(s):  
Evgeniy S. Salnikov ◽  
Elise Glattard ◽  
Hiba Sarrouj ◽  
Arnaud Marquette ◽  
Christopher Aisenbrey ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Cationic Antimicrobial Peptides

scholarly journals AMPing Up the Search: A Structural and Functional Repository of Antimicrobial Peptides for Biofilm Studies, and a Case Study of Its Application to Corynebacterium striatum, an Emerging Pathogen

2021 ◽  
Vol 11 ◽  
Author(s):  
Shreeya Mhade ◽  
Stutee Panse ◽  
Gandhar Tendulkar ◽  
Rohit Awate ◽  
Yatindrapravanan Narasimhan ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
In Silico ◽  
Emerging Pathogen ◽  
Preference Scale ◽  
Modeling Tools ◽  
Interaction Models ◽  
Corynebacterium Striatum

Antimicrobial peptides (AMPs) have been recognized for their ability to target processes important for biofilm formation. Given the vast array of AMPs, identifying potential anti-biofilm candidates remains a significant challenge, and prompts the need for preliminary in silico investigations prior to extensive in vitro and in vivo studies. We have developed Biofilm-AMP (B-AMP), a curated 3D structural and functional repository of AMPs relevant to biofilm studies. In its current version, B-AMP contains predicted 3D structural models of 5544 AMPs (from the DRAMP database) developed using a suite of molecular modeling tools. The repository supports a user-friendly search, using source, name, DRAMP ID, and PepID (unique to B-AMP). Further, AMPs are annotated to existing biofilm literature, consisting of a vast library of over 10,000 articles, enhancing the functional capabilities of B-AMP. To provide an example of the usability of B-AMP, we use the sortase C biofilm target of the emerging pathogen Corynebacterium striatum as a case study. For this, 100 structural AMP models from B-AMP were subject to in silico protein-peptide molecular docking against the catalytic site residues of the C. striatum sortase C protein. Based on docking scores and interacting residues, we suggest a preference scale using which candidate AMPs could be taken up for further in silico, in vitro and in vivo testing. The 3D protein-peptide interaction models and preference scale are available in B-AMP. B-AMP is a comprehensive structural and functional repository of AMPs, and will serve as a starting point for future studies exploring AMPs for biofilm studies. B-AMP is freely available to the community at https://b-amp.karishmakaushiklab.com and will be regularly updated with AMP structures, interaction models with potential biofilm targets, and annotations to biofilm literature.

scholarly journals Interaction of the antimicrobial peptides caerin 1.1 and aurein 1.2 with intact bacteria by 2 H solid-state NMR

2016 ◽  
Vol 1858 (12) ◽  
pp. 2959-2964 ◽  
Author(s):  
Marwa Laadhari ◽  
Alexandre A. Arnold ◽  
Andrée E. Gravel ◽  
Frances Separovic ◽  
Isabelle Marcotte
Keyword(s):  
Solid State ◽  
Antimicrobial Peptides ◽  
Solid State Nmr ◽  
Aurein 1.2

scholarly journals Membrane defects enhance the interaction of antimicrobial peptides, aurein 1.2 versus caerin 1.1

2013 ◽  
Vol 1828 (8) ◽  
pp. 1863-1872 ◽  
Author(s):  
David I. Fernandez ◽  
Marc-Antoine Sani ◽  
Andrew J. Miles ◽  
B.A. Wallace ◽  
Frances Separovic
Keyword(s):  
Antimicrobial Peptides ◽  
Membrane Defects ◽  
Aurein 1.2

scholarly journals N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins

FEBS Letters ◽  
2009 ◽  
Vol 583 (14) ◽  
pp. 2425-2428 ◽  
Author(s):  
Anton A. Polyansky ◽  
Alexander A. Vassilevski ◽  
Pavel E. Volynsky ◽  
Olga V. Vorontsova ◽  
Olga V. Samsonova ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Hemolytic Activity ◽  
Amphipathic Helix

scholarly journals Activity of Antimicrobial Peptides and Conventional Antibiotics against Superantigen Positive Staphylococcus aureus Isolated from the Patients with Neoplastic and Inflammatory Erythrodermia

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Wioletta Baranska-Rybak ◽  
Oscar Cirioni ◽  
Malgorzata Dawgul ◽  
Malgorzata Sokolowska-Wojdylo ◽  
Lukasz Naumiuk ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Peptides ◽  
Therapeutic Implication ◽  
Human Diseases ◽  
High Efficacy ◽  
Opposite Situation ◽  
Conventional Antibiotics ◽  
Aurein 1.2 ◽  
Citropin 1.1 ◽  
Temporin A

Superantigens are proteins comprising a group of molecules produced by various microorganisms. They are involved in pathogenesis of several human diseases. The aim of the study was the comparison of susceptibility to antibiotics and antimicrobial peptides (AMPs) of Staphylococcus aureus (SA) strains producing staphylococcal enterotoxins SEA, SEB, SEC, SED, and TSST-1 and nonproducing ones. In the group of the total 28 of the patients with erythrodermia the presence of SA was confirmed in 24 cases. The total of 14 strains of SA excreted enterotoxins SEA, SEC, SED, and TSST-1. We did not observe that strains producing mentioned superantigens were less susceptible to AMPs (aurein 1.2, citropin 1.1, lipopeptide, protegrin 1, tachyplesin 3, temporin A, and uperin 3.6). The opposite situation was observed in conventional antibiotics. SA strains excreting tested superantigens had higher MICs and MBCs than nonproducing ones. The interesting finding considering the high efficacy of AMPs, against all examined strains of SA, makes them attractive candidates for therapeutic implication.

Design and characterization of new antimicrobial peptides derived from aurein 1.2 with enhanced antibacterial activity

Biochimie ◽  
2021 ◽  
Vol 181 ◽  
pp. 42-51
Author(s):  
Maryam Ramezanzadeh ◽  
Nasrin Saeedi ◽  
Ehsan Mesbahfar ◽  
Parisa Farrokh ◽  
Fatemeh Salimi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antimicrobial Peptides ◽  
Aurein 1.2
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