scholarly journals Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics

ACS Omega ◽  
2018 ◽  
Vol 3 (12) ◽  
pp. 18142-18152 ◽  
Author(s):  
Claudio D. Navo ◽  
Iris A. Bermejo ◽  
Paula Oroz ◽  
Pablo Tovillas ◽  
Ismael Compañón ◽  
...  
Keyword(s):  
Glycosidic Linkage ◽  
Tn Antigen ◽  
Sugar Conformation

scholarly journals Full-Length Transcriptome of Thalassiosira weissflogii as a Reference Resource and Mining of Chitin-Related Genes

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 392
Author(s):  
Haomiao Cheng ◽  
Chris Bowler ◽  
Xiaohui Xing ◽  
Vincent Bulone ◽  
Zhanru Shao ◽  
...  
Keyword(s):  
Cell Wall ◽  
Full Length ◽  
Biosynthetic Pathways ◽  
Glycosidic Linkage ◽  
Thalassiosira Weissflogii ◽  
Ecological Value ◽  
Pacbio Sequencing ◽  
Non Coding Rnas ◽  
Chitin And Chitosan ◽  
Simple Sequence

β-Chitin produced by diatoms is expected to have significant economic and ecological value due to its structure, which consists of parallel chains of chitin, its properties and the high abundance of diatoms. Nevertheless, few studies have functionally characterised chitin-related genes in diatoms owing to the lack of omics-based information. In this study, we first compared the chitin content of three representative Thalassiosira species. Cell wall glycosidic linkage analysis and chitin/chitosan staining assays showed that Thalassiosira weissflogii was an appropriate candidate chitin producer. A full-length (FL) transcriptome of T. weissflogii was obtained via PacBio sequencing. In total, the FL transcriptome comprised 23,362 annotated unigenes, 710 long non-coding RNAs (lncRNAs), 363 transcription factors (TFs), 3113 alternative splicing (AS) events and 3295 simple sequence repeats (SSRs). More specifically, 234 genes related to chitin metabolism were identified and the complete biosynthetic pathways of chitin and chitosan were explored. The information presented here will facilitate T. weissflogii molecular research and the exploitation of β-chitin-derived high-value enzymes and products.

A Double Diastereoselective Michael-Type Addition as an Entry to Conformationally Restricted Tn Antigen Mimics

2013 ◽  
Vol 78 (21) ◽  
pp. 10968-10977 ◽  
Author(s):  
Carlos Aydillo ◽  
Claudio D. Navo ◽  
Jesús H. Busto ◽  
Francisco Corzana ◽  
María M. Zurbano ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Conformationally Restricted ◽  
Michael Type Addition

O-Glycosylation in Echinococcus granulosus: Identification and Characterization of the Carcinoma-Associated Tn Antigen

2001 ◽  
Vol 98 (2) ◽  
pp. 100-109 ◽  
Author(s):  
D Alvarez Errico ◽  
A Medeiros ◽  
M Mı́guez ◽  
C Casaravilla ◽  
R Malgor ◽  
...  
Keyword(s):  
Echinococcus Granulosus ◽  
Tn Antigen ◽  
Identification And Characterization

Enzymatic Synthesis of Glycosphingolipids: A Review

Synthesis ◽  
2021 ◽  
Author(s):  
Qingjiang Li ◽  
Zhongwu Guo
Keyword(s):  
Signal Transduction ◽  
Enzymatic Synthesis ◽  
Biological Activities ◽  
Cell Interaction ◽  
Glycosidic Linkage ◽  
The Past ◽  
Biological Studies ◽  
Hydrophobic Lipid ◽  
Synthetic Methodologies ◽  
And Function

Glycosphingolipids (GSLs) are the major vertebrate glycolipids, which contain two distinctive moieties, a glycan and a ceramide, stitched together by a β-glycosidic linkage. The hydrophobic lipid chains of ceramide can insert into the cell membrane to form “lipid rafts” and anchor the hydrophilic glycan onto the cell surface to generate microdomains and function as signaling molecules. GSLs mediate signal transduction, cell interaction, and many other biological activities, and are also related to many diseases. To meet the need of biological studies, chemists have developed various synthetic methodologies to access GSLs. Among them, the application of enzymes to GSL synthesis has witnessed significant advancements in the past decades. This review summarizes briefly the history and progress of enzymatic GSL synthesis.

Hydroxyproline-O-glycosidic Linkage of the Plant Cell Wall Glycoprotein Extensin

Nature ◽  
1967 ◽  
Vol 216 (5122) ◽  
pp. 1322-1324 ◽  
Author(s):  
DEREK T. A. LAMPORT
Keyword(s):  
Cell Wall ◽  
Plant Cell ◽  
Plant Cell Wall ◽  
Glycosidic Linkage
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