scholarly journals Redox Modulators Determine Luminol Luminescence Generated by Porphyrin-Coordinated Iron and May Repress “Suicide Inactivation”

ACS Omega ◽  
2018 ◽  
Vol 3 (9) ◽  
pp. 12295-12303 ◽  
Author(s):  
Christoph Plieth
Keyword(s):  
Suicide Inactivation

Suicide inactivation of bacterial cystathionine .gamma.-synthase and methionine .gamma.-lyase during processing of L-propargylglycine

Biochemistry ◽  
1979 ◽  
Vol 18 (21) ◽  
pp. 4690-4701 ◽  
Author(s):  
Michael Johnston ◽  
Dorian Jankowski ◽  
Patrick Marcotte ◽  
Hidehiko Tanaka ◽  
Nobuyoshi Esaki ◽  
...  
Keyword(s):  
Suicide Inactivation ◽  
Methionine Gamma Lyase

scholarly journals Suicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide

2001 ◽  
Vol 358 (2) ◽  
pp. 325 ◽  
Author(s):  
Ben L. J. GODBER ◽  
Justin J. DOEL ◽  
Tracey A. GOULT ◽  
Robert EISENTHAL ◽  
Roger HARRISON
Keyword(s):  
Nitric Oxide ◽  
Xanthine Oxidoreductase ◽  
Suicide Inactivation

Suicide inactivation of aromatase in human placenta and uterine leiomyoma by 5α-dihydronorethindrone, a metabolite of norethindrone, and its effect on steroid-producing enzymes

1994 ◽  
Vol 130 (6) ◽  
pp. 634-640 ◽  
Author(s):  
Takara Yamamoto ◽  
Takaya Tamura ◽  
Jo Kitawaki ◽  
Yoshio Osawa ◽  
Hiroji Okada
Keyword(s):  
Human Placenta ◽  
Uterine Leiomyoma ◽  
High Dose ◽  
Aromatase Activity ◽  
Dependent Manner ◽  
Chain Cleavage ◽  
Time Period ◽  
Suicide Inactivation

Yamamoto T, Tamura T, Kitawaki J, Osawa Y, Okada H. Suicide inactivation of aromatase in human placenta and uterine leiomyoma by 5α-dihydronorethindrone, a metabolite of norethindrone, and its effect on steroid-producing enzymes. Eur J Endocrinol 1994;130:634–40. ISSN 0804–4643 Norethindrone (NET; 17α-ethynyl-19-nortestosterone), a progestogen component of the contraceptive pill, irreversibly inhibits aromatase activity in human placental microsomes. However, it is known also to be aromatized in vitro and in vivo to produce a biologically very active estrogen called ethynylestradiol (EE2). It is therefore inappropriate to administer a high dose of NET to estrogendependent cancer patients for a prolonged time period. In this study, we focused on 5α-dihydronorethindrone (5α-DHNET), a metabolite of NET that is not aromatizable, and the inhibitory effects of 5α-DHNET on human placental and uterine leiomyoma microsomal aromatase and other steroid synthetases. 5α-Dihydronorethindrone showed weak affinity for both estrogen and progestogen receptors. It inhibited significantly human placental aromatase activity in a dose-dependent manner (Ki = 9.0 μmol/l; Kinact = 0.024/min), as well as that of uterine leiomyoma, but did not influence cholesterol side-chain cleavage or 17α-hydroxylase, 21-hydroxylase or 11β-hydroxylase activities. These results suggest that 5α-DHNET may be useful as an aromatase inhibitor, whose use in large doses is expected to reduce the size of estrogen-dependent tumors. Takara Yamamoto, Department of Obstetrics and Gynecology, Kawaramachi-Hirokoji, Kamikyo-Ku, Kyoto 602, Japan

Kinetic study in the transient phase of the suicide inactivation of frog epidermis tyrosinase

1988 ◽  
Vol 30 (3) ◽  
pp. 303-310 ◽  
Author(s):  
José Tudela ◽  
Francisco Garcia Cánovas ◽  
Ramón Varón ◽  
Mercedes Jiménez ◽  
Francisco Garcia-Carmona ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Transient Phase ◽  
Suicide Inactivation

scholarly journals Mechanistic Basis for Suicide Inactivation of Porphobilinogen Synthase by 4,7-Dioxosebacic Acid, an Inhibitor That Shows Dramatic Species Selectivity†

Biochemistry ◽  
2001 ◽  
Vol 40 (28) ◽  
pp. 8227-8236 ◽  
Author(s):  
Jukka Kervinen ◽  
Eileen K. Jaffe ◽  
Frédéric Stauffer ◽  
Reinhard Neier ◽  
Alexander Wlodawer ◽  
...  
Keyword(s):  
Species Selectivity ◽  
Suicide Inactivation ◽  
Porphobilinogen Synthase ◽  
Mechanistic Basis
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