scholarly journals Structural Motif Descriptors as a Way To Elucidate the Agonistic or Antagonistic Activity of Growth Hormone–Releasing Hormone Peptide Analogues

ACS Omega ◽  
2018 ◽  
Vol 3 (7) ◽  
pp. 7432-7440 ◽  
Author(s):  
Kevin Jeanne Dit Fouque ◽  
Luis M. Salgueiro ◽  
Renzhi Cai ◽  
Wei Sha ◽  
Andrew V. Schally ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Antagonistic Activity ◽  
Structural Motif ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Peptide Analogues

New analogs of human growth hormone-releasing hormone (1-29) with high and prolonged antagonistic activity

2009 ◽  
Vol 51 (2) ◽  
pp. 134-141 ◽  
Author(s):  
KATALIN TOTH ◽  
MAGDOLNA KOVACS ◽  
MARTA ZARANDI ◽  
GABOR HALMOS ◽  
KATE GROOT ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Antagonistic Activity ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Treatment with growth hormone-releasing hormone (GHRH) 1-44 stimulates growth velocity in growth hormone-deficient children

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S85-S86
Author(s):  
Y.-F. SHI ◽  
X.-L. BAO ◽  
R. Liu ◽  
J.-Y. DENG ◽  
W. REINHARDT ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Velocity ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone
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