scholarly journals Temperature- and Composition-Dependent DNA Condensation by Thermosensitive Block Copolymers

ACS Omega ◽  
2017 ◽  
Vol 2 (11) ◽  
pp. 7946-7958 ◽  
Author(s):  
Satyagopal Sahoo ◽  
Sharmita Bera ◽  
Saikat Maiti ◽  
Dibakar Dhara
Small ◽  
2011 ◽  
Vol 7 (12) ◽  
pp. 1683-1689 ◽  
Author(s):  
Kiyofumi Katagiri ◽  
Yuji Imai ◽  
Kunihito Koumoto ◽  
Tomohiro Kaiden ◽  
Kenji Kono ◽  
...  

2005 ◽  
Vol 5 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Xiangrong Chen ◽  
Xiaobin Ding ◽  
Zhaohui Zheng ◽  
Yuxing Peng

Soft Matter ◽  
2011 ◽  
Vol 7 (6) ◽  
pp. 2687 ◽  
Author(s):  
Francesca Ercole ◽  
Simon Harrisson ◽  
Thomas P. Davis ◽  
Richard A. Evans

2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.


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