scholarly journals Ru-NHC Catalyzed Domino Reaction of Carbonyl Compounds and Alcohols: A Short Synthesis of Donaxaridine

ACS Omega ◽  
2017 ◽  
Vol 2 (11) ◽  
pp. 8234-8252 ◽  
Author(s):  
Girish Singh Bisht ◽  
Moreshwar Bhagwan Chaudhari ◽  
Vruta Sunil Gupte ◽  
Boopathy Gnanaprakasam
Keyword(s):  
Carbonyl Compounds ◽  
Domino Reaction ◽  
Short Synthesis

Lewis-Base-Catalyzed Domino Reaction of Morita-Baylis-Hillman Carbonates of Isatins with Enolizable Cyclic Carbonyl Compounds: Stereoselective Access to Spirooxindole-Pyrans

2018 ◽  
Vol 7 (8) ◽  
pp. 1595-1599 ◽  
Author(s):  
Anubha Yadav ◽  
Joyanta Banerjee ◽  
Sanjeeva K. Arupula ◽  
Shaikh M. Mobin ◽  
Sampak Samanta
Keyword(s):  
Carbonyl Compounds ◽  
Lewis Base ◽  
Domino Reaction

A short synthesis of α-allenic alcohols from α,β-unsaturated carbonyl compounds with dichloromethyl p-tolyl sulfoxide

2008 ◽  
Vol 49 (39) ◽  
pp. 5689-5692 ◽  
Author(s):  
Tsuyoshi Satoh ◽  
Takafumi Noguchi ◽  
Toshifumi Miyagawa
Keyword(s):  
Carbonyl Compounds ◽  
Short Synthesis

Diversity oriented, efficient and sustainable synthetic protocol for the synthesis of structurally diverse drug-like complex heterocycles, incorporating privileged heterocyclic systems

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Sarita Khandelwal ◽  
Anshu Rajawat ◽  
Yogesh Kumar Tailor ◽  
Hemant Kumar Jain ◽  
Mahendra Kumar
Keyword(s):  
Carbonyl Compounds ◽  
Structural Complexity ◽  
Sulfamic Acid ◽  
Acid Catalyst ◽  
Catalytic Amount ◽  
Domino Reaction ◽  
Synthetic Strategy

AbstractA diversity oriented, efficient and sustainable synthetic protocol has been presented for the synthesis of structurally diverse drug-like small heterocycles with structural complexity. The present synthetic strategy involves a three-component domino reaction of 2-aminobenzothiazoles, thiophene-2-carbaldehyde and carbonyl compounds in the presence of a catalytic amount of sulfamic acid as a recyclable ecofriendly acid catalyst.

Silicon Assisted Sulfuration: Tetrachlorosilane-Sodium Sulfide-A New Potent Thionating Reagent for Carbonyl Compounds

2007 ◽  
Author(s):  
T. A. Salama ◽  
S. S. Elmorsy ◽  
A. M. Khalil ◽  
M. A. Ismail ◽  
A. S. El-Ahl
Keyword(s):  
Carbonyl Compounds ◽  
Sodium Sulfide

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Directed, Palladium(II)-Catalyzed Enantioselective anti-Carboboration of Alkenyl Carbonyl Compounds

2019 ◽  
Author(s):  
Zhen Liu ◽  
Xiaohan Li ◽  
Tian Zeng ◽  
Keary Engle
Keyword(s):  
Carbonyl Compounds ◽  
Building Blocks ◽  
New Method ◽  
Carbon Based

A substrate-directed enantioselective <i>anti</i>-carboboration reaction of alkenes has been developed, wherein a carbon based nucleophile and a boron moiety are installed across the C=C bond through a 5- or 6-membered palladacycle intermediate. The reaction is promoted by a palladium(II) catalyst and a mondentate oxzazoline ligand. A range of enantioenriched secondary alkylboronate products were obtained with moderate to high enantioselectivity that could be further upgraded by recrystallization. This work represents a new method to synthesize versatile and valuable alkylboronate building blocks. Building on an earlier mechanistic proposal by Peng, He, and Chen, a revised model is proposed to account for the stereoconvergent nature of this transformation.

A Short Synthesis of (+)-Brefeldin C via Enantioselective Radical Hydroalkynylation

2019 ◽  
Author(s):  
Lars Gnägi ◽  
Severin Vital Martz ◽  
Daniel Meyer ◽  
Robin Marc Schärer ◽  
Philippe Renaud
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Oxidation State ◽  
Single Step ◽  
Radical Process ◽  
Target Molecule ◽  
Short Synthesis ◽  
The One

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach is based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use of a furan substituent allows to achieve a high trans diastereoselectivity during the radical process and it contains the four carbon atoms C1–C4 of the natural product in an oxidation state closely related to the one of the target molecule. The eight-step synthesis require six product purifications and it provides (+)-brefeldin C in 18% overall yield.</p></div></div></div></div>

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