scholarly journals Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity

ACS Omega ◽  
2017 ◽  
Vol 2 (10) ◽  
pp. 6741-6754 ◽  
Author(s):  
Xueke She ◽  
Andrea Pegoli ◽  
Judith Mayr ◽  
Harald Hübner ◽  
Günther Bernhardt ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Receptor Ligands ◽  
Muscarinic Acetylcholine

scholarly journals Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity

2020 ◽  
Vol 11 (7) ◽  
pp. 823-832 ◽  
Author(s):  
Corinna G. Gruber ◽  
Andrea Pegoli ◽  
Christoph Müller ◽  
Lukas Grätz ◽  
Xueke She ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Fluorescent Dyes ◽  
Muscarinic Acetylcholine Receptor ◽  
Molecular Tools ◽  
Receptor Ligands ◽  
Binding Studies ◽  
Receptor Affinity ◽  
Muscarinic Acetylcholine ◽  
Flow Cytometric ◽  
Saturation Binding

New fluorescent molecular tools for the muscarinic acetylcholine M2 receptor, bearing various fluorescent dyes, showed high M2 receptor affinity in flow cytometric saturation binding studies at CHO–hM2R cells (pKd > 8.3).

Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity

2019 ◽  
Vol 62 (11) ◽  
pp. 5358-5369 ◽  
Author(s):  
Andrea Pegoli ◽  
David Wifling ◽  
Corinna G. Gruber ◽  
Xueke She ◽  
Harald Hübner ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Short Peptides ◽  
Receptor Ligands ◽  
Muscarinic Acetylcholine
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