scholarly journals Glycopolypeptide-Grafted Bioactive Polyionic Complex Vesicles (PICsomes) and Their Specific Polyvalent Interactions

ACS Omega ◽  
2016 ◽  
Vol 1 (4) ◽  
pp. 600-612 ◽  
Author(s):  
Bhawana Pandey ◽  
Jaladhar Mahato ◽  
Karishma Berta Cotta ◽  
Soumen Das ◽  
Dharmendar Kumar Sharma ◽  
...  
Keyword(s):  
Polyionic Complex

Fabrication of Cell Outer Membrane Mimetic Surfaces on Chitosan Nanoparticles by Polyionic Complex and Template Polymerization

2014 ◽  
Vol 618 ◽  
pp. 335-338 ◽  
Author(s):  
Ming Gong ◽  
Zhu Feng Li ◽  
Qi Wang ◽  
Kai Li Sheng ◽  
Xiao Qin Wang ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Outer Membrane ◽  
Methacrylic Acid ◽  
Chitosan Nanoparticles ◽  
Template Polymerization ◽  
Transmission Electron ◽  
Membrane Mimetic ◽  
A Cell ◽  
Copolymer Poly ◽  
Polyionic Complex

The polyanion of copolymer poly (2-methacryloyloxyethyl phosphorylcholine-co-methacrylic acid) (PMA30) was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylic acid (MA). The synthesized PMA30 was assembled on chitosan (CS) surfaces formation of chitosan nanoparticles by polyionic complex. The chitosan nanoparticle was prepared using methacrylic acid (MA), 2-methacryloyloxyethyl phosphorylcholine (MPC) by template polymerization. The size distribution and structure properties of chitosan nanoparticles were characterized by scanning electron microscopy (SEM), dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential. These results show that a cell outer membrane mimetic surface was formed on the chitosan nanoparticles, which provides an effective way to improve the biocompatibility of chitosan nanoparticles.

Sterically stabilized polyionic complex nanogels of chitosan lysate and PEG-b-polyglutamic acid copolymer for delivery of irinotecan active metabolite (SN-38)

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen Salmanpour ◽  
Mahvand Saeed-Vaghefi ◽  
Samira Sadat Abolmaali ◽  
Alimohamad Tamaddon
Keyword(s):  
Glutamic Acid ◽  
Active Metabolite ◽  
Drug Loading ◽  
Free Particle ◽  
Hydrolytic Degradation ◽  
Weight Ratio ◽  
Size Exclusion ◽  
Spherical Particles ◽  
Wide Range ◽  
Polyionic Complex

Background:: Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copolymers (PEG-b-PGlu) are interesting biocompatible and biodegradable candidates bearing carboxylic acid functional groups. Objectives:: Aiming to solubilize and to preserve short-acting irinotecan active metabolite (SN38), sterically stabilized PIC nanogels were prepared through electrostatic charge neutralization between PEG-b-PGlu and chitosan lysate, a polycationic natural polymer obtained through digestion of chitosan by hydrogen peroxide oxidation and is soluble in a wide range of pH. Methods:: Synthesis of PEG-b-PGlu was accomplished by N-carboxyanhydride polymerization of γ -benzyl L-glutamic acid, which is initiated by methoxy PEG-NH2 and successive debenzylation reaction. Result:: The resulting block copolymer was characterized by FTIR, 1H-NMR, and Size Exclusion Chromatography (SEC). Self-assembling properties of the PIC nanogels were investigated by pyrene assay, Dynamic Light Scattering (DLS), and Transmission Electron Microscopy (TEM), indicating formation of homogeneous spherical particles with a mean size of 28 nm at the PEG-b-PGlu concentrations/LMWC weight ratio of 5:1. Upon direct loading of SN38, the drug solubility enhanced more than 4×103 folds with a mean loading efficiency of 89% and the drug loading of 30%. PIC nanogels exhibited zeta potential of +1 mV, acceptable biocompatibility, and superior cytotoxicity in murine colorectal carcinoma (CT26 cell line) compared to free drug. Conclusion:: In addition, the PIC nanogels provided SN38 protection against hydrolytic degradation in physiologic condition. Conclusively, the well-tuned PIC nanogels are suggested as a potential biocompatible nanocarrier for SN38 delivery.

In vitro andin vivo biocompatibility of chitosan-xanthan polyionic complex

2000 ◽  
Vol 51 (1) ◽  
pp. 107-116 ◽  
Author(s):  
Fatiha Chellat ◽  
Maryam Tabrizian ◽  
Severian Dumitriu ◽  
Esteban Chornet ◽  
Pierre Magny ◽  
...  
Keyword(s):  
Polyionic Complex

Inside Cover: Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm (Angew. Chem. Int. Ed. 29/2009)

2009 ◽  
Vol 48 (29) ◽  
pp. 5220-5220 ◽  
Author(s):  
Yan Lee ◽  
Takehiko Ishii ◽  
Horacio Cabral ◽  
Hyun Jin Kim ◽  
Ji-Hun Seo ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Complex Micelles ◽  
Polyionic Complex
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