scholarly journals Gallium-68 Labeling of the Cyclin-Dependent Kinase 4/6 Inhibitors as Positron Emission Tomography Radiotracers for Tumor Imaging

ACS Omega ◽  
2021 ◽  
Author(s):  
Cheng Liu ◽  
Ziyi Yang ◽  
Mingyu Liu ◽  
Xiangwei Wang ◽  
Shaoli Song ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Cyclin Dependent Kinase ◽  
Positron Emission ◽  
Gallium 68

Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography

2010 ◽  
Vol 18 (21) ◽  
pp. 7338-7347 ◽  
Author(s):  
Dinesh Shetty ◽  
Jae Min Jeong ◽  
Chang Hwan Ju ◽  
Young Ju Kim ◽  
Ji-Youn Lee ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Amino Acid ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Amino Acid Derivatives ◽  
Positron Emission ◽  
Gallium 68

scholarly journals Biodistribution of phenylalanine labeled with gallium-68

2021 ◽  
Vol 2058 (1) ◽  
pp. 012040
Author(s):  
V K Tishchenko ◽  
V M Petriev ◽  
E D Stepchenkova
Keyword(s):  
Positron Emission Tomography ◽  
Tumor Imaging ◽  
High Sensitivity ◽  
Comparative Investigation ◽  
Emission Tomography ◽  
Tumor Uptake ◽  
Agent Based ◽  
Positron Emission ◽  
Gallium 68 ◽  
Sensitivity Method

Abstract Positron emission tomography (PET) is modern high sensitivity method of various tumor imaging. The synthesis of new radiopharmaceuticals based on amino acids and positron emitting radionuclide 68Ga for PET imaging is of great interest. This work is devoted to study the biodistribution of a new agent based on amino acid phenylalanine and 68Ga (68Ga-phenylalanine) in Wistar rats with cholangioma RS-1 after intravenous administration. A comparative investigation of 68Ga-phenylalanine and 68GaCl3 biodistribution was also carried out. It was shown that the highest uptake of 68Ga-phenylalanine was observed in blood, liver, femur and tumor. Tumor uptake of 68Ga-phenylalanine increased 3.5 times from 0.20 ± 0.03 % ID/g to 0.70 ± 0.10 % ID/g, whereas uptake of 68GaCl3 decreased from 0.34 ± 0.07 % ID/g to 0.13 ± 0.04 % ID/g within 3 h. Blood uptake of 68Ga-phenylalanine reached 2.98 ± 0.31 % ID/g. In other organs and tissues the uptake of 68Ga-phenylalanine didn’t exceed 1 % ID/g. Kidneys and femur uptake of 68Ga-phenylalanine was lower as compared with 68GaCl3, but in other organs the uptake of 68Ga-phenylalanine was similar or slightly higher when compared with 68GaCl3.

BRAIN TUMOR IMAGING BASED ON C-11 LABELED AMINO ACID UTILIZATION USING POSITRON EMISSION TOMOGRAPHY

1980 ◽  
Vol 15 (5) ◽  
pp. 380
Author(s):  
C Leon Partain ◽  
Karl F. Hubner ◽  
M. Stephen Mahaley ◽  
F. David Rollo ◽  
Ronald R. Price ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Tumor ◽  
Amino Acid ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Positron Emission ◽  
Amino Acid Utilization

Comparison between gallium‐68 citrate positron emission tomography‐computed tomography and gallium‐67 citrate scintigraphy for infection imaging

2019 ◽  
Vol 49 (8) ◽  
pp. 1016-1022 ◽  
Author(s):  
Tatiana Segard ◽  
Laurence M. J. A. Morandeau ◽  
Marina L. Dunne ◽  
James O. Robinson ◽  
Ronan J. Murray ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Infection Imaging ◽  
Positron Emission ◽  
Gallium 68 ◽  
Gallium 67

scholarly journals Nuclear Imaging of Glucose Metabolism: Beyond 18F-FDG

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Han Feng ◽  
Xiaobo Wang ◽  
Jian Chen ◽  
Jing Cui ◽  
Tang Gao ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Tumor Imaging ◽  
Single Photon ◽  
Photon Emission ◽  
Nuclear Imaging ◽  
Emission Tomography ◽  
Metabolic Imaging ◽  
Emission Computed Tomography ◽  
Positron Emission

Glucose homeostasis plays a key role in numerous fundamental aspects of life, and its dysregulation is associated with many important diseases such as cancer. The atypical glucose metabolic phenomenon, known as the Warburg effect, has been recognized as a hallmark of cancer and serves as a promising target for tumor specific imaging. At present, 2-deoxy-2-[18F]fluoro-glucose (18F-FDG)-based positron emission tomography/computed tomography (PET/CT) represented the state-of-the-art radionuclide imaging technique for this purpose. The powerful impact of 18F-FDG has prompted intensive research efforts into other glucose-based radiopharmaceuticals for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging. Currently, glucose and its analogues have been labeled with various radionuclides such as 99mTc, 111In, 18F, 68Ga, and 64Cu and have been successfully investigated for tumor metabolic imaging in many preclinical studies. Moreover, 99mTc-ECDG has advanced into its early clinical trials and brings a new era of tumor imaging beyond 18F-FDG. In this review, preclinical and early clinical development of glucose-based radiopharmaceuticals for tumor metabolic imaging will be summarized.

Sign in / Sign up

Export Citation Format

Share Document