scholarly journals “Efficacy–Nature–Structure” Relationship of Traditional Chinese Medicine Based on Chemical Structural Data and Bioinformatics Analysis

ACS Omega ◽  
2021 ◽  
Author(s):  
Xin-Xin Shao ◽  
Cong Chen ◽  
Meng-Meng Liang ◽  
Zhi-yuan Yu ◽  
Feng-Cong Zhang ◽  
...  
2015 ◽  
Vol 43 (08) ◽  
pp. 1515-1524 ◽  
Author(s):  
Lin-Hua Zha ◽  
Li-Sha He ◽  
Feng-Mei Lian ◽  
Zhong Zhen ◽  
Hang-Yu Ji ◽  
...  

The clinical therapeutics of traditional Chinese medicine (TCM) constitutes a complicated process which involves theory, diagnosis, and formula prescription with specific herbal dosage. Zhang Zhong-Jing’s classic work, Treatise on Febrile and Miscellaneous Diseases, has been influencing TCM practice for almost 2000 years. However, during this extended period of time in Chinese history, the Chinese weight measurement system experienced noticeable changes. This change in the weight measurement system inevitably, and perhaps even negatively, affected TCM herbal dosage determination and treatment outcome. Thus, in modern society, a full understanding of the accuracy of herbal dose selection has a critical importance in the TCM daily practice of delivering the best treatment to the patients suffering from different illnesses. In the 973 Project of the Chinese National Basic Research Program, expert consensus on classic TCM formula dose conversion has been reached based on extensive literature review and discussion on the dose–effect relationship of classic TCM formulas. One “liang” (两) in classic TCM formulas is equivalent to 13.8[Formula: see text]g. However, based on many TCM basic and clinical studies of variable herbal formula prescriptions and herbal drug preparations, the rule of one liang equals 13.8[Formula: see text]g should be adjusted according to different disease conditions. Recommended by the committee on TCM formula dose–effect relationship of the China Association of Chinese Medicine and the World Federation of Chinese Medicine Societies, the following expert consensus has been reached: (i) One liang converts to 6–9[Formula: see text]g for the severely and critically ill patients. (ii) One liang converts to 3–6[Formula: see text]g for the patients suffering from chronic diseases. (iii) One liang converts to 1–3[Formula: see text]g in preventive medicine. The above conversions should be used as a future TCM practice guideline. Using this recommended guideline should enhance the effectiveness of daily TCM practice.


2021 ◽  
Vol 27 ◽  
Author(s):  
Li-Ping Yu ◽  
Ting-Ting Shi ◽  
Yan-Qin Li ◽  
Jian-Kang Mu ◽  
Ya-Qin Yang ◽  
...  

: Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.


2022 ◽  
pp. 270-291
Author(s):  
Akash ◽  
Navneet ◽  
Bhupendra Singh Bhandari ◽  
Surendra Singh Bisht ◽  
Dalip Kumar Mansotra

Traditional medicines and natural products from ethnomedicinal plants have great significance in recent time. Various forms of medicines like Ayurveda, traditional Chinese medicine, kampo, Unani, have been plasticising in recent days due to their effectiveness against various human ailments and also have blossomed into the regulated systems of traditional medicine. This chapter reviews the relationship of plants and humans, along with their cultural relationship and role of the traditional medicines, by exploring the methodologies and various concepts for the discovery of various drugs. Further, this will also illustrate traditional medicines that have their incomparable advantages over the modern allopathic medicines.


2016 ◽  
Vol 14 (3) ◽  
pp. 309-315
Author(s):  
Hong Meng ◽  
Yifan He ◽  
Xiaoyang Zheng ◽  
Wenyi Zhu ◽  
Yinmao Dong

Author(s):  
G. Chuprina ◽  
T. Parnikoza ◽  
N. Svyrydova

The theory of the five elements is widely used in traditional Chinese medicine, and the division of natural phenomena according to the properties of the five elements and the nature of the relationship between them, is practical in clinical acupuncture: to characterize the structural, physiological and pathological features of the patient, diagnosis and treatment. With the development of diseases there is a pathological relationship between Zhang-Fu organs and tissues that they are subordinated to. The human body is an organic whole, in which there are numerous interconnections in the development of the pathological process due to the existing modified interconnections. It is established that the theory of five elements is a simple theory with certain limitations. The laws of the relationship between the elements of the U-Syin cycle are not a reflection of all possible interconnections between the Zhang-Fu organs and the related tissues. In clinical practice, these laws show objective physiological and pathological communications between the internal organs and can be used in the process of acupuncture diagnosis and treatment. The theory of the five elements lies at the heart of the methodology of traditional acupuncture diagnostics, used during its implementation and data analysis, it determines the pathological states in accordance with the characteristics and laws of the relationship of the five elements and formulates the syndromic diagnosis of traditional Chinese Medicine (TCM).


2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Shunhua Teng ◽  
Guoyong Ma ◽  
Guozhong Lyu

Objective — It’s to study the dose-effect relationship of moxa produced by Gansu Baicao Group in the air disinfection in traditional Chinese medicine clinics. Method — Use moxa sticks burning fumigation to disinfect indoor air in the clinics of traditional Chinese medicine experts; use the natural sedimentation method to detect the bacterial content in the air; compare the sterilization effects of 0.5, 1 and 1.5 moxa sticks 0 h, 1 h and 2 h after air disinfection. Results — In the 54m3 TCM clinic, there was no significant difference in the sterilization rate of air bacteria 0h, 1h, and 2h after using 1 moxa stick and 1.5 moxa sticks respectively for fumigation and disinfection (P>0.05). There was a significant difference in the sterilization rate of air bacteria between 1 moxa stick group and 0.5 moxa stick group 0 h after air disinfection (P < 0. 05). There was a significant difference in the sterilization rate of air bacteria between 0 hour and 1 hour after burning fumigation for air disinfection in 0.5 moxa group (P < 0. 05). Conclusion — The best dose of moxa burning fumigation for air disinfection in 54m3 Chinese medicine clinic is 0.5 stick; the best time for air disinfection is 1h after disinfection.


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