scholarly journals Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma

ACS Omega ◽  
2021 ◽  
Author(s):  
Colin Hastie ◽  
Adrian Thompson ◽  
Mark Perkins ◽  
Vaughan S. Langford ◽  
Michael Eddleston ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Flow Tube ◽  
Ion Flow ◽  
Chromatography Mass Spectrometry ◽  
Selected Ion Flow Tube

Combined use of gas chromatography and selected ion flow tube mass spectrometry for absolute trace gas quantification

2006 ◽  
Vol 20 (4) ◽  
pp. 563-567 ◽  
Author(s):  
Jiří Kubišta ◽  
Patrik Španěl ◽  
Kseniya Dryahina ◽  
Clive Workman ◽  
David Smith
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Trace Gas ◽  
Flow Tube ◽  
Ion Flow ◽  
Combined Use ◽  
Selected Ion Flow Tube

scholarly journals Addition of fast gas chromatography to selected ion flow tube mass spectrometry for analysis of individual monoterpenes in mixtures

2019 ◽  
Vol 12 (9) ◽  
pp. 4965-4982 ◽  
Author(s):  
Michal Lacko ◽  
Nijing Wang ◽  
Kristýna Sovová ◽  
Pavel Pásztor ◽  
Patrik Španěl
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Limit Of Detection ◽  
Headspace Analysis ◽  
Total Sample ◽  
Ionization Mass ◽  
Flow Tube ◽  
Ion Flow ◽  
Fast Gas Chromatography ◽  
Selected Ion Flow Tube

Abstract. Soft chemical ionization mass spectrometry (SCI-MS) techniques can be used to accurately quantify volatile organic compounds (VOCs) in air in real time; however, differentiation of isomers still represents a challenge. A suitable pre-separation technique is thus needed, ideally capable of analyses over a few tens of seconds. To this end, a bespoke fast gas chromatography (GC) instrument with an electrically heated 5 m long metallic capillary column was coupled to selected ion flow tube mass spectrometry (SIFT-MS) measurements. To assess the performance of this combination, a case study of monoterpene isomer (C10H16) analyses was carried out. The monoterpenes were quantified by SIFT-MS using H3O+ reagent ions (analyte ions C10H17+, m∕z 137, and C6H9+, m∕z 81) and NO+ reagent ions (analyte ions C10H16+, m∕z 136, and C7H9+, m∕z 93). The combinations of the fragment ion relative intensities obtained using H3O+ and NO+ were shown to be characteristic of the individual monoterpenes. Two non-polar GC columns (Restek Inc.) were tested: the advantage of MXT-1 was shorter retention, whilst the advantage of MXT-Volatiles was better separation. Thus, it is possible to identify components of a monoterpene mixture in less than 45 s using the MXT-1 column and to separate them in less than 180 s using the MXT-Volatiles column. Quality of the separation and the sensitivity of present technique (limit of detection, LOD, ∼16 ppbv) was found to be inferior compared to commercially available fast GC solutions coupled with proton transfer reaction mass spectrometry (PTR-MS, LOD ∼1 ppbv) due to the limited sample flow through the column. However, using combinations of two reagent ions improved identification of monoterpenes not well resolved by the chromatograms. As an illustrative example, the headspace of needle samples of three conifer species was analysed by both reagent ions and with both columns showing that mainly α-pinene, β-pinene and 3-carene were present. The system can thus be used for direct rapid monitoring of monoterpenes above 20 ppbv, such as applications in laboratory studies of monoterpene standards and leaf headspace analysis. Limitation of the sensitivity due to the total sample flow can be improved using a multi-column pre-separation.

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