scholarly journals Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

ACS Omega ◽  
2021 ◽  
Vol 6 (34) ◽  
pp. 21843-21849
Author(s):  
Andrea Citarella ◽  
Davide Moi ◽  
Luca Pinzi ◽  
Davide Bonanni ◽  
Giulio Rastelli
Keyword(s):  
Hydroxamic Acid ◽  
Medicinal Chemistry ◽  
Hydroxamic Acid Derivatives

scholarly journals Cross metathesis-mediated synthesis of hydroxamic acid derivatives

2018 ◽  
Vol 14 ◽  
pp. 3070-3075 ◽  
Author(s):  
Shital Kumar Chattopadhyay ◽  
Subhankar Ghosh ◽  
Suman Sil
Keyword(s):  
Hydroxamic Acid ◽  
Cyclic Peptide ◽  
Alternative Synthesis ◽  
Acid Component ◽  
Cross Metathesis ◽  
Reaction Proceeds ◽  
Amino Acid Component ◽  
Short Time ◽  
Unusual Amino Acid ◽  
Hydroxamic Acid Derivatives

An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N-benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs’ second generation catalyst within short time and in good yields (57–85%) with a range of substrates. Subsequent hydrogenation of each of the CM products delivers the title compounds in moderate to very good yield (70–89%). An important demonstration of the protocol is the preparation of the unusual amino acid component of the bioactive cyclic peptide Chap-31.

Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy

2017 ◽  
Vol 25 (15) ◽  
pp. 4100-4109 ◽  
Author(s):  
Zigao Yuan ◽  
Shaopeng Chen ◽  
Qinsheng Sun ◽  
Ning Wang ◽  
Dan Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Hydroxamic Acid ◽  
Hdac Inhibitors ◽  
Hydroxamic Acid Derivatives

Novel α,β-unsaturated hydroxamic acid derivatives overcome cisplatin resistance

2019 ◽  
Vol 27 (19) ◽  
pp. 115036 ◽  
Author(s):  
Marc Pflieger ◽  
Alexandra Hamacher ◽  
Taner Öz ◽  
Nadine Horstick-Muche ◽  
Benedikt Boesen ◽  
...  
Keyword(s):  
Hydroxamic Acid ◽  
Cisplatin Resistance ◽  
Hydroxamic Acid Derivatives
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