scholarly journals Hydrolytic (In)stability of Methacrylate Esters in Covalently Cross-Linked Hydrogels Based on Chondroitin Sulfate and Hyaluronic Acid Methacrylate

ACS Omega ◽  
2021 ◽  
Author(s):  
Carl C. L. Schuurmans ◽  
Arwin J. Brouwer ◽  
Jacobus A. W. Jong ◽  
Geert-Jan P. H. Boons ◽  
Wim E. Hennink ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate

Glycosaminoglycans from growing antlers of wapiti (Cervus elaphus)

1997 ◽  
Vol 77 (4) ◽  
pp. 715-721 ◽  
Author(s):  
H. H. Sunwoo ◽  
L. Y. M. Sim ◽  
T. Nakano ◽  
R. J. Hudson ◽  
J. S. Sim
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Cervus Elaphus ◽  
Molecular Size ◽  
Enzymatic Digestion ◽  
Gel Chromatography ◽  
Cellulose Acetate Electrophoresis ◽  
Cartilaginous Tissues ◽  
Chondroitin Sulfates ◽  
Velvet Antler

The emerging wapiti industry in North America is based largely on markets for velvet antlers which are used in oriental medicine. Despite the economic opportunity, enthusiasm has been dampened by incomplete understanding of the chemical and pharmacological properties of velvet antler. This study characterizes polysaccharide constituents of glycosaminoglycans in growing antler of wapiti (Cervus elaphus). Glycosaminoglycans were isolated from four sections (tip, upper, middle and base) of growing antlers, and were studied using cellulose acetate electrophoresis, gel electrophoresis, enzymatic digestion and gel chromatography. The tip and upper sections of the antler which are rich in cartilaginous tissues contained chondroitin sulfate as a major glycosaminoglycan with small amounts of hyaluronic acid. In the middle and base sections containing bone and bone marrow, chondroitin sulfate was also a major glycosaminoglycan with small amounts of hyaluronic acid and chondroitinase-ACI resistant materials. More than half of chondroitin sulfate from the middle and base sections had larger molecular size than did the chondroitin sulfates from the tip and upper sections. Key words: Glycosaminoglycans, chondroitin sulfate, antler, wapiti

PO-01-112 Hyaluronic acid and chondroitin sulfate, alone or in combination, efficiently counteract induced bladder cells damage and inflammation

2019 ◽  
Vol 16 (5) ◽  
pp. S75-S76
Author(s):  
C. Schiraldi ◽  
A. Stellavato ◽  
A. V. Adriana Pirozzi ◽  
P. Diana ◽  
G. Donnarumma ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Bladder Cells

scholarly journals Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 325 ◽  
Author(s):  
Angela Faccendini ◽  
Marco Ruggeri ◽  
Dalila Miele ◽  
Silvia Rossi ◽  
Maria Cristina Bonferoni ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Drug Loading ◽  
Healing Process ◽  
Antimicrobial Properties ◽  
Resistance Mechanisms ◽  
Free Drug ◽  
Mechanical Resistance ◽  
Fibroblast Proliferation ◽  
Electrospun Scaffolds

Infections in nonhealing wounds remain one of the major challenges. Recently, nanomedicine approach seems a valid option to overcome the antibiotic resistance mechanisms. The aim of this study was the development of three types of polysaccharide-based scaffolds (chitosan-based (CH), chitosan/chondroitin sulfate-based (CH/CS), chitosan/hyaluronic acid-based (CH/HA)), as dermal substitutes, to be loaded with norfloxacin, intended for the treatment of infected wounds. The scaffolds have been loaded with norfloxacin as a free drug (N scaffolds) or in montmorillonite nanocomposite (H—hybrid-scaffolds). Chitosan/glycosaminoglycan (chondroitin sulfate or hyaluronic acid) scaffolds were prepared by means of electrospinning with a simple, one-step process. The scaffolds were characterized by 500 nm diameter fibers with homogeneous structures when norfloxacin was loaded as a free drug. On the contrary, the presence of nanocomposite caused a certain degree of surface roughness, with fibers having 1000 nm diameters. The presence of norfloxacin–montmorillonite nanocomposite (1%) caused higher deformability (90–120%) and lower elasticity (5–10 mN/cm2), decreasing the mechanical resistance of the systems. All the scaffolds were proven to be degraded via lysozyme (this should ensure scaffold resorption) and this sustained the drug release (from 50% to 100% in 3 days, depending on system composition), especially when the drug was loaded in the scaffolds as a nanocomposite. Moreover, the scaffolds were able to decrease the bioburden at least 100-fold, proving that drug loading in the scaffolds did not impair the antimicrobial activity of norfloxacin. Chondroitin sulfate and montmorillonite in the scaffolds are proven to possess a synergic performance, enhancing the fibroblast proliferation without impairing norfloxacin’s antimicrobial properties. The scaffold based on chondroitin sulfate, containing 1% norfloxacin in the nanocomposite, demonstrated adequate stiffness to sustain fibroblast proliferation and the capability to sustain antimicrobial properties to prevent/treat nonhealing wound infection during the healing process.

scholarly journals The effect of gelatin–chondroitin sulfate–hyaluronic acid skin substitute on wound healing in SCID mice

Biomaterials ◽  
2006 ◽  
Vol 27 (33) ◽  
pp. 5689-5697 ◽  
Author(s):  
Tzu-Wei Wang ◽  
Jui-Sheng Sun ◽  
Hsi-Chin Wu ◽  
Yang-Hwei Tsuang ◽  
Wen-Hsi Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Scid Mice ◽  
Skin Substitute
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