scholarly journals Structure-Based Epitope Design: Toward a Greater Antibody–SARS-CoV-2 RBD Affinity

ACS Omega ◽  
2021 ◽  
Author(s):  
Hassan Traboulsi ◽  
Mohammed A. Khedr ◽  
Yasair S. S. Al-Faiyz ◽  
Rafea Elgorashe ◽  
Amr Negm
Keyword(s):  
Epitope Design

scholarly journals Short peptide epitope design from hantaviruses causing HFRS

2017 ◽  
Vol 13 (07) ◽  
pp. 231-236 ◽  
Author(s):  
Sathish Sankar ◽  
◽  
Mageshbabu Ramamurthy ◽  
Balaji Nandagopal ◽  
Gopalan Sridharan ◽  
...  
Keyword(s):  
Peptide Epitope ◽  
Short Peptide ◽  
Epitope Design

Recent Advances in Epitope Design for Immunotherapy of Cancer

2009 ◽  
Vol 4 (3) ◽  
pp. 227-240 ◽  
Author(s):  
Pieranna Chiarella ◽  
Emanuela Massi ◽  
Mariangela De Robertis ◽  
Vito Fazio ◽  
Emanuela Signori
Keyword(s):  
Recent Advances ◽  
Immunotherapy Of Cancer ◽  
Epitope Design

Epitope Design from Transporter Targets in N. gonorrhoeae

2009 ◽  
Vol 02 (11) ◽  
pp. 475-480 ◽  
Author(s):  
Debmalya Barh ◽  
Amarendra Narayana Misra
Keyword(s):  
Epitope Design

scholarly journals Epitope design of L1 protein for vaccine production against Human Papilloma Virus types 16 and 18

2017 ◽  
Vol 13 (03) ◽  
pp. 86-93 ◽  
Author(s):  
Sunanda Baidya ◽  
◽  
Rasel Das ◽  
Md. Golam Kabir ◽  
Md. Arifuzzaman ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Vaccine Production ◽  
Papilloma Virus ◽  
L1 Protein ◽  
Epitope Design

scholarly journals Peptide-based epitope design on non-structural proteins of SARS-CoV-2

2021 ◽  
Author(s):  
Swathika RS ◽  
Vimal S ◽  
Bhagya Shree E ◽  
Elakkiya Elumalai ◽  
Krishna Kant Gupta
Keyword(s):  
Low Cost ◽  
Protein Sequences ◽  
Surface Glycoprotein ◽  
Structural Proteins ◽  
T Cell Epitopes ◽  
Future Studies ◽  
Online Tools ◽  
Leader Protein ◽  
Allele Drb1 ◽  
Epitope Design

The SARS-CoV-2 virus has caused the severe pandemic, COVID19 and since then its been critical to produce a potent vaccine to prevent the quick transmission and also to avoid alarming deaths. Among all type of vaccines peptide based epitope design tend to outshine with respect to low cost production and more efficacy. Therefore, we started with obtaining the necessary protein sequences from NCBI database of SARS-CoV-2 virus and filtered with respect to antigenicity, virulency, pathogenicity and non- homologous nature with human proteome using different available online tools and servers. The promising proteins was checked for containing common B and T- cell epitopes. The structure for these proteins were modeled from I-TASSER server followed by its refinement and validation. The predicted common epitopes were mapped on modeled structures of proteins by using Pepitope server. The surface exposed epitopes were docked with the most common allele DRB1*0101 using the GalaxyPepDock server. The epitopes, ELEGIQYGRS from Leader protein (NSP1), YGPFVDRQTA from 3c-like proteinase (nsp5), DLKWARFPKS from NSP9 and YQDVNCTEVP from Surface glycoprotein (spike protein) are the epitopes which has more hydrogen bonds. Hence these four epitopes could be considered as a more promising epitopes and these epitopes can be used for future studies.

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