scholarly journals Aggregation of Lysozyme in the Presence of a Mixed Bilayer of POPC and POPG

ACS Omega ◽  
2021 ◽  
Author(s):  
Shahee Islam ◽  
Chaitali Mukhopadhyay
Keyword(s):  
Mixed Bilayer

Interactions of the Antimicrobial Peptide Maculatin 1.1 and Analogues with Phospholipid Bilayers

2011 ◽  
Vol 64 (6) ◽  
pp. 798 ◽  
Author(s):  
David I. Fernandez ◽  
Marc-Antoine Sani ◽  
Frances Separovic
Keyword(s):  
Antimicrobial Peptide ◽  
Solid State Nmr ◽  
Acyl Chain ◽  
Head Group ◽  
Group Interactions ◽  
Bacterial Membranes ◽  
Helical Content ◽  
Lipid System ◽  
Acyl Chains ◽  
Mixed Bilayer

The interactions of the antimicrobial peptide, maculatin 1.1 (GLFGVLAKVAAHVVPAIAEHF-NH2) and two analogues, with model phospholipid membranes have been studied using solid-state NMR and circular dichroism spectroscopy. Maculatin 1.1 and the P15G and P15A analogues displayed minimal secondary structure in water, but with zwitterionic dimyristoylphosphatidylcholine (DMPC) vesicles displayed a significant increase in α-helical content. In mixed phospholipid vesicles of DMPC and anionic dimyristoylphosphatidylglycerol (DMPG), each peptide was highly structured with ~80% α-helical content. In DMPC vesicles, the native peptide displayed moderate head group interaction and significant perturbation of the lipid acyl chains. In DMPC/DMPG vesicles, maculatin 1.1 promoted formation of a DMPG-enriched phase and moderately increased disorder towards acyl chain ends of DMPC in the mixed bilayer. Both analogues showed reduced phospholipid head group interactions with DMPC but displayed significant interactions with the mixed lipid system. These effects support the preferential activity of these antimicrobial peptides for bacterial membranes.

scholarly journals Charge-reversal instability in mixed bilayer vesicles

2000 ◽  
Vol 62 (2) ◽  
pp. 2608-2619 ◽  
Author(s):  
Yi Chen ◽  
Philip Nelson
Keyword(s):  
Charge Reversal ◽  
Mixed Bilayer

scholarly journals Hydrophobic Biomimetic Nanoparticles drives Size-dependent Remodelling in Asymmetric Bilayers

2020 ◽  
Author(s):  
Sang Noh ◽  
Rebecca Notman
Keyword(s):  
Membrane Structure ◽  
Phase Interface ◽  
Line Tension ◽  
Size Dependent ◽  
Membrane Fission ◽  
Micelle Structure ◽  
Two Component ◽  
Biomimetic Nanoparticles ◽  
The Subject ◽  
Mixed Bilayer

The interactions between heterogeneous components in a biomimetic bilayer can control its physical properties such as its rigidity, local and bulk curvature and propensity towards phenomena such as membrane fission and fusion. In particular, nanoparticles (NPs) have been subjects of intense interest due to their similar scale to the bilayer width and its ability to affect local membrane structure. Generally, it is understood that hydrophobic components are energetically favoured to adsorb within the hydrophobic interior of a biomimetic bilayer. However, how such NPs interact in the presence of heterogeneous aggregates in the bilayer has been the subject of much debate. To better understand the effects of the integration of nanoscale components on heterogeneous mixed bilayer, we have simulated a series of generic hydrophobic NPs interacting with a phase-separating two-component surfactant bilayer. We find that the hydrophobic NP tends to aggregate at the phase interface, acting as a line tension relaxant i.e. a lineactant on the phase separated interface, which results in a variety of demixing behavior. We demonstrate that depending on the size of the NP, the localized softening of surfactants and the formation of a mixing gradient of surfactants can drive the a cap/bud formation around the NP, as well as the formation of a NP-micelle structure<br>

scholarly journals Budding of domains in mixed bilayer membranes

2015 ◽  
Vol 91 (1) ◽  
Author(s):  
Jean Wolff ◽  
Shigeyuki Komura ◽  
David Andelman
Keyword(s):  
Bilayer Membranes ◽  
Mixed Bilayer

scholarly journals Flip-Flop Motions of Lipid Molecules in Mixed Bilayer Systems

2010 ◽  
Vol 98 (3) ◽  
pp. 489a ◽  
Author(s):  
Fumiko Ogushi ◽  
Reiko Ishitsuka ◽  
Toshihide Kobayashi ◽  
Yuji Sugita
Keyword(s):  
Flip Flop ◽  
Mixed Bilayer

scholarly journals In-plane miscibility and mixed bilayer microstructure in mixtures of catanionic glycolipids and zwitterionic phospholipids

2006 ◽  
Vol 1758 (11) ◽  
pp. 1797-1808 ◽  
Author(s):  
C.V. Teixeira ◽  
M. Blanzat ◽  
J. Koetz ◽  
I. Rico-Lattes ◽  
G. Brezesinski
Keyword(s):  
Mixed Bilayer
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