scholarly journals Time-Dependent Analysis of Paenarthrobacter nicotinovorans pAO1 Nicotine-Related Proteome

ACS Omega ◽  
2021 ◽  
Author(s):  
Marius Mihăşan ◽  
Răzvan Ştefan Boiangiu ◽  
Doina Guzun ◽  
Cornelia Babii ◽  
Roshanak Aslebagh ◽  
...  
Keyword(s):  
Time Dependent ◽  
Time Dependent Analysis

Applications of Time-Dependent Analysis in the Design of Hybrid Bridge Structures

PCI Journal ◽  
2001 ◽  
Vol 46 (4) ◽  
pp. 56-74 ◽  
Author(s):  
Jiri Strasky ◽  
Jaroslav Navratil ◽  
Stanislav Susky
Keyword(s):  
Time Dependent ◽  
Hybrid Bridge ◽  
Bridge Structures ◽  
Time Dependent Analysis

scholarly journals The time-dependent angular analysis of Bd → KSℓℓ, a new benchmark for new physics

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Sébastien Descotes-Genon ◽  
Martín Novoa-Brunet ◽  
K. Keri Vos
Keyword(s):  
Time Evolution ◽  
Form Factors ◽  
New Physics ◽  
Time Dependent ◽  
Angular Analysis ◽  
Time Dependent Analysis ◽  
Tensor Operators

Abstract We consider the time-dependent analysis of Bd→ KSℓℓ taking into account the time-evolution of the Bd meson and its mixing into $$ {\overline{B}}_d $$ B ¯ d . We discuss the angular conventions required to define the angular observables in a transparent way with respect to CP conjugation. The inclusion of time evolution allows us to identify six new observables, out of which three could be accessed from a time-dependent tagged analysis. We also show that these observables could be obtained by time-integrated measurements in a hadronic environment if flavour tagging is available. We provide simple and precise predictions for these observables in the SM and in NP models with real contributions to SM and chirally flipped operators, which are independent of form factors and charm-loop contributions. As such, these observables provide robust and powerful cross-checks of the New Physics scenarios currently favoured by global fits to b → sℓℓ data. In addition, we discuss the sensitivity of these observables with respect to NP scenarios involving scalar and tensor operators, or CP-violating phases. We illustrate how these new observables can provide a benchmark to discriminate among the various NP scenarios in b → sμμ. We discuss the extension of these results for Bs decays into f0, η or η′.

scholarly journals General Anaesthesia Shifts the Murine Circadian Clock in a Time-Dependant Fashion

2021 ◽  
Vol 3 (1) ◽  
pp. 87-97
Author(s):  
Nicola M. Ludin ◽  
Alma Orts-Sebastian ◽  
James F. Cheeseman ◽  
Janelle Chong ◽  
Alan F. Merry ◽  
...  
Keyword(s):  
Circadian Clock ◽  
General Anaesthesia ◽  
Wheel Running ◽  
Phase Shifts ◽  
Time Dependent ◽  
Suprachiasmatic Nuclei ◽  
Response Curves ◽  
Inhalational Anaesthetic ◽  
Locomotor Rhythms ◽  
Time Dependent Analysis

Following general anaesthesia (GA), patients frequently experience sleep disruption and fatigue, which has been hypothesized to result at least in part by GA affecting the circadian clock. Here, we provide the first comprehensive time-dependent analysis of the effects of the commonly administered inhalational anaesthetic, isoflurane, on the murine circadian clock, by analysing its effects on (a) behavioural locomotor rhythms and (b) PER2::LUC expression in the suprachiasmatic nuclei (SCN) of the mouse brain. Behavioural phase shifts elicited by exposure of mice (n = 80) to six hours of GA (2% isoflurane) were determined by recording wheel-running rhythms in constant conditions (DD). Phase shifts in PER2::LUC expression were determined by recording bioluminescence in organotypic SCN slices (n = 38) prior to and following GA exposure (2% isoflurane). Full phase response curves for the effects of GA on behaviour and PER2::LUC rhythms were constructed, which show that the effects of GA are highly time-dependent. Shifts in SCN PER2 expression were much larger than those of behaviour (c. 0.7 h behaviour vs. 7.5 h PER2::LUC). We discuss the implications of this work for understanding how GA affects the clock, and how it may inform the development of chronotherapeutic strategies to reduce GA-induced phase-shifting in patients.

Two‐dimensional time‐dependent analysis of the switching of a thyristor

1977 ◽  
Vol 48 (1) ◽  
pp. 270-278 ◽  
Author(s):  
Shih‐Pei Hu ◽  
Benjamin M. Rabinovici
Keyword(s):  
Time Dependent ◽  
Two Dimensional ◽  
Time Dependent Analysis

scholarly journals Neuraminidase inhibitors, superinfection and corticosteroids affect survival of influenza patients

2015 ◽  
Vol 45 (6) ◽  
pp. 1642-1652 ◽  
Author(s):  
Nelson Lee ◽  
Yee-Sin Leo ◽  
Bin Cao ◽  
Paul K.S. Chan ◽  
W.M. Kyaw ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Cox Regression ◽  
Management Strategies ◽  
Patient Characteristics ◽  
Primary Outcome Measure ◽  
Time Dependent ◽  
High Morbidity ◽  
Neuraminidase Inhibitors ◽  
Systemic Corticosteroids ◽  
Time Dependent Analysis

We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic influenza. Individual-patient data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed influenza (prospectively diagnosed) during 2008–2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used.Patients had high morbidity (respiratory/nonrespiratory complications in 68.4%, respiratory failure in 48.6%, pneumonia in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30 days and 6.9% at 60 days). 75.2% received neuraminidase inhibitors (NAI) (73.8% received oseltamivir and 1.4% received peramivir/zanamivir; 44.5% of patients received NAI ≤2 days and 65.5% ≤5 days after onset of illness); 23.1% received systemic corticosteroids. There were fewer deaths among NAI-treated patients (5.3% versus 7.6%; p=0.032). NAI treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19–0.43), adjusted for treatment-propensity score and patient characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52–3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23–0.84) death risks. Best survival was shown when treatment started within ≤2 days (adjusted HR 0.20, 95% CI 0.12–0.32), but there was benefit with treatment within 3–5 days (adjusted HR 0.35, 95% CI 0.21–0.58). Time-dependent analysis showed consistent results of NAI treatment (adjusted HR 0.39, 95% CI 0.27–0.57). Corticosteroids increased superinfection (9.7% versus 2.7%) and deaths when controlled for indications (adjusted HR 1.73, 95% CI 1.14–2.62). Early NAI treatment was associated with shorter length of stay in a subanalysis.NAI treatment may improve survival of hospitalised influenza patients; benefit is greatest from, but not limited to, treatment started within 2 days of illness. Superinfections and corticosteroids increase mortality. Antiviral and non-antiviral management strategies should be considered.

Time dependent analysis of finite buffer fluid flows and risk models with a dividend barrier

2007 ◽  
Vol 55 (4) ◽  
pp. 207-222 ◽  
Author(s):  
Soohan Ahn ◽  
Andrei L. Badescu ◽  
V. Ramaswami
Keyword(s):  
Fluid Flows ◽  
Time Dependent ◽  
Finite Buffer ◽  
Risk Models ◽  
Time Dependent Analysis
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