scholarly journals A Cyclic Dipeptide from Marine Fungus Penicillium chrysogenum DXY-1 Exhibits Anti-quorum Sensing Activity

ACS Omega ◽  
2021 ◽  
Vol 6 (11) ◽  
pp. 7693-7700 ◽  
Author(s):  
Xiaodan Yu ◽  
Li Li ◽  
Shiwei Sun ◽  
Aiping Chang ◽  
Xiaoyun Dai ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Penicillium Chrysogenum ◽  
Marine Fungus ◽  
Cyclic Dipeptide

scholarly journals Cladodionen Is a Potential Quorum Sensing Inhibitor Against Pseudomonas aeruginosa

Marine Drugs ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 205 ◽  
Author(s):  
Mengjia Wang ◽  
Lu Zhao ◽  
Hao Wu ◽  
Chaoyue Zhao ◽  
Qianhong Gong ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Binding Affinity ◽  
Virulence Factors ◽  
Jiaozhou Bay ◽  
Opportunistic Pathogen ◽  
Inhibitory Effect ◽  
Marine Fungus ◽  
Docking Analysis ◽  
Novel Approach

Pseudomonas aeruginosa is an opportunistic pathogen using virulence factors and biofilm regulated by quorum sensing (QS) systems to infect patients and protect itself from environmental stress and antibiotics. Interfering with QS systems is a novel approach to combat P. aeruginosa infections without killing the bacteria, meaning that it is much harder for bacteria to develop drug resistance. A marine fungus Cladosporium sp. Z148 with anti-QS activity was obtained from Jiaozhou Bay, China. Cladodionen, a novel QS inhibitor, was isolated from the extracts of this fungus. Cladodionen had a better inhibitory effect than pyocyanin on the production of elastase and rhamnolipid. It also inhibited biofilm formation and motilities. The mRNA expressions of QS-related genes, including receptor proteins (lasR, rhlR and pqsR), autoinducer synthases (lasI, rhlI and pqsA) and virulence factors (lasB and rhlA) were down-regulated by cladodionen. Molecular docking analysis showed that cladodionen had better binding affinity to LasR and PqsR than natural ligands. Moreover, the binding affinity of cladodionen to LasR was higher than to PqsR. Cladodionen exhibits potential as a QS inhibitor against P. aeruginosa, and its structure–activity relationships should be further studied to illustrate the mode of action, optimize its structure and improve anti-QS activity.

Exploring the quorum sensing inhibition of isolated chrysin from Penicillium chrysogenum DXY-1

2021 ◽  
Vol 111 ◽  
pp. 104894
Author(s):  
Aiping Chang ◽  
Qiaomei He ◽  
Li Li ◽  
Xiaodan Yu ◽  
Shiwei Sun ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Penicillium Chrysogenum ◽  
Quorum Sensing Inhibition

Secondary Metabolites of the Marine Fungus Penicillium chrysogenum

2014 ◽  
Vol 50 (3) ◽  
pp. 405-407 ◽  
Author(s):  
Jingjing Wang ◽  
Yunli Zhao ◽  
Lei Men ◽  
Yixuan Zhang ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Penicillium Chrysogenum ◽  
Marine Fungus

scholarly journals Stereochemical Investigation of a Novel Biological Active Substance from the Secondary Metabolites of Marine Fungus Penicillium chrysogenum SYP-F-2720

2017 ◽  
Vol 59 (1) ◽  
Author(s):  
Tiemin Sun
Keyword(s):  
Secondary Metabolites ◽  
Quantum Chemical ◽  
Penicillium Chrysogenum ◽  
Chemical Structure ◽  
Marine Fungus ◽  
Raw Material ◽  
Target Compound ◽  
Synthetic Compound ◽  
Ulcerogenic Effect ◽  
Analgesic Activities

<p>The chemical structure and absolute configuration of a<br />novel benzoic acid (1) which is the secondary metabolites from the<br />marine fungus Penicillium chrysogenum SYP-F-2720, has been determined<br />by experimental spectroscopic data and quantum chemical<br />calculations of its electronic circular dichroism (ECD). The configurational<br />assignments were further confirmed by the highly consistent<br />spectra between natural compound and synthetic compound which<br />from raw material with a definite configuration. Furthermore, The<br />target compound exhibited more significant anti-inflammatory and<br />analgesic activities than aspirin when administered at 100 mg/kg,<br />however, it behaved no ulcerogenic effect.</p>

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