scholarly journals Folate Receptors’ Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities

ACS Omega ◽  
2021 ◽  
Vol 6 (6) ◽  
pp. 4111-4118
Author(s):  
Eva McCord ◽  
Shreya Pawar ◽  
Tejaswi Koneru ◽  
Katyayani Tatiparti ◽  
Samaresh Sau ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folate Receptors

Rapidly cell-penetrating and reductive milieu-responsive nanoaggregates assembled from an amphiphilic folate-camptothecin prodrug for enhanced drug delivery and controlled release

2017 ◽  
Vol 5 (3) ◽  
pp. 444-454 ◽  
Author(s):  
Zhigang Xu ◽  
Meili Hou ◽  
Xiaoxiao Shi ◽  
Yong-E. Gao ◽  
Peng Xue ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Folate Receptors ◽  
Tumour Detection ◽  
Cell Penetrating ◽  
Self Assembled

Self-assembled small molecular prodrug loaded with camptothecin in response to glutathione and folate receptors for combined tumour detection and treatment.

Folate-conjugated nanodiamond for tumor-targeted drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (101) ◽  
pp. 82711-82716 ◽  
Author(s):  
Yu Dong ◽  
Ruixia Cao ◽  
Yingqi Li ◽  
Zhiqin Wang ◽  
Lin Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Normal Cells ◽  
Folate Receptors ◽  
Receptor Mediated Endocytosis ◽  
Targeted Drug

Relying on the role of folate and folate receptors, NPFD nanoparticles tend to selectively discriminate tumor cells from normal cells and enter the cells by clathrin-dependent and receptor-mediated endocytosis.

Targeted drug delivery via folate receptors

2008 ◽  
Vol 5 (3) ◽  
pp. 309-319 ◽  
Author(s):  
Xiaobin Zhao ◽  
Hong Li ◽  
Robert J Lee
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Folate Receptors ◽  
Targeted Drug

scholarly journals Multifunctional Cholesterol-modified Dendrimers for Targeted Drug Delivery to Cancer Cells Expressing Folate Receptors

2018 ◽  
Vol 37 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Fan-Fan Fu ◽  
Ben-Qing Zhou ◽  
Zhi-Jun Ouyang ◽  
Yi-Lun Wu ◽  
Jing-Yi Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Folate Receptors ◽  
Targeted Drug

scholarly journals A Novel Method of Magnetic Nanoparticles Functionalized with Anti-Folate Receptor Antibody and Methotrexate for Antibody Mediated Targeted Drug Delivery

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 261
Author(s):  
Madeeha Shahzad Lodhi ◽  
Fatima Khalid ◽  
Muhammad Tahir Khan ◽  
Zahoor Qadir Samra ◽  
Shabbir Muhammad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Folate Receptor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Folate Receptors ◽  
Receptor Antibody ◽  
Targeted Drug

Therapeutic effects of anticancer medicines can be improved by targeting the specific receptors on cancer cells. Folate receptor (FR) targeting with antibody (Ab) is an effective tool to deliver anticancer drugs to the cancer cell. In this research project, a novel formulation of targeting drug delivery was designed, and its anticancer effects were analyzed. Folic acid-conjugated magnetic nanoparticles (MNPs) were used for the purification of folate receptors through a novel magnetic affinity purification method. Antibodies against the folate receptors and methotrexate (MTX) were developed and characterized with enzyme-linked immunosorbent assay and Western blot. Targeting nanomedicines (MNP-MTX-FR Ab) were synthesized by engineering the MNP with methotrexate and anti-folate receptor antibody (anti-FR Ab). The cytotoxicity of nanomedicines on HeLa cells was analyzed by calculating the % age cell viability. A fluorescent study was performed with HeLa cells and tumor tissue sections to analyze the binding efficacy and intracellular tracking of synthesized nanomedicines. MNP-MTX-FR Ab demonstrated good cytotoxicity along all the nanocomposites, which confirms that the antibody-coated medicine possesses the potential affinity to destroy cancer cells in the targeted drug delivery process. Immunohistochemical approaches and fluorescent study further confirmed their uptake by FRs on the tumor cells’ surface in antibody-mediated endocytosis. The current approach is a useful addition to targeted drug delivery for better management of cancer therapy along with immunotherapy in the future.

Targeted Drug Delivery via Folate Receptors for the Treatment of Brain Cancer: Can the Promise Deliver?

2017 ◽  
Vol 106 (12) ◽  
pp. 3413-3420 ◽  
Author(s):  
Jianfeng Guo ◽  
Michele Schlich ◽  
John F. Cryan ◽  
Caitriona M. O'Driscoll
Keyword(s):  
Drug Delivery ◽  
Brain Cancer ◽  
Targeted Drug Delivery ◽  
Folate Receptors ◽  
Targeted Drug

scholarly journals Targeted drug delivery via folate receptors in recurrent ovarian cancer: a review

2014 ◽  
pp. 1223 ◽  
Author(s):  
Claudia Marchetti ◽  
Margherita Giorgini ◽  
Caterina De Medici ◽  
Innocenza Palaia ◽  
Roberta Iadarola ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Recurrent Ovarian Cancer ◽  
Folate Receptors ◽  
Targeted Drug

scholarly journals Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

2020 ◽  
Author(s):  
Monika Ruzycka ◽  
Patrycja Kowalik ◽  
Agata Kowalczyk ◽  
Piotr Bujak ◽  
Anna M. Nowicka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Dna Breaks ◽  
Folate Receptors

Abstract Background Lung cancer is one of the most frequently diagnosed cancer all over the world and a leading cancer-related mortality. The therapy of lung cancer includes surgery, chemotherapy and radiatherapy and mailny depends on the type and stage of lung cancer characterized based on WHO guidelines. Althought the conventional chemotherapy is the main treatment option for small cell lung cancer (SCLC) and a common treatment for non-SCLC it is characterized with lack of specificity resulting to severe toxicities of normal cells and harmful side effects. Therefore, targeted drug delivery (TDD) systems have been used to reduce the systemic toxicity of some conventional chemotherapies in lung cancer. Quantum dots (QDs) are fascinating nanoscale crystals that can serve as nanocarriers in TDD due to their unique physicochemical properties. Therefore, in this paper, the as-desiged QDs, Ag-In-Zn-S-based nanoconjugates for selective doxorubicin (DOX) targeting to lung cancer cells were developed. The QD nanocrystals were modified with 11-mercaptoundecanoic acid (MUA), L-cysteine (Cys) and lipoic acid (LA) used as drug carriers for targeted delivery of DOX to A549 cells through conjugated folic acid (FA) a self-navigation molecule that docks to the folate receptors on cancer cells. The comprechensive physicochemical, cytotoxicity and genotoxicity studies were performed to characterise the novel QD-based nanocaries and their anticancer cargos. Results The results from FTIR, DLS and fluorescence quenching evidenced the successful attachment of FA to the QDs nanocrystals and DOX to the QDs-FA nanocarriers. UV-vis analysis determined the amount of FA and DOX covalently anchored to the QDs nanocrystal surface. Biological screeining revealed that QDs-FA-DOX nanoconjugates showed higher cytotoxicity in comparison to other forms of the synthesized QD samples, suggesting the cytotoxic effect of liberated DOX from the QD constructs. QD-MUA-FA-DOX occurred to be the most cytotoxic against A549 cells among nanoconjugates. In vitro scratch assay also revealed significant inhibition of A549 migration only due to treatment with QD-MUA-FA-DOX. Studies evidenced that all the nanoconjugates at IC 50 induced significantly more DNA breaks than that observed in non-treated cells. All in all, significant and the greatest cytotoxicity, genotoxicity together with inhibition of migratory potential of A549 cells was observed for QD-MUA-FA-DOX. Conclusion The studies show the therapeutic efficacy of DOX-loaded QD-based cargos suggesting their promising role as novel drug delivery systems navigating to folate receptors in lung cancer cells.

scholarly journals Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors

2017 ◽  
Vol Volume 11 ◽  
pp. 1315-1334 ◽  
Author(s):  
Tatiana Slastnikova ◽  
Andrey Rosenkranz ◽  
Yuri Khramtsov ◽  
Tatiana Karyagina ◽  
Sergey Ovechko ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folate Receptors
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