scholarly journals Naringin in Combination with Isothiocyanates as Liposomal Formulations Potentiates the Anti-inflammatory Activity in Different Acute and Chronic Animal Models of Rheumatoid Arthritis

ACS Omega ◽  
2020 ◽  
Vol 5 (43) ◽  
pp. 28319-28332
Author(s):  
Sangeeta Mohanty ◽  
Ashish Kumar Sahoo ◽  
V. Badireenath Konkimalla ◽  
Abhisek Pal ◽  
Sudam Chandra Si
Keyword(s):  
Rheumatoid Arthritis ◽  
Animal Models ◽  
Inflammatory Activity ◽  
Liposomal Formulations ◽  
Anti Inflammatory

Evaluation of the Anti-inflammatory Activity of Luteolin in Experimental Animal Models

Planta Medica ◽  
2007 ◽  
Vol 73 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Li Ziyan ◽  
Zhou Yongmei ◽  
Zhang Nan ◽  
Tang Ning ◽  
Liu Baolin
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Inflammatory Activity ◽  
Experimental Animal Models ◽  
Anti Inflammatory

scholarly journals Animal Models as Tools to Investigate Antidiabetic and Anti-Inflammatory Plants

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Mohamed Eddouks ◽  
Debprasad Chattopadhyay ◽  
Naoufel Ali Zeggwagh
Keyword(s):  
Animal Models ◽  
Public Health Problem ◽  
New Drugs ◽  
Inflammatory Activity ◽  
Global Public Health ◽  
Plant Materials ◽  
Inflammatory Mechanism ◽  
Anti Inflammatory ◽  
Materials Used

Plants have been historically used for diabetes treatment and related anti-inflammatory activity throughout the world; few of them have been validated by scientific criteria. Recently, a large diversity of animal models has been developed for better understanding the pathogenesis of diabetes mellitus and its underlying inflammatory mechanism and new drugs have been introduced in the market to treat this disease. The aim of this work is to review the available animal models of diabetes and anti-inflammatory activity along with somein vitromodels which have been used as tools to investigate the mechanism of action of drugs with potential antidiabetic properties and related anti-inflammatory mechanism. At present, the rigorous procedures for evaluation of conventional antidiabetic medicines have rarely been applied to test raw plant materials used as traditional treatments for diabetes; and natural products, mainly derived from plants, have been tested in chemically induced diabetes model. This paper contributes to design new strategies for the development of novel antidiabetic drugs and its related inflammatory activity in order to treat this serious condition which represents a global public health problem.

scholarly journals Activity of Tokulo (Kleinhovia hospita L.) as Anti Rheumatoid Arthritis and Anti-inflammatory in White Rats Induced by Complete Freud Adjuvant (CFA)

2021 ◽  
Vol 5 (3) ◽  
pp. 233-238
Author(s):  
Fatma Sari Siharis ◽  
Selpirahmawati Saranani ◽  
Nurlansi Nurlansi
Keyword(s):  
Rheumatoid Arthritis ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
White Rats ◽  
Nsaid Group ◽  
Anti Inflammatory

Tokulo (Kleinhovia hospita) leaves are commonly used by Moronene people (Southeast Sulawesi) to treat headaches. This is supported scientifically from research which states that tokulo leaves have analgesic and anti-inflammatory activity. The NSAID group is included in the anti-rheumatoid arthritis therapy. To determine the anti-RA activity of this plant, a study was carried out on CFA-induced rats. Based on the results of the study, it is known that the ethanol extract of tokulo leaves has anti-RA and anti-inflammatory activity in CFA-induced rats. Keywords: Kleinhovia hospita, Rheumatoid Arthritis, Inflammation

scholarly journals ANTI-PYRETIC AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OFSOLANUM XANTHOCARPUM BERRIES IN SUITABLE ANIMAL MODELS

2021 ◽  
Vol 9 (11) ◽  
pp. 954-959
Author(s):  
Leisangthem Tarinita Devi ◽  
◽  
Mayanglambam Medhabati Devi ◽  
Florence Lalvarmawi ◽  
Swagata Datta ◽  
...  
Keyword(s):  
Animal Models ◽  
Aqueous Extract ◽  
Inflammatory Activity ◽  
Active Principle ◽  
Traditional Medicines ◽  
Control Drug ◽  
Paw Oedema ◽  
Study Results ◽  
Anti Inflammatory ◽  
Solanum Xanthocarpum

Background: Use of traditional medicines for treating various diseases have become a topic of global importance because of their safety, less side effects and cost-effectiveness. The present study was undertaken to evaluate the anti-pyretic and anti-inflammatory activity of aqueous extract of Solanum xanthocarpum berries (SXB) in suitable animal models. Methods: Anti-pyretic activity was assessed by dried yeast induced pyrexia in rats. Anti-inflammatory activity was evaluated using carrageenan induced paw oedema in rats. Three doses of the plant extract (500, 1000 and 1500 mg/kg) prepared by dissolving the drugs in 2% gum acacia were used. Paracetamol 33 mg/kg and aspirin 100 mg/kg were used as standard drugs for anti-pyretic and anti-inflammatory activity respectively. Vehicle served as a control drug. Results: Acute toxicity study results demonstrated no mortality of animals after 24 hours. The aqueous extract of the plant significantly decreased the rectal temperature of the rats and significantly prevented increase in volume of paw oedema. Conclusion: The aqueous extract of Solanum xanthocarpum berries exerts its anti-pyretic and anti-inflammatory activity activity. However, further studies with the plant are required to evaluate the dose dependent activity and also to determine the active principle responsible for exact mechanism for both antipyretic and anti-inflammatory activity.

scholarly journals Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-pregabalin in animal models of pain and inflammation

2017 ◽  
Vol 6 (6) ◽  
pp. 1511
Author(s):  
Suthakaran C. ◽  
Raja T. A. R. ◽  
Kayalvizhi M. K. ◽  
Nithya K. ◽  
Ramnarayana Reddy R. V.
Keyword(s):  
Acetic Acid ◽  
Reaction Time ◽  
Animal Models ◽  
Inflammatory Activity ◽  
Tail Flick ◽  
High Dose ◽  
Hot Plate ◽  
Provide Pain Relief ◽  
Anti Inflammatory ◽  
Rats And Mice

Background: A major goal of pain management is to provide pain relief that is clinically meaningful, sustained, and associated with minimum and reversible adverse effects. Since single analgesic drug is not effective in all patients, there is a need either to develop new and more effective drugs or to identify favourable combinations of drugs that are already available. The aim of the present was to evaluate the analgesic and anti-inflammatory activity of tramadol and pregabalin when used alone or in combination in animal models of pain and inflammation.Methods: The animals (rats and mice) were divided into eight groups with six animals in each group. Analgesia was assessed by acetic acid induced writhing and tail flick methods in mice and hot plate method in rats. Paw oedema model in rats after induction with 0.1 ml of 1% carrageenan was used to assess the anti‑inflammatory activity. The percentage inhibition of writhes and prolongation of reaction time were used for assessing analgesic activity and reduction in paw volume was used for assessing anti-inflammatory activity. The results obtained were analysed by ANOVA and Tukey HSD Post-hoc Test.Results: Treatment with tramadol pregabalin alone or in combination reduced writhing episodes significantly in acetic acid induced writhing in mice as compared to control indicating its analgesic effect and the highest percentage inhibition of pain was seen with high dose tramadol plus pregabalin. Treatment in Hot plate and Tail flick methods significantly prolonged the reaction time at all time points.Conclusions: Tramadol when combined with pregabalin may enhance its anti-nociceptive effects. If confirmed in additional models of acute and/or chronic pain this combination might be useful in the clinical management of pain not associated with inflammation.

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