scholarly journals A Customized Self-Assembling Peptide Hydrogel-Wrapped Stem Cell Factor Targeting Pulp Regeneration Rich in Vascular-Like Structures

ACS Omega ◽  
2020 ◽  
Vol 5 (27) ◽  
pp. 16568-16574
Author(s):  
Xiaodan Mu ◽  
Lei Shi ◽  
Shuang Pan ◽  
Lina He ◽  
Yumei Niu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Factor ◽  
Pulp Regeneration ◽  
Self Assembling ◽  
Peptide Hydrogel

Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration

2016 ◽  
Vol 12 (7) ◽  
pp. 2115-2125 ◽  
Author(s):  
Xiaoxiao Wang ◽  
Jinmei Wang ◽  
Ling Guo ◽  
Xusheng Wang ◽  
Haiyan Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hydrogel Scaffolds ◽  
Self Assembling ◽  
Peptide Hydrogel

PFS-Functionalized Self-Assembling Peptide Hydrogel for the Maintenance of Human Adipose Stem Cell In Vitro

2017 ◽  
Vol 7 (10) ◽  
pp. 943-951 ◽  
Author(s):  
Yingying Chen ◽  
Jiaju Lu ◽  
Bangrui Chen ◽  
Shuo Wang ◽  
Deepti Rana ◽  
...  
Keyword(s):  
Stem Cell ◽  
Adipose Stem Cell ◽  
Self Assembling ◽  
Human Adipose Stem Cell ◽  
Peptide Hydrogel

scholarly journals Effects of Stem Cell Factor on Cell Homing During Functional Pulp Regeneration in Human Immature Teeth

2017 ◽  
Vol 23 (3-4) ◽  
pp. 115-123 ◽  
Author(s):  
Nisarat Ruangsawasdi ◽  
Matthias Zehnder ◽  
Raphael Patcas ◽  
Chafik Ghayor ◽  
Barbara Siegenthaler ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Factor ◽  
Pulp Regeneration ◽  
Cell Homing ◽  
Immature Teeth

Stem Cell Factor

2002 ◽  
Vol 14 (2) ◽  
pp. 0052-0059 ◽  
Author(s):  
Susan Smith ◽  
Adrian Piliponsky ◽  
Mor-Li Hartman ◽  
Francesca Levi-Schaffer
Keyword(s):  
Stem Cell ◽  
Stem Cell Factor

Downregulation of c-kit (Stem Cell Factor Receptor) in Transformed Hematopoietic Precursor Cells by Stroma Cells

Blood ◽  
1999 ◽  
Vol 93 (2) ◽  
pp. 554-563 ◽  
Author(s):  
Christoph Heberlein ◽  
Jutta Friel ◽  
Christine Laker ◽  
Dorothee von Laer ◽  
Ulla Bergholz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Line ◽  
Stem Cell Factor ◽  
Progenitor Cell ◽  
Receptor Expression ◽  
General Mechanism ◽  
Ligand Interaction ◽  
Kit Ligand ◽  
Kit Receptor ◽  
Progenitor Cell Line

Abstract We show a dramatic downregulation of the stem cell factor (SCF) receptor in different hematopoietic cell lines by murine stroma. Growth of the human erythroid/macrophage progenitor cell line TF-1 is dependent on granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3). However, TF-1 cells clone and proliferate equally well on stroma. Independent stroma-dependent TF-1 clones (TF-1S) were generated on MS-5 stroma. Growth of TF-1S and TF-1 cells on stroma still requires interaction between c-kit (SCF receptor) and its ligand SCF, because antibodies against c-kit inhibit growth to less than 2%. Surprisingly, c-kit receptor expression (RNA and protein) was downregulated by 2 to 3 orders of magnitude in TF-1S and TF-1 cells grown on stroma. This stroma-dependent regulation of the kit receptor in TF-1 was also observed on exposure to kit ligand-negative stroma, thus indicating the need for heterologous receptor ligand interaction. Removal of stroma induced upregulation by 2 to 4 orders of magnitude. Downregulation and upregulation of c-kit expression could also be shown for the megakaryocytic progenitor cell line M-07e and was comparable to that of TF-1, indicating that stroma-dependent regulation of c-kit is a general mechanism. Downregulation may be an economic way to compensate for the increased sensitivity of the c-kit/ligand interaction on stroma. The stroma-dependent c-kit regulation most likely occurs at the transcriptional level, because mechanisms, such as splicing, attenuation, differential promoter usage, or mRNA stability, could be excluded.

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