scholarly journals Dibenzo[f,h]furazano[3,4-b]quinoxalines: Synthesis by Intramolecular Cyclization through Direct Transition Metal-Free C–H Functionalization and Electrochemical, Photophysical, and Charge Mobility Characterization

ACS Omega ◽  
2020 ◽  
Vol 5 (14) ◽  
pp. 8200-8210
Author(s):  
Yuriy A. Kvashnin ◽  
Egor V. Verbitskiy ◽  
Oleg S. Eltsov ◽  
Pavel A. Slepukhin ◽  
Alexey R. Tameev ◽  
...  
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Direct Transition ◽  
Charge Mobility ◽  
Metal Free

scholarly journals Metal Free Amino-Oxidation of Electron Rich Alkenes Mediated by an Oxoammonium Salt

2020 ◽  
Author(s):  
Alexandra Millimaci ◽  
Rowan Meador ◽  
Sara Dampf ◽  
John D. Chisholm
Keyword(s):  
Transition Metal ◽  
Solvent Effects ◽  
Free Amino ◽  
Oxidation Products ◽  
Direct Transition ◽  
Metal Free ◽  
Mild Conditions ◽  
Relative Stereochemistry ◽  
Oxoammonium Salt

<div> <div> <div> <p>4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium tetrafluoroborate (Bobbitt’s salt) effectively activates electron rich alkenes and promotes the addition of anilines. This transformation provides a direct, transition metal free method for amino-oxidation of alkenes under mild conditions. The relative stereochemistry of the amino-oxidation is influenced by solvent effects, with both the syn and anti amino-oxidation products being accessible from identical starting materials. </p> </div> </div> </div>

Access to Furo[2,3‐ b ]pyridines by Transition‐Metal‐Free Intramolecular Cyclization of C3‐substituted Pyridine N ‐oxides

2018 ◽  
Vol 7 (5) ◽  
pp. 879-882 ◽  
Author(s):  
Dong Wang ◽  
Meng Shen ◽  
Yuxi Wang ◽  
Jianyong Hu ◽  
Junjie Zhao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Metal Free

Synthesis of Imidazo[1,5-a]quinolines via Metal-Free Oxidative Amination of sp3 C–H Bonds

Synthesis ◽  
2018 ◽  
Vol 50 (14) ◽  
pp. 2761-2767 ◽  
Author(s):  
Chen Ma ◽  
Huanhuan Liu ◽  
Xinfeng Wang
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Efficient Synthesis ◽  
Oxidative Amination ◽  
Metal Free ◽  
Oxidation System

A novel oxidative amination of sp3 C–H bonds was developed for the efficient synthesis of imidazo[1,5-a]quinolines from readily available α-amino acids and (2-azaaryl)methanes. This domino protocol, which was established in a TBAI-TBHP oxidation system, includes transition-metal-free decarboxylation and intramolecular cyclization. This method represented a new avenue for the synthesis of N-heterocycles using 2-methylquinolines as the synthon of quinoline-2-carbaldehydes.

scholarly journals Base-Catalyzed Synthesis of Flavones via Thiol-Assisted Sequential Demethylation/Cyclization of 1-(2-methoxyphenyl)prop-2-yn-1-ones

2021 ◽  
Author(s):  
Ritiele Heck ◽  
Thiago Anjos ◽  
Maira R Giehl ◽  
Ricardo F Schumacher ◽  
Benhur Godoi
Keyword(s):  
Reaction Time ◽  
Secondary Metabolites ◽  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Important Class ◽  
Short Reaction Time ◽  
Metal Free ◽  
Synthetic Strategy ◽  
Pharmacologically Active ◽  
Active Substances

Flavone and analogues represent an important class of biologically and pharmacologically active substances commonly found in the composition of diverse plants as part of the class of secondary metabolites. Herein, we have demonstrated an efficient and regioselective synthetic strategy for the preparation of functionalized flavones through sequential demethylation/6-endo-dig intramolecular cyclization of propyn-1-ones, using catalytic amounts of base in the presence of a thiol, by employing NMP as the solvent. The reactions proceeded smoothly under transition-metal-free and open to air conditions, furnishing the desired six-membered heterocycles in moderate to excellent yields, in short reaction time.

ChemInform Abstract: Direct Transition Metal Free C-S Bond Formation: Synthesis of 2-Aminobenzothiazole Derivatives via Base-Mediated Approach.

ChemInform ◽  
2012 ◽  
Vol 43 (47) ◽  
pp. no-no
Author(s):  
Rui Wang ◽  
Zhi Chen ◽  
Liang Yue ◽  
Wei Pan ◽  
Jun-Jie Zhao
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Direct Transition ◽  
Metal Free

Direct transition metal-free C–S bond formation: synthesis of 2-aminobenzothiazole derivatives via base-mediated approach

2012 ◽  
Vol 53 (34) ◽  
pp. 4529-4531 ◽  
Author(s):  
Rui Wang ◽  
Zhi Chen ◽  
Liang Yue ◽  
Wei Pan ◽  
Jun-Jie Zhao
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Direct Transition ◽  
Metal Free

scholarly journals Metal Free Amino-Oxidation of Electron Rich Alkenes Mediated by an Oxoammonium Salt

2020 ◽  
Author(s):  
Alexandra Millimaci ◽  
Rowan Meador ◽  
Sara Dampf ◽  
John D. Chisholm
Keyword(s):  
Transition Metal ◽  
Solvent Effects ◽  
Free Amino ◽  
Oxidation Products ◽  
Direct Transition ◽  
Metal Free ◽  
Mild Conditions ◽  
Relative Stereochemistry ◽  
Oxoammonium Salt

<div> <div> <div> <p>4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium tetrafluoroborate (Bobbitt’s salt) effectively activates electron rich alkenes and promotes the addition of anilines. This transformation provides a direct, transition metal free method for amino-oxidation of alkenes under mild conditions. The relative stereochemistry of the amino-oxidation is influenced by solvent effects, with both the syn and anti amino-oxidation products being accessible from identical starting materials. </p> </div> </div> </div>

ChemInform Abstract: Direct Transition-Metal-Free Intramolecular C-O Bond Formation: Synthesis of Benzoxazole Derivatives.

ChemInform ◽  
2011 ◽  
Vol 42 (23) ◽  
pp. no-no
Author(s):  
Jinsong Peng ◽  
Cuijuan Zong ◽  
Min Ye ◽  
Tonghui Chen ◽  
Dewei Gao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Direct Transition ◽  
Metal Free

scholarly journals Direct Transition-Metal-Free Intramolecular Arylation of Phenols

2008 ◽  
Vol 10 (20) ◽  
pp. 4625-4628 ◽  
Author(s):  
Gan B. Bajracharya ◽  
Olafs Daugulis
Keyword(s):  
Transition Metal ◽  
Direct Transition ◽  
Metal Free
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