Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo–Chemo Combination Therapy

ACS Nano ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 1958-1970 ◽  
Author(s):  
Zhaoqing Cong ◽  
Lu Zhang ◽  
Si-Qi Ma ◽  
Kit S. Lam ◽  
Fei-Fei Yang ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Tumor Penetration ◽  
Self Assembling ◽  
Peptide Nanoparticles

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer

2017 ◽  
Vol 27 (20) ◽  
pp. 1606530 ◽  
Author(s):  
Fangyuan Zhou ◽  
Bing Feng ◽  
Tingting Wang ◽  
Dangge Wang ◽  
Qingshuo Meng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combination Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tumor Penetration

Size‐Transformable Bicomponent Peptide Nanoparticles for Deep Tumor Penetration and Photo‐Chemo Combined Antitumor Therapy

Small ◽  
2021 ◽  
pp. 2106291
Author(s):  
Teng Ma ◽  
Rong Chen ◽  
Niannian Lv ◽  
Yu Chen ◽  
Huiming Qin ◽  
...  
Keyword(s):  
Antitumor Therapy ◽  
Tumor Penetration ◽  
Peptide Nanoparticles

scholarly journals pH-Sensitive self-assembling nanoparticles for tumor near-infrared fluorescence imaging and chemo–photodynamic combination therapy

Nanoscale ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 104-116 ◽  
Author(s):  
Wenxiu Hou ◽  
Xin Zhao ◽  
Xiaoqing Qian ◽  
Fei Pan ◽  
Chunlei Zhang ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Fluorescence Imaging ◽  
Combination Treatment ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Near Infrared Fluorescence ◽  
Self Assembling ◽  
Near Infrared Fluorescence Imaging

pH-Sensitive self-assembling anti-tumor prodrug nanoparticles for the diagnosis and chemo-photodynamic combination treatment of tumor.

scholarly journals Advancement of Peptide Nanobiotechnology via Emerging Microfluidic Technology

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 627 ◽  
Author(s):  
Chan ◽  
Tay
Keyword(s):  
Functional Groups ◽  
Cell Cultures ◽  
Self Assembly ◽  
Nanoparticle Size ◽  
Promising Technique ◽  
Self Assembling ◽  
Microfluidic Technology ◽  
Physical Shape ◽  
Peptide Nanoparticles ◽  
Shape And Size

Peptide nanotechnology has experienced a long and enduring development since its inception. Many different applications have been conceptualized, which depends on the functional groups present on the peptide and the physical shape/size of the peptide nanostructures. One of the most prominent nanostructures formed by peptides are nanoparticles. Until recently, however, it has been challenging to engineer peptide nanoparticles with low dispersity. An emerging and promising technique involves the utility of microfluidics to produce a solution of peptide nanoparticles with narrow dispersity. In this process, two or more streams of liquid are focused together to create conditions that are conducive towards the formation of narrowly dispersed samples of peptide nanoparticles. This makes it possible to harness peptide nanoparticles for the myriad of applications that are dependent on nanoparticle size and uniformity. In this focus review, we aim to show how microfluidics may be utilized to (1) study peptide self-assembly, which is critical to controlling nanostructure shape and size, and peptide-interface interactions, and (2) generate self-assembling peptide-based microgels for miniaturized cell cultures. These examples will illustrate how the emerging microfluidic approach promises to revolutionize the production and application of peptide nanoparticles in ever more diverse fields than before.

pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. 1097-1112 ◽  
Author(s):  
Guiyang Zhang ◽  
Huilin Gou ◽  
Yanfeng Liu ◽  
Kai Xi ◽  
Dechen Jiang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Combination Therapy ◽  
Low Power ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Oxide Nanoparticles ◽  
Treatment Efficiency ◽  
High Tendency ◽  
Normal Tissues ◽  
Self Assembling

Aim: To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy. Materials & methods: The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated. Results: The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues. Conclusion: The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.

Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

Biomaterials ◽  
2018 ◽  
Vol 168 ◽  
pp. 64-75 ◽  
Author(s):  
Chuan Hu ◽  
Xingli Cun ◽  
Shaobo Ruan ◽  
Rui Liu ◽  
Wei Xiao ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Tumor Penetration ◽  
No Release
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