The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue

ACS Nano ◽  
2018 ◽  
Vol 12 (11) ◽  
pp. 11139-11151 ◽  
Author(s):  
Xiangchun Zhang ◽  
Ru Liu ◽  
Qing Yuan ◽  
Fuping Gao ◽  
Jiaojiao Li ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Cancer Invasion ◽  
Cancer Tissue ◽  
Primary Cancer ◽  
Precise Diagnosis ◽  
Diagnosis Of Cancer ◽  
Mass Mapping

scholarly journals How Does a Tumor Get Its Shape? MicroRNAs Act as Morphogens at the Cancer Invasion Front

2020 ◽  
Vol 6 (2) ◽  
pp. 23 ◽  
Author(s):  
Catalin Vasilescu ◽  
Mihai Tanase ◽  
Dana Giza ◽  
Livia Procopiuc ◽  
Mihnea P. Dragomir ◽  
...  
Keyword(s):  
Fractal Dimension ◽  
Reaction Diffusion ◽  
Cancer Invasion ◽  
Target Cells ◽  
Invasion Front ◽  
Reaction Diffusion Model ◽  
Cancer Aggressiveness ◽  
Diagnosis Of Cancer ◽  
Front Shape ◽  
Dose Dependent

The generation and organization of the invasion front shape of neoplasms is an intriguing problem. The intimate mechanism is not yet understood, but the prevailing theory is that it represents an example of morphogenesis. Morphogenesis requires the presence of specific molecules, known as morphogens (activators and inhibitors), which can diffuse and elicit dose-dependent responses in their target cells. Due to their ability to modulate most of the coding transcriptome, their well-established role in embryogenesis, and their capacity to rapidly move between neighboring and distant cells, we propose microRNAs as inhibitors that could shape the cancer invasion front. In order to explain the genesis of the tumor border, we use Alan Turing’s reaction diffusion model, refined by Meinhardt and Gierer. This assumes the existence of an activator called a, and an inhibitor called h, which we hypothesize could be a freely moving microRNA. We used the fractal dimension as a measure of tumor border irregularity. We observed that the change in fractal dimension associates with variations in the diffusion coefficient of the activator (Da) or the inhibitor (Dh). We determined that the fractal dimension remains constant (i.e., the irregularity of the tumor border does not change) across a Dh interval, which becomes narrower as Da rises. We therefore conclude that a change in fractal dimension occurs when the balance between Da and Dh is disrupted. Biologically, this could be explained by a faulty distribution of the inhibitor caused by an abnormal density of the intercellular connection network. From a translational perspective, if experimentally confirmed, our observations can be used for a better diagnosis of cancer aggressiveness.

NSD3-NUT-expressing midline carcinoma of the lung: First characterization of primary cancer tissue

2015 ◽  
Vol 211 (5) ◽  
pp. 404-408 ◽  
Author(s):  
Shioto Suzuki ◽  
Nobuya Kurabe ◽  
Ippei Ohnishi ◽  
Kazumasa Yasuda ◽  
Yoichiro Aoshima ◽  
...  
Keyword(s):  
Cancer Tissue ◽  
Primary Cancer

7231 A study of the layer structure of the gastric wall and diagnosis of cancer invasion by using 30mhzultrasonographic probe.

2000 ◽  
Vol 51 (4) ◽  
pp. AB300
Author(s):  
Hiroyuki Konishi ◽  
Yoko Murata ◽  
Maiko Kishino ◽  
Yoko Fukazawa ◽  
Shinichi Nakamura ◽  
...  
Keyword(s):  
Layer Structure ◽  
Gastric Wall ◽  
Cancer Invasion ◽  
Diagnosis Of Cancer

scholarly journals Healthcare utilisation in general practice and hospitals in the year preceding a diagnosis of cancer recurrence or second primary cancer: a population-based register study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Linda Aagaard Rasmussen ◽  
Henry Jensen ◽  
Line Flytkjær Virgilsen ◽  
Alina Zalounina Falborg ◽  
Henrik Møller ◽  
...  
Keyword(s):  
General Practice ◽  
Cancer Survivors ◽  
Cancer Recurrence ◽  
Healthcare Utilisation ◽  
Healthcare Setting ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Diagnosis Of Cancer

Abstract Background The organisation of cancer follow-up is under scrutiny in many countries, and general practice is suggested to become more involved. A central focus is timely detection of recurring previous cancer and new second primary cancer. More knowledge on the patient pathway before cancer recurrence and second primary cancer is warranted to ensure the best possible organisation of follow-up. We aimed to describe the healthcare utilisation in the year preceding a diagnosis of cancer recurrence or second primary cancer. Methods This nationwide register study comprises patients diagnosed with bladder, breast, colorectal, endometrial, lung, malignant melanoma and ovarian cancer in Denmark in 2008–2016. The frequency of healthcare contacts during the 12 months preceding a cancer recurrence or second primary cancer was estimated and compared to the frequency of cancer survivors in cancer remission. The main analyses were stratified on sex and healthcare setting. Furthermore, two sub-analyses were stratified on 1) sex, healthcare setting and age group and on 2) sex, healthcare setting and comorbidity status. Results The study population consisted of 7832 patients with recurrence and 2703 patients with second primary cancer. On average, the patients were in contact with general practice one time per month in the 12th month preceding a new cancer diagnosis (recurrence or second primary cancer). Increasing contact rates were seen from 7 months before diagnosis in general practice and from 12 months before diagnosis in hospitals. This pattern was more pronounced in patients with cancer recurrence, younger patients and patients with no comorbidity. For instance, the contact rate ratios for hospital contacts in non-comorbid women with recurrence demonstrated 30% more contacts in the 12th month before recurrence and 127% more contacts in the 2nd month before recurrence. Conclusions The results show that cancer survivors are already seen in general practice on a regular basis. The increasing contact rates before a diagnosis of cancer recurrence or second primary cancer indicate that a window of opportunity exists for more timely diagnosis; this is seen in both general practice and in hospitals. Thus, cancer survivors may benefit from improvements in the organisation of cancer follow-up.

scholarly journals Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting

2016 ◽  
Vol 9 ◽  
pp. 23-30 ◽  
Author(s):  
Thomas Mandel Clausen ◽  
Marina Ayres Pereira ◽  
Htoo Zarni Oo ◽  
Mafalda Resende ◽  
Tobias Gustavson ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Real Time ◽  
Binding Kinetics ◽  
Cancer Tissue ◽  
Primary Cancer ◽  
Label Free ◽  
Tissue Specimens

Tactics of cancer invasion: solitary and collective invasion

2020 ◽  
Vol 167 (4) ◽  
pp. 347-355 ◽  
Author(s):  
Tomoaki Nagai ◽  
Tomohiro Ishikawa ◽  
Yasuhiro Minami ◽  
Michiru Nishita
Keyword(s):  
Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Cancer Invasion ◽  
Cancer Tissue ◽  
Mesenchymal Transition ◽  
Collective Invasion ◽  
Invasion Model ◽  
Cell To Cell Adhesion ◽  
State Form

Abstract Much attention has been paid on the mechanism of cancer invasion from the viewpoint of the behaviour of individual cancer cells. On the other hand, histopathological analyses of specimens from cancer patients and of cancer invasion model animals have revealed that cancer cells often exhibit collective invasion, characterized by sustained cell-to-cell adhesion and polarized invasion as cell clusters. Interestingly, it has recently become evident that during collective invasion of cancer cells, the cells localized at invasion front (leader cells) and the cells following them (follower cells) exhibit distinct cellular characteristics, and that there exist the cells expressing representative proteins related to both epithelial and mesenchymal properties simultaneously, designated as hybrid epithelial-to-mesenchymal transition (EMT)-induced cells, in cancer tissue. Furthermore, the findings that cells adopted in hybrid EMT state form clusters and show collective invasion in vitro emphasize an importance of hybrid EMT-induced cells in collective cancer invasion. In this article, we overview recent findings of the mechanism underlying collective invasion of cancer cells and discuss the possibility of controlling cancer invasion and metastasis by targeting this process.

scholarly journals microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance

Cancers ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 7 ◽  
Author(s):  
Ning Wang ◽  
Hor-Yue Tan ◽  
Yi-Gang Feng ◽  
Cheng Zhang ◽  
Feiyu Chen ◽  
...  
Keyword(s):  
Human Cancer ◽  
Migration And Invasion ◽  
Cancer Tissue ◽  
Specific Marker ◽  
Tumor Treatment ◽  
Multiple Gene ◽  
Early Diagnosis Of Cancer ◽  
Different Types ◽  
Diagnosis Of Cancer

microRNA-23a (miR-23a) is one of the most extensively studied miRNAs in different types of human cancer, and plays various roles in the initiation, progression, and treatment of tumors. Here, we comprehensively summarize and discuss the recent findings about the role of miR-23a in cancer. The differential expression of tissue miR-23a was reported, potentially indicating cancer stages, angiogenesis, and metastasis. miR-23a in human biofluid, such as plasma and salivary fluid, may be a sensitive and specific marker for early diagnosis of cancer. Tissue and circulating miR-23a serves as a prognostic factor for cancer patient survival, as well as a predictive factor for response to anti-tumor treatment. The direct and indirect regulation of miR-23a on multiple gene expression and signaling transduction mediates carcinogenesis, tumor proliferation, survival, cell migration and invasion, as well as the response to anti-tumor treatment. Tumor cell-derived miR-23a regulates the microenvironment of human cancer through manipulating both immune function and tumor vascular development. Several transcriptional and epigenetic factors may contribute to the dysregulation of miR-23a in cancer. This evidence highlights the essential role of miR-23a in the application of cancer diagnosis, prognosis, and treatment.

Erythrocyte-derived vesicles for circulating tumor cell capture and specific tumor imaging

Nanoscale ◽  
2019 ◽  
Vol 11 (25) ◽  
pp. 12388-12396 ◽  
Author(s):  
Ming Chen ◽  
Ao Liu ◽  
Bei Chen ◽  
Dao-Ming Zhu ◽  
Wei Xie ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Imaging ◽  
Circulating Tumor Cell ◽  
Research Interest ◽  
Cell Capture ◽  
Specific Tumor ◽  
Precise Diagnosis ◽  
Diagnosis Of Cancer

The precise diagnosis of cancer remains a great challenge; therefore, it is our research interest to develop safe, tumor-specific reagents.

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