scholarly journals “Waltz” of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand–Receptor Binding

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 11871-11880 ◽  
Author(s):  
Yanqi Yu ◽  
Yuan Gao ◽  
Yan Yu
Keyword(s):  
Cell Membrane ◽  
Lipid Bilayers ◽  
Receptor Binding ◽  
Single Particle ◽  
Particle Rotation ◽  
Coated Nanoparticles

scholarly journals Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3428
Author(s):  
Chaojie Zhu ◽  
Junkai Ma ◽  
Zhiheng Ji ◽  
Jie Shen ◽  
Qiwen Wang
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Membrane ◽  
Preventive Therapy ◽  
Peripheral Vascular ◽  
Coating Technology ◽  
Immune Clearance ◽  
Coated Nanoparticles ◽  
Membrane Coating ◽  
Therapeutic Tools

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

scholarly journals Non-axisymmetric shapes of biological membranes from locally induced curvature

2019 ◽  
Author(s):  
Yannick A. D. Omar ◽  
Amaresh Sahu ◽  
Roger A. Sauer ◽  
Kranthi K. Mandadapu
Keyword(s):  
Phase Separation ◽  
Cell Membrane ◽  
Viscous Flow ◽  
Lipid Bilayers ◽  
Biological Membranes ◽  
Rate Of Change ◽  
Computational Studies ◽  
Biological Processes ◽  
Resting Tension ◽  
Physical Phenomena

In various biological processes such as endocytosis and caveolae formation, the cell membrane is locally deformed into curved configurations. Previous theoretical and computational studies to understand membrane morphologies resulting from locally induced curvature are often limited to axisymmetric shapes, which severely restricts the physically admissible morphologies. Under the restriction of axisymmetry, past efforts predict that the cell membrane buds at low resting tensions and stalls at a flat pit at high resting tensions. In this work, we lift the restriction of axisymmetry by employing recent theoretical and numerical advances to understand arbitrarily curved and deforming lipid bilayers. Our non-axisymmetric morphologies reveal membrane morphologies which agree well with axisymmetric studies—however only if the resting tension of the membrane is low. When the resting tension is moderate to high, we show that (i) axisymmetric invaginations are unstable; and (ii) non-axisymmetric ridge-shaped structures are energetically favorable. We further study the dynamical effects resulting from the interplay between intramembrane viscous flow and induced curvature, and find the rate at which the locally induced curvature increases is a key determinant in the formation of ridges. In particular, we show that axisymmetric buds are favored when the induced curvature is rapidly increased, while non-axisymmetric ridges are favored when the curvature is slowly increased: The rate of change of induced curvature affects the intramembrane viscous flow of lipids, which can impede the membrane’s ability to transition into ridges. We conclude that the appearance of non-axisymmetric ridges indicates that axisymmetry cannot be generally assumed when understanding processes involving locally induced curvature. Our results hold potentially relevant implications for biological processes such as endocytosis, and physical phenomena like phase separation in lipid bilayers.

Hybrid cell membrane-coated nanoparticles: A multifunctional biomimetic platform for cancer diagnosis and therapy

2020 ◽  
Vol 112 ◽  
pp. 1-13 ◽  
Author(s):  
Hong-Ying Chen ◽  
Jiang Deng ◽  
Yu Wang ◽  
Cheng-Qiong Wu ◽  
Xian Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Diagnosis ◽  
Hybrid Cell ◽  
Diagnosis And Therapy ◽  
Coated Nanoparticles ◽  
Cancer Diagnosis And Therapy

Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy

Nano Letters ◽  
2019 ◽  
Vol 20 (2) ◽  
pp. 936-946 ◽  
Author(s):  
Di Nie ◽  
Zhuo Dai ◽  
Jialin Li ◽  
Yiwei Yang ◽  
Ziyue Xi ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Cancer Chemotherapy ◽  
Shell Structure ◽  
Coated Nanoparticles

Affordable Membrane Permeability Calculations: Permeation of Short-Chain Alcohols through Pure-Lipid Bilayers and a Mammalian Cell Membrane

2019 ◽  
Vol 15 (5) ◽  
pp. 2913-2924 ◽  
Author(s):  
Chi Hang Tse ◽  
Jeffrey Comer ◽  
Simon Kit Sang Chu ◽  
Yi Wang ◽  
Christophe Chipot
Keyword(s):  
Cell Membrane ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Mammalian Cell ◽  
Short Chain

Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery

2021 ◽  
Author(s):  
Mian Wang ◽  
Yuanfeng Xin ◽  
Hao Cao ◽  
Wanlu Li ◽  
Yifei Hua ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Membrane ◽  
Coated Nanoparticles ◽  
Recent Advances

Studies of nanomedicine have achieved dramatic progress in recent decades.

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