scholarly journals Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype

ACS Nano ◽  
2018 ◽  
Vol 12 (10) ◽  
pp. 9669-9679 ◽  
Author(s):  
Ryan M. Davis ◽  
Bernhard Kiss ◽  
Dharati R. Trivedi ◽  
Thomas J. Metzner ◽  
Joseph C. Liao ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Cancer Tissue ◽  
Molecular Phenotype ◽  
Surface Enhanced ◽  
Multiplexed Imaging ◽  
Surface Enhanced Raman ◽  
Bladder Cancer Tissue ◽  
Enhanced Raman Scattering

scholarly journals Stimulus-responsive surface-enhanced Raman scattering: a “Trojan horse” strategy for precision molecular diagnosis of cancer

2020 ◽  
Vol 11 (24) ◽  
pp. 6111-6120 ◽  
Author(s):  
Cai Zhang ◽  
Xiaoyu Cui ◽  
Jie Yang ◽  
Xueguang Shao ◽  
Yuying Zhang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Molecular Diagnosis ◽  
Surface Enhanced Raman Scattering ◽  
Molecular Phenotype ◽  
Tumor Tissues ◽  
Surface Enhanced ◽  
Stimulus Responsive ◽  
Surface Enhanced Raman ◽  
Diagnosis Of Cancer ◽  
Enhanced Raman Scattering

A stimulus-responsive surface-enhanced Raman scattering (SR-SERS) technique was developed to selectively profile the comprehensive molecular phenotype of tumor tissues.

scholarly journals A Real-Time Clinical Endoscopic System for Intraluminal, Multiplexed Imaging of Surface-Enhanced Raman Scattering Nanoparticles

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123185 ◽  
Author(s):  
Ellis Garai ◽  
Steven Sensarn ◽  
Cristina L. Zavaleta ◽  
Nathan O. Loewke ◽  
Stephan Rogalla ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Real Time ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Multiplexed Imaging ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Surface-Enhanced Raman Scattering Spectroscopic Assay of Immunohistochemically Stained Human Colon Cancer Tissue

2011 ◽  
Vol 38 (9) ◽  
pp. 0904001
Author(s):  
席刚琴 Xi Gangqin ◽  
陈燕坪 Chen Yanping ◽  
陈刚 Chen Gang ◽  
郑雄伟 Zheng Xiongwei ◽  
冯尚源 Feng Shangyuan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Raman Scattering ◽  
Human Colon ◽  
Surface Enhanced Raman Scattering ◽  
Cancer Tissue ◽  
Colon Cancer Tissue ◽  
Human Colon Cancer ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A Molecular Beacon Based Surface-Enhanced Raman Scattering Nanotag for Noninvasive Diagnosis of Bladder Cancer

2019 ◽  
Vol 15 (7) ◽  
pp. 1589-1597 ◽  
Author(s):  
Pu Zhang ◽  
Yanning Zhang ◽  
Wenhao Liu ◽  
Daxiang Cui ◽  
Xiangwei Zhao ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Raman Scattering ◽  
Cancer Diagnosis ◽  
Surface Enhanced Raman Scattering ◽  
Clinical Samples ◽  
Au Nanoclusters ◽  
Good Efficiency ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Current techniques responsible for bladder cancer diagnosis and monitoring are insensitive and invasive. Here, we report a surface-enhanced Raman scattering nanotag for the sensitive diagnosis of bladder cancer using urine samples as a noninvasive approach. The sea-urchin-like Au nanoclusters used in this work exhibit excellent surface-enhanced Raman scattering ability with an enhancement factor of 3.44 × 107. Molecular beacons labeled with Cy3 are covalently anchored to the surface of Au nanoclusters, which serve as a specific recognition site for survivin mRNA. Further a polyethylene glycol coating provides stability and completes the final functionalization. This surface-enhanced Raman scattering nanotag has good efficiency (equilibrium time: 10 min) with high sensitivity (detection threshold: 19.4 nM), high specificity (capable of single-base mismatch recognition) and good stability against nucleases. All these features are also verified in the fluorescence modality. Furthermore, its function was highly maintained in clinical samples from 13 patients with bladder cancer, as evidenced by a sensitivity up to 91.7% and a specificity up to 100%. The nanotag demonstrates its superiority over cytology and has its great clinical value even for early bladder cancer diagnosis. Thus, the nanotag is promising for noninvasive and sensitive diagnosis of bladder cancer.

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