Transformable Nanomaterials as an Artificial Extracellular Matrix for Inhibiting Tumor Invasion and Metastasis

ACS Nano ◽  
2017 ◽  
Vol 11 (4) ◽  
pp. 4086-4096 ◽  
Author(s):  
Xiao-Xue Hu ◽  
Ping-Ping He ◽  
Guo-Bin Qi ◽  
Yu-Juan Gao ◽  
Yao-Xin Lin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tumor Invasion ◽  
Invasion And Metastasis ◽  
Artificial Extracellular Matrix

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 ◽  
Vol 7 (15) ◽  
pp. 1434-1441 ◽  
Author(s):  
William G. Stetler‐Stevenson ◽  
Lance A. Liotta ◽  
David E. Kleiner
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Tumor Invasion ◽  
Invasion And Metastasis

The regulation of anoikis in tumor invasion and metastasis

2013 ◽  
Vol 35 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Hong SU ◽  
Xiao-Yu SI ◽  
Wen-Ru TANG ◽  
Ying LUO
Keyword(s):  
Tumor Invasion ◽  
Invasion And Metastasis

scholarly journals Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 21
Author(s):  
Mina Keshvardoostchokami ◽  
Sara Seidelin Majidi ◽  
Peipei Huo ◽  
Rajan Ramachandran ◽  
Menglin Chen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Polymer Composite ◽  
Electrospun Nanofibers ◽  
Synthetic Polymer ◽  
Inorganic Materials ◽  
Host Cells ◽  
Natural Polymer ◽  
Reinforced Polymers ◽  
Nanofibrous Scaffolds ◽  
Artificial Extracellular Matrix

Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.

scholarly journals The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Eui Jung Moon ◽  
Stephano S. Mello ◽  
Caiyun G. Li ◽  
Jen-Tsan Chi ◽  
Kaushik Thakkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Invasion ◽  
Critical Role ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Invasion And Metastasis ◽  
Stat3 Signaling ◽  
Inducible Genes ◽  
Transcriptional Target

AbstractHypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In this study, we identify v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) as a potent regulator of tumor invasion without affecting cell viability. MAFF expression is elevated in metastatic breast cancer patients and is specifically correlated with hypoxic tumors. Combined ChIP- and RNA-sequencing identifies IL11 as a direct transcriptional target of the heterodimer between MAFF and BACH1, which leads to activation of STAT3 signaling. Inhibition of IL11 results in similar levels of metastatic suppression as inhibition of MAFF. This study demonstrates the oncogenic role of MAFF as an activator of the IL11/STAT3 pathways in breast cancer.

Angiogenesis: molecular mechanisms and functional interactions

2003 ◽  
Vol 89 (01) ◽  
pp. 190-197 ◽  
Author(s):  
Georg Breier ◽  
Hellmut Augustin
Keyword(s):  
Growth Factors ◽  
Research Program ◽  
Tumor Invasion ◽  
Molecular Mechanisms ◽  
Precursor Cells ◽  
Invasion And Metastasis ◽  
Angiogenic Growth Factors ◽  
Cell Contacts ◽  
Functional Interactions ◽  
Biannual Meeting

SummaryThe German Priority Research Program “Angiogenesis” (www.angiogenese.de) hosts a biannual meeting in the Kloster Seeon in Southern Germany. The 2nd Kloster Seeon Meeting “Angiogenesis: Molecular Mechanisms and Functional Interactions” was held in September 2002. It included sessions on hypoxia, the biology of endothelial precursor cells, angiogenic growth factors including VEGFs, the angiopoietins, ephrins, and FGFs, mechanisms of vascular sprouting and cell-cell contacts during angiogenesis, angiogenic signaling, lymphangiogenesis, angiogenesis during tumor invasion and metastasis, and on novel angiomanipulatory therapies. This report summarizes the key findings reported during the platform presentations of the meeting.

IgG-recognizing shed tumor-associated antigens can promote tumor invasion and metastasis

2001 ◽  
Vol 50 (7) ◽  
pp. 361-372 ◽  
Author(s):  
Julie K. Nyhus ◽  
Chris C. Wolford ◽  
Chad R. Friece ◽  
Bud M. Nelson ◽  
James W. Sampsel ◽  
...  
Keyword(s):  
Tumor Invasion ◽  
Invasion And Metastasis ◽  
Tumor Associated Antigens

Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts

2002 ◽  
Vol 85 (4) ◽  
pp. 785-797 ◽  
Author(s):  
Souvenir D. Tachado ◽  
Mark W. Mayhew ◽  
Ginger G. Wescott ◽  
Tonia L. Foreman ◽  
Crystal D. Goodwin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Invasion ◽  
Invasion And Metastasis ◽  
Kinase C ◽  
Protein Kinase C Epsilon
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