Gold Nanorods Based Air Scanning Electron Microscopy and Diffusion Reflection Imaging for Mapping Tumor Margins in Squamous Cell Carcinoma

ACS Nano ◽  
2016 ◽  
Vol 10 (2) ◽  
pp. 2349-2356 ◽  
Author(s):  
Rinat Ankri ◽  
Ariel Ashkenazy ◽  
Yonat Milstein ◽  
Yaniv Brami ◽  
Asaf Olshinka ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gold Nanorods ◽  
Tumor Margins ◽  
Diffusion Reflection ◽  
And Diffusion ◽  
Scanning Electron

scholarly journals Angioarchitecture of squamous cell carcinoma from hamster buccal pouch: a scanning electron microscopy study

Scanning ◽  
2009 ◽  
Vol 31 (5) ◽  
pp. 188-194 ◽  
Author(s):  
Laura Beatriz Oliveira De Oliveira ◽  
Vinícius Faccin Bampi ◽  
Carolina Ferreira Gomes ◽  
Maria Antonieta Lopes De Souza
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Scanning Electron Microscopy Study ◽  
Hamster Buccal Pouch ◽  
Scanning Electron

Electron Microscopy of Superficial Vesical Neoplasms: Preliminary Reports

1992 ◽  
Vol 59 (1) ◽  
pp. 96-100 ◽  
Author(s):  
A. Fandella ◽  
L. Maccatrozzo ◽  
F. Merlo ◽  
G. Tuccitto ◽  
M. Mangano ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Bladder Cancer ◽  
Cell Carcinoma ◽  
Lower Risk ◽  
Superficial Bladder Cancer ◽  
Prognostic Index ◽  
Neoplastic Disease ◽  
Bladder Cell ◽  
Scanning Electron

The aim of this work was to study with scanning electron microscopy (SEM) the morphologic patterns of the lesions caused by superficial bladder cell carcinoma and to evaluate the possibility of using this method as prognostic index. Our observations showed three different kinds of morphologic patterns (wrinkled cell, dismorphic cells and cells with microvilli) of the neoplastic urothelium correlated with the evolution of the neoplastic disease. Results show that recurrence and invasiveness are more marked in the dismorphic cell kind, whereas the wrinkled cell kind represent a lower risk. SEM could be used as a parameter for biologically characterising superficial bladder cancer, as it is completely independent of neoplastic grading.

scholarly journals Diffusion Reflection Measurements of Antibodies Conjugated to Gold Nanoparticles as a Method to Identify Cutaneous Squamous Cell Carcinoma Borders

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 447
Author(s):  
Asaf Olshinka ◽  
Dean Ad-El ◽  
Elena Didkovski ◽  
Shirel Weiss ◽  
Rinat Ankri ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
False Positive Rate ◽  
False Negative ◽  
False Negative Rate ◽  
Residual Tumor ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Diffusion Reflection

Diffusion reflectance spectroscopy measurements targeted with gold nanoparticles (GNPs) can identify residual cutaneous squamous cell carcinoma (SCC) in excision borders. Human SCC specimens were stained with hematoxylin and eosin to identify tumor borders, and reflected onto an unstained deparaffinized section. Diffusion reflection of three sites (normal and SCC) were measured before and after GNPs targeting. Hyperspectral imaging showed a mean of 2.5 sites with tumor per specimen and 1.2 tumor-free (p < 0.05, t-test). GNPs were detected in 25/30 tumor sites (sensitivity 83.3%, false-negative rate 16.6%) and 12/30 non-tumor sites (specificity 60%, false-positive rate 40%). This study verifies the use of nanotechnology in identifying SCC tumor margins. Diffusion reflection scanning has high sensitivity for detecting the residual tumor.

The Effect of Indium Mole Fraction on the Growth Behavior of Your InxGa1-xAs Nanowires (NWs) Grown Using MOCVD

2013 ◽  
Vol 667 ◽  
pp. 224-230 ◽  
Author(s):  
Zulkafli Othaman ◽  
Edy Wibowo ◽  
Samsudi Sakrani
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Field Emission ◽  
Mole Fraction ◽  
Growth Mechanism ◽  
Growth Behavior ◽  
Uniform Diameter ◽  
And Diffusion ◽  
Scanning Electron

InxGa1-xAs NWs have been grown with various indium mole fractions (x) using MOCVD. The morphology of InxGa1-xAs NWs was observed using Field Emission-Scanning Electron Microscopy (FE-SEM) in order to study the growth behavior of the NWs. FE-SEM results show that the NWs growth mechanism has changed due to changing of indium mole fraction. At low indium mole fraction, the NWs grew via direct impinging mechanism which has produced NWs with relatively uniform diameter. By increasing the value of x the growth mechanism has transformed to the combination of direct impinging and diffusion of source atoms from the surface of substrate causing tapering of NWs. The degree of tapering increases with increasing value of indium mole fraction. InxGa1-xAs NW grown at x = 0.65 has the highest tapering factor, TF = 12.82, whereas NW grown at x = 0.41 has the lowest tapering factor, TF = 2.76.

scholarly journals Electron microscopy of squamous cell carcinoma of the head and neck

Scanning ◽  
2000 ◽  
Vol 22 (5) ◽  
pp. 326-331
Author(s):  
Håkan Leek ◽  
Maria Albertsson
Keyword(s):  
Electron Microscopy ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell

Desmoplastic Squamous Cell Carcinoma: Case Presentation and Literature Review

2008 ◽  
Vol 12 (5) ◽  
pp. 243-245 ◽  
Author(s):  
Alex Seal ◽  
David Zloty
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Postoperative Radiotherapy ◽  
Surgical Excision ◽  
Case Presentation ◽  
Tumor Margins ◽  
Squamous Cell Carcinoma Case ◽  
Prophylactic Lymph Node Dissection ◽  
Margin Control

Background: Desmoplastic squamous cell carcinoma (DSCC) is a variant of squamous cell carcinoma (SCC) with aggressive histologic and clinical features. DSCC has a 6 to 10 times higher rate of both local recurrence and metastatic spread compared with well-differentiated SCC. Clinical estimation of tumor margins can grossly underestimate both the depth and the peripheral extent of the tumor. Surgery with intraoperative margin control has been recommended. In many cases, postoperative radiotherapy or prophylactic lymph node dissection may be required. Case Presentation: A 71-year-old man with a biopsy positive for DSCC involving the left postauricular area was treated with nine-stage Mohs micrographic surgery before the tumor margins were negative. Conclusion: There are minimal reports in the literature pertaining to the presentation and treatment of DSCC; therefore, definitive conclusions are difficult. The depth of tumor penetration and peripheral spread of the DSCC presented in this case, however, supports the need for aggressive surgical excision, preferably with intraoperative margin control. To maximize the chance of cure, physicians must be aware of the distinct clinical and histologic features of DSCC and the aggressive treatment required.

Time to revisit the tumor margins in post NACT oral squamous cell carcinoma

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104679
Author(s):  
B.M. Joshna ◽  
Anand Subash ◽  
Shalini Thakur ◽  
Vishal Rao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Margins
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