Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy

ACS Nano ◽  
2015 ◽  
Vol 9 (10) ◽  
pp. 9678-9690 ◽  
Author(s):  
Seokyung Kang ◽  
Suk Ho Bhang ◽  
Sekyu Hwang ◽  
Jeong-Kee Yoon ◽  
Jaejung Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Photothermal Therapy

Effects of Freezing on Mesenchymal Stem Cells Labeled with Gold Nanoparticles

2020 ◽  
Vol 26 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Makenna K. Laffey ◽  
Kelsey P. Kubelick ◽  
Eleanor M. Donnelly ◽  
Stanislav Y. Emelianov
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells

Toxic effects of gold nanoparticles and gold ions in human umbilical cord derived mesenchymal stem cells

2015 ◽  
Vol 208 ◽  
pp. S101
Author(s):  
Gamze Tan ◽  
Necdet Sağlam ◽  
Melek Yaman ◽  
Nihan Örüklü ◽  
Emin Ümit Bağrıaçık
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Toxic Effects ◽  
Human Umbilical Cord

scholarly journals Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces

2014 ◽  
Vol 4 (1) ◽  
pp. 20130046 ◽  
Author(s):  
Rebecca Medda ◽  
Arne Helth ◽  
Patrick Herre ◽  
Darius Pohl ◽  
Bernd Rellinghaus ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Cell Surface ◽  
Surface Interactions ◽  
Bone Diseases ◽  
Population Heterogeneity ◽  
Human Mscs ◽  
Adult Mesenchymal Stem Cells ◽  
Cell Surface Interactions

Multi-potent adult mesenchymal stem cells (MSCs) derived from bone marrow have therapeutic potential for bone diseases and regenerative medicine. However, an intrinsic heterogeneity in their phenotype, which in turn results in various differentiation potentials, makes it difficult to predict the response of these cells. The aim of this study is to investigate initial cell–surface interactions of human MSCs on modified titanium alloys. Gold nanoparticles deposited on β-type Ti–40Nb alloys by block copolymer micelle nanolithography served as nanotopographical cues as well as specific binding sites for the immobilization of thiolated peptides present in several extracellular matrix proteins. MSC heterogeneity persists on polished and nanopatterned Ti–40Nb samples. However, cell heterogeneity and donor variability decreased upon functionalization of the gold nanoparticles with cyclic RGD peptides. In particular, the number of large cells significantly decreased after 24 h owing to the arrangement of cell anchorage sites, rather than peptide specificity. However, the size and number of integrin-mediated adhesion clusters increased in the presence of the integrin-binding peptide (cRGDfK) compared with the control peptide (cRADfK). These results suggest that the use of integrin ligands in defined patterns could improve MSC-material interactions, not only by regulating cell adhesion locally, but also by reducing population heterogeneity.

CYTOTOXICITY AND DIFFERENTIATION EFFECTS OF GOLD NANOPARTICLES TO HUMAN BONE MARROW MESENCHYMAL STEM CELLS

2011 ◽  
Vol 23 (02) ◽  
pp. 141-152 ◽  
Author(s):  
Jui-Hung Fan ◽  
Wen-Tyng Li ◽  
Wei-I Hung ◽  
Cheng-Pao Chen ◽  
Jui-Ming Yeh
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Medium Size ◽  
Continuous Exposure ◽  
Cell Death Pathway ◽  
Marrow Mesenchymal Stem Cells

Gold nanoparticles (GNPs) are widely used in chemical sensing, drug delivery, biomedical imaging, and photothermal therapy due to their strong and size-tunable surface plasmon resonance, fluorescence, and easy-surface functionalization. In this study, we investigated the effects of water-dispersed GNPs on the cytotoxicity and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) and the associated death pathway. The results showed that the viability of hBMSCs was dependent upon the size of GNPs. Further, GNPs at the smallest size exhibited the highest cytotoxicity after treatment for 5 days and also substantially suppressed the number of colony-forming unit-fibroblast (CFU-F) of hBMSCs after continuous exposure for 21 days. Although large and medium sizes of GNPs had minor cytotoxicity to the cells, the sizes of CFU-F formed in the groups treated with GNPs at medium and large sizes were smaller compared to the control group. Further study of the cell death pathway using GNPs at medium size found that GNPs triggered hBMSCs necrosis, possibly by oxidative stress after GNPs were endocytosed. In addition, GNPs exerted the inhibitory effects on induced osteogenesis and adipogenesis of hBMSCs. Alkaline phosphatase (ALP) activity and calcium mineralization during osteogenic induction as well as the accumulation of triacylglycerides in adipogenic hBMSCs were repressed significantly by coculturing with GNPs at medium size. Our results suggest that the application of GNPs as long-term tracers for the activities of mesenchymal stem cells (MSCs) should be carefully evaluated.

scholarly journals Correction: Delivering siRNA to control osteogenic differentiation and real-time detection of cell differentiation in human mesenchymal stem cells using multifunctional gold nanoparticles

2020 ◽  
Vol 8 (25) ◽  
pp. 5545-5546
Author(s):  
Qian Wu ◽  
Kaipeng Wang ◽  
Xichao Wang ◽  
Guohai Liang ◽  
Jinming Li
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Cell Differentiation ◽  
Osteogenic Differentiation ◽  
Real Time ◽  
Human Mesenchymal Stem Cells ◽  
Real Time Detection

Correction for ‘Delivering siRNA to control osteogenic differentiation and real-time detection of cell differentiation in human mesenchymal stem cells using multifunctional gold nanoparticles’ by Qian Wu et al., J. Mater. Chem. B, 2020, 8, 3016–3027, DOI: 10.1039/c9tb02899d.

Effect of gold nanoparticles on adipogenic differentiation of human mesenchymal stem cells

2011 ◽  
Vol 13 (12) ◽  
pp. 6789-6803 ◽  
Author(s):  
Yvonne Kohl ◽  
Erwin Gorjup ◽  
Alisa Katsen-Globa ◽  
Claudia Büchel ◽  
Hagen von Briesen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Adipogenic Differentiation ◽  
Human Mesenchymal Stem Cells
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