Nanoencapsulation for Probiotic Delivery

ACS Nano ◽  
2021 ◽  
Author(s):  
Franco Centurion ◽  
Abdul W. Basit ◽  
Jinyao Liu ◽  
Simon Gaisford ◽  
Md. Arifur Rahim ◽  
...  
Keyword(s):  
Probiotic Delivery

scholarly journals Probiotic Delivery through Non-Dairy Plant-Based Food Matrices

Agriculture ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 599
Author(s):  
D. M. D. Rasika ◽  
Janak K. Vidanarachchi ◽  
Selma F. Luiz ◽  
Denise Rosane Perdomo Azeredo ◽  
Adriano G. Cruz ◽  
...  
Keyword(s):  
Functional Properties ◽  
Dairy Products ◽  
Microbiological Quality ◽  
Health Benefit ◽  
Food Products ◽  
Quality Characteristics ◽  
Dairy Plant ◽  
Food Matrices ◽  
Probiotic Food ◽  
Probiotic Delivery

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. Traditionally, dairy products are the major and most popular probiotic carriers. At present, there is a growing demand for non-dairy probiotic products. Both fermented and non-fermented non-dairy plant-based food products are becoming highly appealing to both dairy and non-dairy consumers worldwide. Non-dairy plant-based food matrices such as fruits, vegetables, plant-based milk, cereals, and legumes have been used successfully in producing probiotic products with the minimum recommended viable probiotic numbers at the time of consumption. However, due to the exclusion of dairy, whether these food matrices can enhance the functional properties of probiotics such as gastrointestinal survival and immune-enhancing effects needs a thorough investigation. Hence, this review focuses on some of the popular non-dairy plant-based probiotic food products and their microbiological quality characteristics in terms of maintaining probiotic viability during product storage. Their gastrointestinal tolerance in these products, other functional properties, and product qualities have also been briefly discussed.

scholarly journals Applications, challenges, and needs for employing synthetic biology beyond the lab

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sierra M. Brooks ◽  
Hal S. Alper
Keyword(s):  
Synthetic Biology ◽  
Great Promise ◽  
Long Term Storage ◽  
Autonomous Function ◽  
Recent Advances ◽  
Resource Limited ◽  
Major Application ◽  
Further Development ◽  
Probiotic Delivery

AbstractSynthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.

scholarly journals Syringe-feeding as a novel delivery method for accurate individual dosing of probiotics in rats

2018 ◽  
Vol 9 (2) ◽  
pp. 311-315 ◽  
Author(s):  
S. Tillmann ◽  
G. Wegener
Keyword(s):  
Home Cage ◽  
Delivery Mode ◽  
Training Phase ◽  
Induce Stress ◽  
Delivery Method ◽  
Oral Gavage ◽  
Refinement Method ◽  
Dosing Accuracy ◽  
Probiotic Delivery

Probiotic administration to rodents is typically achieved using oral gavage or water bottles, but both approaches may compromise animal welfare, bacterial viability, dosing accuracy, or ease of administration. Oral gavage dosing may induce stress, especially when given daily over several weeks, and cannot be performed by inexperienced personnel. Delivery in water bottles does not take multiple co-housed animals into account, leading to inaccurate dosing of individual rats. Moreover, slow consumption of the solutions over several hours may lead to variability in bacterial stability, and potential leftovers or clogging of the bottle further threaten the reliability of this method. To date, no method has been described that can provide non-stressful precise dosing of probiotics or prebiotics in individual rats. In accordance with the 3R principles (replace, reduce, refine), we propose syringe-feeding as a refinement method for simple yet accurate administration of probiotics. Animals hereby voluntarily consume the solution directly from a syringe held into their home cage, thereby enabling controlled dosing of individual animals. This method requires a short training phase of approximately 3 days, but is very fast thereafter, only taking seconds per rat. Since studies using probiotics are usually long-term experiments, we consider syringe-feeding the most appropriate probiotic delivery mode available to date.

Development of a Probiotic Delivery System from Agrowastes, Soy Protein Isolate, and Microbial Transglutaminase

2011 ◽  
Vol 76 (3) ◽  
pp. H108-H115 ◽  
Author(s):  
Sok-Eng Yew ◽  
Ting-Jin Lim ◽  
Lee-Ching Lew ◽  
Rajeev Bhat ◽  
Azhar Mat-Easa ◽  
...  
Keyword(s):  
Delivery System ◽  
Soy Protein ◽  
Soy Protein Isolate ◽  
Protein Isolate ◽  
Microbial Transglutaminase ◽  
Probiotic Delivery

Harvesting the benefits of biofilms: A novel probiotic delivery system for the prevention of necrotizing enterocolitis

2016 ◽  
Vol 51 (6) ◽  
pp. 936-941 ◽  
Author(s):  
Jacob K. Olson ◽  
Terrence M. Rager ◽  
Jason B. Navarro ◽  
Lauren Mashburn-Warren ◽  
Steven D. Goodman ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Delivery System ◽  
Probiotic Delivery

scholarly journals Development and Evaluation of Probiotic Delivery Systems using the Rennet-induced Gelation of Milk Proteins

2021 ◽  
Author(s):  
Ho-Kyung Ha ◽  
Ji-Young Hong ◽  
Istifiani Lola Ayu ◽  
Mee-Ryung Lee ◽  
Won-Jae Lee
Keyword(s):  
Milk Proteins ◽  
Delivery Systems ◽  
Probiotic Delivery

scholarly journals Development of chitosan-coated agar-gelatin particles for probiotic delivery and targeted release in the gastrointestinal tract

2020 ◽  
Vol 104 (13) ◽  
pp. 5749-5757 ◽  
Author(s):  
Hanady A. Albadran ◽  
Andrea Monteagudo-Mera ◽  
Vitaliy V. Khutoryanskiy ◽  
Dimitris Charalampopoulos
Keyword(s):  
Gastrointestinal Tract ◽  
Targeted Release ◽  
Probiotic Delivery

scholarly journals Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Watcharaphong Chaemsawang ◽  
Weerapong Prasongchean ◽  
Konstantinos I. Papadopoulos ◽  
Suchada Sukrong ◽  
W. John Kao ◽  
...  
Keyword(s):  
Human Fibroblast ◽  
Potential Application ◽  
Mammalian Cells ◽  
Phase Inversion ◽  
Tween 80 ◽  
Cross Linking ◽  
Cell Delivery ◽  
Fibroblast Cells ◽  
Human Fibroblast Cells ◽  
Probiotic Delivery

Microencapsulation with biodegradable polymers has potential application in drug and cell delivery systems and is currently used in probiotic delivery. In the present study, microcapsules of human fibroblast cells (CRL2522) were prepared by emulsion cross-linking technique. Tween 80 surfactant at a 2% concentration through phase inversion resulted in the most efficient and stable size, morphology, and the cells survival at least 50% on day 14. Emulsion cross-linking microcapsule preparation resulted in smaller and possibly more diverse particles that can be developed clinically to deliver encapsulated mammalian cells for future disease treatments.

Perspectives on Existing and Novel Alternative Intravaginal Probiotic Delivery Methods in the Context of Bacterial Vaginosis Infection

2021 ◽  
Vol 23 (3) ◽  
Author(s):  
Priyadarshini Chandrashekhar ◽  
Farnaz Minooei ◽  
Wenndy Arreguin ◽  
Mohammadali Masigol ◽  
Jill M. Steinbach-Rankins
Keyword(s):  
Bacterial Vaginosis ◽  
Delivery Methods ◽  
Probiotic Delivery
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