A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy

ACS Nano ◽  
2021 ◽  
Author(s):  
Xiaoyu Huang ◽  
Wei Zhang ◽  
Yaowei Peng ◽  
Lu Gao ◽  
Fu Wang ◽  
...  
Keyword(s):  
Superoxide Radical ◽  
Tumor Therapy ◽  
Nickel Silicate ◽  
Hypoxic Tumor ◽  
Radical Generation

scholarly journals Characterization of membrane polypeptides from pea leaf peroxisomes involved in superoxide radical generation

1999 ◽  
Vol 337 (3) ◽  
pp. 531 ◽  
Author(s):  
Eduardo LÓPEZ-HUERTAS ◽  
Francisco J. CORPAS ◽  
Luisa M. SANDALIO ◽  
Luis A. DEL RÍO
Keyword(s):  
Superoxide Radical ◽  
Leaf Peroxisomes ◽  
Radical Generation

scholarly journals Analysis of Total Antioxidant Capacities of Various Seaweeds Grown off the Korean Coast (P06-110-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chai-Hyeon Lee ◽  
Ye-Na Park ◽  
Hyeung-Rak Kim ◽  
Sang Gil Lee ◽  
Bohkyung Kim
Keyword(s):  
Functional Food ◽  
Superoxide Radical ◽  
Radical Scavenging ◽  
Dpph Radical ◽  
Radical Scavenging Capacity ◽  
Antioxidant Capacities ◽  
Scavenging Capacity ◽  
Total Antioxidant ◽  
Radical Generation ◽  
Dpph Radical Scavenging

Abstract Objectives It has been a long time since seaweeds have been used for food ingredients in Asian countries. Recently, a body of research has revealed the health benefits of bioactive compounds in seaweeds, especially their antioxidant capacities. Although numerous seaweeds inhabit in the ocean, only a small percentage has been explored for functional food. Therefore, the purpose of this study was to analyze the antioxidant capacities of various seaweeds grown off the Korean coast to screen for the potential functional food sources. Methods Ten ethanol extracts of Korean seaweeds were provided by the National Marine Biodiversity Institute of Korea, which included Scytosiphon gracilis, Scytosiphon lomentaria, Sargassum muticum, Sargassum confusum, Petrospongium rugosum, Sargassum fusiforme, Petalonia fascia, Sargassum nigrifolium, Ishige foliacea, and Myelophycus simplex. Hundred mg/L of samples in 80% methanol was used to measure their ABTS, DPPH, and superoxide radical scavenging activities. Mg vitamin C equivalent antioxidant capacity (VCEAC)/100 mg was used to express the ABTS and DPPH radical scavenging capacities. For the superoxide radical scavenging capacity, inhibition rate of superoxide radical generation (%) was calculated. Results Among the ten seaweeds, S. nigrifolium and I. foliacea exhibited the most significant radical scavenging capacities. DPPH radical scavenging capacities of I. foliacea and S. nigrifolium were 122.4 mg VCEAC/100 mg and 95.8 mg VCEAC/100 mg, respectively. For ABTS radical scavenging capacity, I. foliacea exhibited 178.5 mg VCEAC/100 mg, followed by S. nigrifolium as 80.9 mg VCEAC/100 mg. I. foliacea inhibited about 68% of superoxide radical generation followed by S. nigrifolium (40.6%) while vitamin C as positive control inhibited about 28.9% of superoxide radical generation. The antioxidant capacities measured by the three assays were positively correlated with each other. Conclusions The current study explored total antioxidant capacities of various Korean seaweeds and found I. foliacea and S. nigrifolium as the most potential antioxidant-rich food resources. Further research would be warranted to investigate bioactive compounds from S. nigrifolium and I. foliacea. Funding Sources This work was supported by the Pukyong National University Research Fund in 2018.

scholarly journals Advances in nanomaterials for treatment of hypoxic tumor

2020 ◽  
Author(s):  
Mei-Zhen Zou ◽  
Wen-Long Liu ◽  
Han-Shi Chen ◽  
Xue-Feng Bai ◽  
Fan Gao ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
High Mortality ◽  
Therapeutic Efficacy ◽  
Tumor Invasion ◽  
Tumor Recurrence ◽  
Tumor Therapy ◽  
Functional Nanomaterials ◽  
Oxygen Levels ◽  
Hypoxic Conditions ◽  
Hypoxic Tumor

Abstract The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid proliferation of tumors, resulting from tumor invasion, progression and metastasis. The hypoxic conditions restrict efficiency of tumor therapies, such as chemotherapy, radiotherapy, phototherapy and immunotherapy, leading to serious results of tumor recurrence and high mortality. Recently, research has concentrated on developing functional nanomaterials to treat hypoxic tumors. In this review, we categorize such nanomaterials into (i) nanomaterials that elevate oxygen levels in tumors for enhanced oxygen-dependent tumor therapy and (ii) nanomaterials with diminished oxygen dependence for hypoxic tumor therapy. To elevate oxygen levels in tumors, oxygen-carrying nanomaterials, oxygen-generating nanomaterials and oxygen-economizing nanomaterials can be used. To diminish oxygen dependence of nanomaterials for hypoxic tumor therapy, therapeutic gas-generating nanomaterials and radical-generating nanomaterials can be used. The biocompatibility and therapeutic efficacy of these nanomaterials are discussed.

Adenosine inhibition of neutrophil damage during reperfusion does not involve KATP-channel activation

1997 ◽  
Vol 273 (4) ◽  
pp. H1677-H1687 ◽  
Author(s):  
Zhi-Qing Zhao ◽  
James C. Todd ◽  
Hiroki Sato ◽  
Xin-Liang Ma ◽  
J. Vinten-Johansen
Keyword(s):  
Infarct Size ◽  
Superoxide Radical ◽  
Receptor Activation ◽  
Polymorphonuclear Neutrophils ◽  
Vehicle Group ◽  
Myeloperoxidase Activity ◽  
Dependent Manner ◽  
Glucose Levels ◽  
Radical Generation ◽  
Dose Dependent

This study tests the hypothesis that cardioprotection exerted by adenosine A2-receptor activation and neutrophil-related events involves stimulation of ATP-sensitive potassium (KATP) channels on neutrophils during reperfusion. The adenosine A2 agonist CGS-21680 (CGS) inhibited superoxide radical generation from isolated rabbit polymorphonuclear neutrophils (PMNs) in a dose-dependent manner from 17.7 ± 2.1 to 7.4 ± 1.3 nmol/5 × 106 PMNs ( P < 0.05). Pinacidil, a KATP-channel opener, partially inhibited superoxide radical production, which was completely reversed by glibenclamide (Glib). Incremental doses of Glib in combination with CGS (1 μM) did not alter CGS-induced inhibition of superoxide radical generation. CGS significantly reduced PMN adherence to the endothelial surface of aortic segments in a dose-dependent manner from 189 ± 8 to 50 ± 6 PMNs/mm2( P < 0.05), which was also not altered by incremental doses of Glib. Infusion of CGS (0.025 mg/kg) before reperfusion reduced infarct size from 29 ± 2% in the Vehicle group to 15 ± 1% in rabbits undergoing 30 min of ischemia and 120 min of reperfusion ( P< 0.05). Glib (0.3 mg/kg) did not change the infarct size (28 ± 2%) vs. the Vehicle group and did not attenuate infarct size reduction by CGS (16 ± 1%). Glib did not change blood glucose levels. Cardiac myeloperoxidase activity was decreased in the ischemic tissue of the CGS group (0.15 ± 0.03 U/100 mg tissue) compared with the Vehicle group (0.37 ± 0.05 U/100 mg tissue; P < 0.05). We conclude that adenosine A2 activation before reperfusion partially reduces infarct size by inhibiting neutrophil activity and that this effect does not involve KATP-channel stimulation.

A Biocompatible Free Radical Nanogenerator with Real‐Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy

2019 ◽  
Vol 29 (39) ◽  
pp. 1903436 ◽  
Author(s):  
Yingpeng Wan ◽  
Guihong Lu ◽  
Jinfeng Zhang ◽  
Ziying Wang ◽  
Xiaozhen Li ◽  
...  
Keyword(s):  
Free Radical ◽  
Real Time ◽  
High Performance ◽  
Tumor Therapy ◽  
Real Time Monitoring ◽  
Hypoxic Tumor

Effect of Adriamycin on superoxide radical generation in isolated heart mitochondria

BIOPHYSICS ◽  
2007 ◽  
Vol 52 (6) ◽  
pp. 582-586 ◽  
Author(s):  
I. V. Sviryaeva ◽  
E. K. Ruuge ◽  
K. B. Shumaev
Keyword(s):  
Superoxide Radical ◽  
Isolated Heart ◽  
Heart Mitochondria ◽  
Radical Generation

Iron-induced changes in nitric oxide and superoxide radical generation in rat liver after lindane or thyroid hormone treatment

2001 ◽  
Vol 119 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Pamela Cornejo ◽  
Gladys Tapia ◽  
Susana Puntarulo ◽  
Mónica Galleano ◽  
Luis A. Videla ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Thyroid Hormone ◽  
Rat Liver ◽  
Superoxide Radical ◽  
Hormone Treatment ◽  
Radical Generation ◽  
Induced Changes

Mitochondrial respiratory activity and superoxide radical generation in the liver, brain and heart after chronic ethanol intake

1994 ◽  
Vol 47 (10) ◽  
pp. 1827-1833 ◽  
Author(s):  
Catherine Ribiere ◽  
Isabelle Hininger ◽  
Chantal Saffar-Boccara ◽  
Dominique Sabourault ◽  
Roger Nordmann
Keyword(s):  
Superoxide Radical ◽  
Respiratory Activity ◽  
Ethanol Intake ◽  
Chronic Ethanol ◽  
Radical Generation ◽  
Mitochondrial Respiratory Activity ◽  
Mitochondrial Respiratory
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