Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood–Brain Barrier

ACS Nano ◽  
2021 ◽  
Author(s):  
Badrul Alam Bony ◽  
Aria W. Tarudji ◽  
Hunter A. Miller ◽  
Saiprasad Gowrikumar ◽  
Sourav Roy ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Targeted Nanoparticles ◽  
Blood Brain

scholarly journals Modulating the Blood-Brain Barrier by Light Stimulation of Molecular-Targeted Nanoparticles

2020 ◽  
Author(s):  
Xiaoqing Li ◽  
Vamsidhara Vemireddy ◽  
Qi Cai ◽  
Hejian Xiong ◽  
Peiyuan Kang ◽  
...  
Keyword(s):  
Tight Junction ◽  
Tight Junctions ◽  
Blood Brain Barrier ◽  
Therapeutic Interventions ◽  
Brain Barrier ◽  
Light Stimulation ◽  
Targeted Nanoparticles ◽  
Blood Brain ◽  
The Brain ◽  
Stimulation Of

AbstractThe blood-brain barrier (BBB) tightly regulates the entry of molecules into the brain by tight junctions that seals the paracellular space and receptor-mediated transcytosis. It remains elusive to selectively modulate these mechanisms and to overcome BBB without significant neurotoxicity. Here we report that light stimulation of tight junction-targeted plasmonic nanoparticles selectively opens up the paracellular route to allow diffusion through the compromised tight junction and into the brain parenchyma. The BBB modulation does not impair vascular dynamics and associated neurovascular coupling, or cause significant neural injury. It further allows antibody and adeno-associated virus delivery into local brain regions. This novel method offers the first evidence of selectively modulating BBB tight junctions and opens new avenues for therapeutic interventions in the central nervous system.One Sentence SummaryGentle stimulation of molecular-targeted nanoparticles selectively opens up the paracellular pathway and allows macromolecules and gene therapy vectors into the brain.

Reversibly Modulating the Blood–Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles

Nano Letters ◽  
2021 ◽  
Author(s):  
Xiaoqing Li ◽  
Vamsidhara Vemireddy ◽  
Qi Cai ◽  
Hejian Xiong ◽  
Peiyuan Kang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Laser Stimulation ◽  
Targeted Nanoparticles ◽  
Blood Brain ◽  
Stimulation Of

scholarly journals A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 86
Author(s):  
Szilvia Veszelka ◽  
Mária Mészáros ◽  
Gergő Porkoláb ◽  
Anikó Szecskó ◽  
Nóra Kondor ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Cellular Uptake ◽  
Cationic Lipid ◽  
Specific Pattern ◽  
Brain Barrier ◽  
Brain Endothelial Cells ◽  
Targeted Nanoparticles ◽  
Blood Brain ◽  
Rat Brain Endothelial Cells

Nanosized drug delivery systems targeting transporters of the blood-brain barrier (BBB) are promising carriers to enhance the penetration of therapeutics into the brain. The expression of solute carriers (SLC) is high and shows a specific pattern at the BBB. Here we show that targeting ligands ascorbic acid, leucine and glutathione on nanoparticles elevated the uptake of albumin cargo in cultured primary rat brain endothelial cells. Moreover, we demonstrated the ability of the triple-targeted nanovesicles to deliver their cargo into midbrain organoids after crossing the BBB model. The cellular uptake was temperature- and energy-dependent based on metabolic inhibition. The process was decreased by filipin and cytochalasin D, indicating that the cellular uptake of nanoparticles was partially mediated by endocytosis. The uptake of the cargo encapsulated in triple-targeted nanoparticles increased after modification of the negative zeta potential of endothelial cells by treatment with a cationic lipid or after cleaving the glycocalyx with an enzyme. We revealed that targeted nanoparticles elevated plasma membrane fluidity, indicating the fusion of nanovesicles with endothelial cell membranes. Our data indicate that labeling nanoparticles with three different ligands of multiple transporters of brain endothelial cells can promote the transfer and delivery of molecules across the BBB.

Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer's disease

2005 ◽  
Vol 108 (2-3) ◽  
pp. 193-214 ◽  
Author(s):  
Celeste Roney ◽  
Padmakar Kulkarni ◽  
Veera Arora ◽  
Peter Antich ◽  
Frederick Bonte ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Targeted Nanoparticles ◽  
Blood Brain

scholarly journals Systemically Administered Brain-Targeted Nanoparticles Transport Peptides across the Blood—Brain Barrier and Provide Neuroprotection

2015 ◽  
Vol 35 (3) ◽  
pp. 469-475 ◽  
Author(s):  
Muge Yemisci ◽  
Secil Caban ◽  
Yasemin Gursoy-Ozdemir ◽  
Sevda Lule ◽  
Ramon Novoa-Carballal ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Infarct Volume ◽  
Drug Carriers ◽  
Artery Occlusion ◽  
Systemic Administration ◽  
Brain Barrier ◽  
Therapeutic Window ◽  
Targeted Nanoparticles ◽  
Blood Brain ◽  
The Brain

Although growth factors and anti-apoptotic peptides have been shown to be neuroprotective in stroke models, translation of these experimental findings to clinic is hampered by limited penetration of peptides to the brain. Here, we show that a large peptide like the basic fibroblast growth factor (bFGF) and a small peptide inhibitor of caspase-3 (z-DEVD-FMK) can effectively be transported to the brain after systemic administration by incorporating these peptides to brain-targeted nanoparticles (NPs). Chitosan NPs were loaded with peptides and then functionalized by conjugating with antibodies directed against the transferrin receptor-1 on brain endothelia to induce receptor-mediated transcytosis across the blood—brain barrier (BBB). Pre-ischemic systemic administration of bFGF- or z-DEVD-FMK-loaded NPs significantly decreased the infarct volume after 2-hour middle cerebral artery occlusion and 22-hour reperfusion in mice. Co-administration of bFGF- or z-DEVD-FMK-loaded NPs reduced the infarct volume further and provided a 3-hour therapeutic window. bFGF-loaded NPs were histologically detected in the brain parenchyma and also restored ischemia-induced Akt dephosphorylation. The neuroprotection was not observed when receptor-mediated transcytosis was inhibited with imatinib or when bFGF-loaded NPs were not conjugated with the targeting antibody, which enables them to cross the BBB. Nanoparticles targeted to brain are promising drug carriers to transport large as well as small BBB-impermeable therapeutics for neuroprotection against stroke.

scholarly journals Brain-targeted nanoparticles to overcome the blood-brain barrier

2020 ◽  
Vol 1 (1) ◽  
pp. 26-40
Author(s):  
Indrit SEKO ◽  
Adem ŞAHİN ◽  
Hayrettin TONBUL ◽  
Yılmaz ÇAPAN
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Targeted Nanoparticles ◽  
Blood Brain
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