Stem Cell-Derived Extracellular Vesicle-Bearing Dermal Filler Ameliorates the Dermis Microenvironment by Supporting CD301b-Expressing Macrophages

ACS Nano ◽  
2021 ◽  
Author(s):  
Dong Gil You ◽  
Jae Yoon An ◽  
Wooram Um ◽  
Jae Min Jung ◽  
Byeong Hoon Oh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Extracellular Vesicle ◽  
Dermal Filler

scholarly journals Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke Model

2019 ◽  
Vol 11 (4) ◽  
pp. 776-788 ◽  
Author(s):  
Samantha E. Spellicy ◽  
Erin E. Kaiser ◽  
Michael M. Bowler ◽  
Brian J. Jurgielewicz ◽  
Robin L. Webb ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ischemic Stroke ◽  
Functional Outcome ◽  
Neural Stem Cell ◽  
Functional Outcomes ◽  
Extracellular Vesicle ◽  
Stroke Model ◽  
Midline Shift ◽  
Post Stroke ◽  
Non Invasive

AbstractMagnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a stroke intervention is withheld or provided, in order to identify biomarkers for stroke functional outcome under these conditions. Fifteen MRI and ninety functional parameters were measured in a middle cerebral artery occlusion (MCAO) porcine ischemic stroke model. Multiparametric analysis of correlations between MRI measurements and functional outcome was conducted. Acute axial and coronal midline shift (MLS) at 24 h post-stroke were associated with decreased survival and recovery measured by modified Rankin scale (mRS) and were significantly correlated with 52 measured acute (day 1 post) and chronic (day 84 post) gait and behavior impairments in non-treated stroked animals. These results suggest that MLS may be an important non-invasive biomarker that can be used to predict patient outcomes and prognosis as well as guide therapeutic intervention and rehabilitation in non-treated animals and potentially human patients that do not receive interventional treatments. Neural stem cell–derived extracellular vesicle (NSC EV) was a disruptive therapy because NSC EV administration post-stroke disrupted MLS correlations observed in non-treated stroked animals. MLS was not associated with survival and functional outcomes in NSC EV–treated animals. In contrast to untreated animals, NSC EVs improved stroked animal outcomes regardless of MLS severity.

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke

2020 ◽  
Vol 62 ◽  
pp. 101106 ◽  
Author(s):  
Abolfazl Rahmani ◽  
Kiarash Saleki ◽  
Nima Javanmehr ◽  
Javad Khodaparast ◽  
Payam Saadat ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicle

scholarly journals Monocyte mimics improve mesenchymal stem cell-derived extracellular vesicle homing in a mouse MI/RI model

Biomaterials ◽  
2020 ◽  
Vol 255 ◽  
pp. 120168 ◽  
Author(s):  
Ning Zhang ◽  
Yanan Song ◽  
Zheyong Huang ◽  
Jing Chen ◽  
Haipeng Tan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicle

scholarly journals Functional equivalence of stem cell and stem cell‐derived extracellular vesicle transplantation to repair the irradiated brain

2019 ◽  
Vol 9 (1) ◽  
pp. 93-105 ◽  
Author(s):  
Sarah M. Smith ◽  
Erich Giedzinski ◽  
Maria C. Angulo ◽  
Tiffany Lui ◽  
Celine Lu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Extracellular Vesicle ◽  
Functional Equivalence

Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence

2021 ◽  
Author(s):  
Jiao Dong ◽  
Kiyoshi Sakai ◽  
Yoshiro Koma ◽  
Junna Watanabe ◽  
Kehong Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
Extracellular Vesicle ◽  
Dental Pulp Stem Cell
Sign in / Sign up

Export Citation Format

Share Document