Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis

ACS Nano ◽  
2021 ◽  
Author(s):  
Sean K Bedingfield ◽  
Juan M. Colazo ◽  
Martina Di Francesco ◽  
Fang Yu ◽  
Danielle D. Liu ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Top Down ◽  
Matrix Metalloproteinase 13 ◽  
Post Traumatic

scholarly journals Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yusheng Li ◽  
Wei Jiang ◽  
Hua Wang ◽  
Zhenhan Deng ◽  
Chao Zeng ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 13

Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF-κB pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF-κB pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF-κB pathway.

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